A study of the level of circulating cytokines in patients with atopic dermatitis
- Authors: Volkova Y.N.1, Morozov S.G.2, Tarasova M.V.1, Grigoriyeva A.A.3, Yelistratova I.V.4
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Affiliations:
- The Russian National Research Medical University named after N.I. Pirogov
- Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Central Military Clinical Hospital Russian Interior Troops
- Issue: Vol 90, No 2 (2014)
- Pages: 26-30
- Section: ORIGINAL STUDIES
- URL: https://journals.rcsi.science/0042-4609/article/view/116582
- DOI: https://doi.org/10.25208/0042-4609-2014-90-2-26-30
- ID: 116582
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Abstract
Goal of the study. To study the role of pro-inflammatory and anti-inflammatory cytokines for the course of atopic dermatitis (AD). Materials and methods. The study involved 72 patients aged 25-55 suffering from atopic dermatitis for 2-30 years and with at least two relapses a year. The AD patients were assigned to the following groups depending on the SCORAD (iSc) index: Group 1: light form (iSc < 30 points), Group 2: moderate to severe form (iSc from 30 to 50 points) and Group 3: severe form (iSc > 50 points). The control group comprised 23 practically healthy subjects aged 25-35. The level of cytokines (IL-1 β, -4, -6, -8, -10, -12, -13, TNF-α and IFN-γ) in blood serum was determined based on the immune-enzyme assay method. Results. A trend to the increased production of anti-inflammatory cytokines (IL-4, -6, -10, -13) at the exacerbation stage and increased synthesis of pro-inflammatory ones (IFN-γ, TNF-α and IL-12) at the remission stage was observed in patients with atopic dermatitis, which confirms the dysregulation of reciprocal relationships between Th1 and Th2 lymphocyte subpopulations during the disease.
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About the authors
YE. N. Volkova
The Russian National Research Medical University named after N.I. Pirogov
Author for correspondence.
Email: volkovaen@cnikvi.ru
Russian Federation
S. G. Morozov
Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences
Email: noemail@neicon.ru
Russian Federation
M. V. Tarasova
The Russian National Research Medical University named after N.I. Pirogov
Email: noemail@neicon.ru
Russian Federation
A. A. Grigoriyeva
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
Email: noemail@neicon.ru
Russian Federation
I. V. Yelistratova
Central Military Clinical Hospital Russian Interior Troops
Email: noemail@neicon.ru
Russian Federation
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