Level of the proliferative activity of lymphocytes in case of mycosis fungoides and plaque parapsoriasis
- 作者: Zhukov A.S.1, Belousova I.E.1, Khairutdinov V.R.1, Telichko I.N.1, Samtsov A.V.1
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隶属关系:
- Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
- 期: 卷 90, 编号 1 (2014)
- 页面: 30-36
- 栏目: ORIGINAL STUDIES
- URL: https://journals.rcsi.science/0042-4609/article/view/116571
- DOI: https://doi.org/10.25208/0042-4609-2014-90-1-30-36
- ID: 116571
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全文:
详细
The level of the proliferative activity is an important predictor of a number of oncologic diseases; at the same time, its diagnostic value for mycosis fungoides was not adequately investigated. Goal. To study the proliferative activity of lymphocytes in the skin of patients suffering form mycosis fungoides and plaque parapsoriasis. Materials and methods. The level of CD3+ and Ki-67+ cells was determined in skin biopsy samples taken from patients suffering from mycosis fungoides (18 subjects) and plaque parapsoriasis (6 subjects) by means of immunohistochemistry. The epidermal to dermal skin cell proliferative activity ratio (Ki-67+) and cell proliferative activity index were calculated. The control group comprised 16 healthy people. Results. The epidermal to dermal skin cell proliferative activity ratio amounted to 10.9 in healthy people, 5.43 in patients suffering from plaque parapsoriasis, and 3.84 and 2.42 in patients suffering from mycosis fungoides, spotty and plaque and tumor stages, respectively. The percentage of proliferative CD3+Ki-67+ cells relative to the total number of T-lymphocytes amounted to 1% in the patients suffering from plaque parapsoriasis and 3% in the patients with mycosis fungoides, spotty stage. Conclusion. The epidermal to dermal skin cell proliferative activity ratio (Ki-67+) in patients suffering from mycosis fungoides at any stage is lower than that in healthy subjects and patients suffering from parapsoriasis. The cell proliferative activity index was higher in the patients with mycosis fungoides, plaque and tumor stage, than in the patients with parapsoriasis. The number of CD3+Ki-67+ cells was higher in the patients with mycosis fungoides, spotty and plaque and tumor stages, than in the healthy subjects and patients suffering from parapsoriasis.
作者简介
A. Zhukov
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
编辑信件的主要联系方式.
Email: md.zhukov@gmail.com
俄罗斯联邦
I. Belousova
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
Email: noemail@neicon.ru
俄罗斯联邦
V. Khairutdinov
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
Email: noemail@neicon.ru
俄罗斯联邦
I. Telichko
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
Email: noemail@neicon.ru
俄罗斯联邦
A. Samtsov
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation Akademika
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Лез-винская Е.М., Молочков В.А., Ларина Н.К. Состояние заболеваемости злокачественными лимфомами кожи в Московской области и пути совершенствования лечебно-диагностической помощи больным. Росс. журн. кож. и вен. бол. 2000; (4): 12-17.
- Ackerman A.B. If small plaque (digitate) parapsoriasis is a cutaneous T-cell lymphoma, even an «abortive» one, it must be mycosis fungoides! Arch Dermatol 1996; 132: 562-566.
- Willemze R., Jaffe E.S., Burg G. et al. WHOEORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-3785.
- Бабиченко И.И., Ковязин В.А. Новые методы иммуногистохимической диагностики опухолевого роста: Учеб. пособие. М: РУДН, 2008; 109.
- Golmohammadi R., Pejhan A. The prognostic value of the P53 protein and the Ki-67 marker in breast cancer patients. J Pak Med Assoc 2012; 62 (9): 871-875.
- Foltyn W., Zajеçki W., Marek B. et al. The value of the Ki-67 proliferation marker as a prognostic factor in gastroenteropancreatic neuroendocrine tumours. Endokrynol Pol 2012; 63 (5): 362-366.
- He W.L., Li Y.H., Yang D.J. et al. Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma. Eur J Surg Oncol. 2013; 39 (2): 141-149.
- Jovanovich M.P., Jakovich L., Bogdanovich A. et al. Poor outcome in patients with diffuse large B-cell lymphoma is associated with high percentage of bcl-2 and Ki 67-positive tumor cells. Vojnosanit Pregl 2009; 66 (9): 738-743.
- Dummer R., Michie S.A., Kell D. et al. Expression of bcl-2 protein and Ki-67 nuclear proliferation antigen in benign and malignant cutaneous T-cell infiltrates. J Cutan Pathol 1995; 22 (1): 11-17.
- Gambichler T., Bischoff S., Bechara F.G. et al. Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders. J Dermatol Sci 2008; 49 (2): 125-132.
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