Pathogenetic rationale for the use of skin care products in patients suffering from atopic dermatitis
- Authors: Dvoryankova Y.V1
-
Affiliations:
- Center of Theoretic Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences
- Issue: Vol 89, No 1 (2013)
- Pages: 63-65
- Section: Articles
- URL: https://journals.rcsi.science/0042-4609/article/view/117080
- DOI: https://doi.org/10.25208/vdv611
- ID: 117080
Cite item
Full Text
Abstract
Filaggrin is a key protein participating in the differentiation of epidermal cells, which prevents any excessive transepidermal water loss and contributes to the maintenance of skin barrier properties. Mutations in the filaggrin gene (FLG) are among the most important factors predisposing to the development of atopy. Today correct skin care comprising the use of moisturizing and softening products forms an integral part of the therapy for patients with atopic dermatitis and an important component of measures aimed at the reduction of the number of exacerbations and extension of the remission.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Ye V Dvoryankova
Center of Theoretic Problems of Physical and Chemical Pharmacology, Russian Academy of Sciences
Email: dvoriankova@mail.ru
д.м.н., ведущий научный сотрудник Центра теоретических проблем физико-химической фармакологии РАН Москва
References
- Steinert P.M., Cantieri J.S., Teller D.C. et al. Characterization of a class of cationic proteins that specifically interact with intermediate filaments. Proc Natl Acad Sci USA 1981; 4097—4101.
- Sandilands A., Sutherland C., Irvine A.D. et al. Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci 2009; 122(9): 1285—1294.
- Саликова Т.И., Максимов В.Н., Максимова Ю.В. и др. Мутации в гене филаггрина как предрасполагающий фактор развития атопического дерматита. Клин. дерматол. и венерол. 2010; 3: 4—7.
- Cookson W.O., Ubhi B., Lawrence R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 2001; 27(4): 372—3.
- Carlsen B.C., Thyssen J.P., Menné T. et al. Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy. Clin Exp Dermatol 2011; 36: 467—72.
- Brown S.J., Kroboth K., Sandilands A. et al. Intragenic copy number variation within Filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol 2012; 132: 98—104.
- Lim S.W., Hong S.P., Jeong S.W. et al. Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator activated receptor-alpha. J Dermatol 2007; 34: 625—34.
- Аравийская Е.Р., Соколовский Е.В. Сухость кожи. Причины и механизмы возникновения. Принципы коррекции. Журн. дерматовенерол. и косметол. 2002; 2: 10—14
Supplementary files
