A STUDY OF THE ROLE PLAYED BY THE POLYMORPHISM OF GENES ENCODING CYTOKINES IN THE DEVELOPMENT OF COMPLICATIONS OF THE UROGENITAL CHLAMYDIA INFECTION IN WOMEN
- Authors: Plakhova KI1
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Affiliations:
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Issue: Vol 89, No 4 (2013)
- Pages: 44-51
- Section: Articles
- URL: https://journals.rcsi.science/0042-4609/article/view/117064
- DOI: https://doi.org/10.25208/vdv607
- ID: 117064
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Abstract
The author describes the results of a study of the polymorphism of genes encoding cytokines IL-6, IL-10, TnF-α, IFN-γ, TGF-β 1 and MBL2 in women suffering from the urogenital chlamydia infection (40 subjects), women with secondary infertility caused by the Chlamydia infection in the medical history (20 subjects) and clinically healthy women of childbearing potential (control group, 20 subjects). The SnapShot multiplex molecular and genetic method was used to study the polymorphism of genes. As a result of the study, the most frequent genotypes were revealed for each polymorphism of cytokine genes. reliable associations (0.01 < р < 0.001) were established between the frequency of individual genotypes (IL6*-174C/C, IL-10*-1082G/A, TGF-β 1*-915G/C, TGF-β 1*-869T/C and MBL2*-204G/G) and the onset of complications of the urogenital chlamydia infection, which makes it possible to exam ine these variants of genotypes as markers of an increased risk for the complicated course of the urogenital chlamydia infection resulting in reproductive disorders in women.
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##article.viewOnOriginalSite##About the authors
K I Plakhova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Email: plahova_xenia@mail.ru
к.м.н., старший научный сотрудник отдела инфекций, передаваемых половым путем 107076, москва, ул. Короленко, д. 3, стр. 6
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