The dynamics of some human skin biophysical parameters in the process of optical clearing after hyperosmotic solutions topical application
- Authors: Utz S.R.1, Tuchin V.V.2, Galkina E.M.1
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Affiliations:
- Saratov State Medical University named after V.I. Rasumosky
- Saratov State University named after N.G. Chernyshevsky
- Issue: Vol 91, No 4 (2015)
- Pages: 60-68
- Section: ORIGINAL STUDIES
- URL: https://journals.rcsi.science/0042-4609/article/view/116688
- DOI: https://doi.org/10.25208/0042-4609-2015-91-4-60-68
- ID: 116688
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Full Text
Abstract
Goal of the study. To study changes of certain biophysical parameters of human skin in the process of optical (immersion) clarification under the effect of hyperosmotic agents. Materials and methods. Measurements were made on the skin (on the right and left hands) of 18 female volunteers aged 17-38. Biophysical parameters of the skin and its phototype were determined with the use of Soft Plus, a device for the diagnostics of the skin condition (Callegari, Italy), and erythema melanin meter (EMM-002E, Russia). 30%, 40% and 50% aqueous glucose solutions as well as 50% aqueous-alcoholic (30°) fructose solution were used as hyperosmotic (dehydrating) study agents. Results. It was revealed that the extent and time of skin dehydration mostly depend on the method of application of the immersion agent and its composition. Depending on the applied technology, it is possible to achieve both a decrease and an increase in the skin moisture extent, which is related to the physiological response of the skin to the occlusion and osmotic action of the agents. 50% aqueous-alcoholic fructose solution appears to be the most efficient dehydrating agent of all study agents.
About the authors
S. R. Utz
Saratov State Medical University named after V.I. Rasumosky
Author for correspondence.
Email: s_utz@mail.ru
Russian Federation
V. V. Tuchin
Saratov State University named after N.G. Chernyshevsky
Email: noemail@neicon.ru
Russian Federation
E. M. Galkina
Saratov State Medical University named after V.I. Rasumosky
Email: noemail@neicon.ru
Russian Federation
References
- Rezaykin A.V., Kubanova A.A., Rezaykina A.V. Non-invasive methods of the human skin investigation. Vestnik dermatologii i venerologii 2009; (6): 28-32.
- Shtirshnayder Yu.Yu., Michenko A.V., Katunina O.R., Zubarev A.R. New non-invasive imaging technology in dermatology. Vestnik dermatologii i venerologii 2011; (5): 41-53.
- Sinichkin Yu.P., Utz S.R. In vivo reflectance and fluorescence spectroscopy of the human skin. Saratov: Izd-vo SGU; 2001.
- Sinichkin Yu.P., Kollias N., Utz S.R. et al. Reflectance and fluorescence spectroscopy of the human skin in vivo. V: Opticheskaya biomeditsinskaya diagnostika: v 2 t. Pod red. V.V. Tuchina. Moskva: Fizmatlit 2007; 1: 77-124.
- Utz S.R. Optics of the human skin. V: Nizkointensivnaya lazernaya terapiya. Pod red. Moskvina S.V., Buylina V.A. M: TOO «Firma «Tehnika», 2000. 58-70.
- Gratton E. Deeper tissue imaging with total detection. Science 2011; 331: 1016-1017.
- Liew Y., McLaughlin R., Wood F., Sampson D. Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo. Journal of Biomedical Optics 2011; 16 (11): 116018.
- Tuchin V.V. A clear vision for laser diagnostics (review). IEEE Journal Quantum Electronics 2007; 13: 1621-1628.
- Tuchin V.V. Optical Clearing of Tissues and Blood., Bellingham: SPIE Press: 2006.
- Agrba P., Kirillin M., Abelevich A. et al. Compression as a method for increasing the informativity of optical coherence tomography of biotissue. Optics and Spectroscopy 2009; 107 (6): 853-858.
- Guzelsu N., Federici J., Lim H. et al. Measurement of skin strech via light reflection. Journal of Biomedical Optics 2003; 8: 80-86.
- Yu T., Wen X., Tuchin V. et al. Quantitative analysis of dehydration in porcine skin for assessing mechanism of optical clearing. Journal of Biomedical Optics 2011; 16: 095002.
- Lin W.-C., Motamedi M., Welch A. Dynamics of tissue optics during laser heating of turbid media. Applied Optics 1996; 35 (19): 3413-3420.
- Genina E.A., Bashkatov A.N., Sinichkin Yu.P. et al. Optical ckearing of biological tissues: prospects of application in medical diagnostics and phototherapy. Journal of Biomedical Photonics and Engineering 2015; 1 (1): 22-58.
- Doubrovskii V.A., Yanina I.Yu., Tuchin V.V. Kinetics of changes in the coefficient of transmission of the adipose tissue in vitro as a result of photodynamic action. Biophysics 2012; 57 (1): 94-98.
- Yanina I.Yu., Trunina N.A., Tuchin V.V. Optical coherence tomography of adipose tissue at photodynamic/photothermal treatment in vitro. Journal Innovation Optical Health Science 2013; 6(2): 1350010.
- Zhu D., Larin K.V., Luo Q., Tuchin V.V. Recent progress in tissue optical clearing. Laser Photonics Review 2013; 7 (5): 732-757.
- Handbook of non-invasive methods and the skin / ed. By J. Serup et al. - 2nd ed., CRC; 2006.
- Tagami H. Electrical measurement of the hydration state of the skin surface in vivo // British Journal of Dermatology 2014; 171: 29-33.
- Dolotov L.E., Sinichkin Yu.P., Utz S.R. et al. Design and evaluation of a novel portable erythema-melanin-meter. Lasers in Surgery and Medicine 2004; 34 (2): 127-135.
- Loden M. Interaction between the stratum corneum and topically applied products: regulatory, instrumental and formulations issues with focus on moisturizers. British Journal of Dermatology 2014; 171: 38-44.
- Sato J., Yanai M., Hirao N., Denda M. Water content and thickness of the stratum corneum contribute to skin surface morphology. Arch. Dermatology Research 2000; 292: 412-417.
- Verdier-Sevrain S., Bonte F. Skin hydration: a review on its molecular mechanisms. Journal Cosmet. Dermatology 2007; 6: 75-82.
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