Особенности структуры и функций бактериальных комплексов SMC

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Аннотация

Белковые комплексы SMC (от англ. Structural maintenance of chromosomes, далее в тексте – комплексы SMC) являются ключевыми участниками пространственной организации ДНК во всех живых организмах – в бактериях, археях и эукариотах. У бактерий имеется несколько гомологов комплексов SMC, которые выполняют, на первый взгляд, несвязанные друг с другом функции, однако действуют посредством очень похожих между собой, высококонсервативных механизмов. За последние годы установлено, что комплексы SMC способны осуществлять формирование петель ДНК (посредством так называемой экструзии петель), что позволяет рассматривать их как отдельный класс ДНК-транслоказ. В данной работе обсуждаются бактериальные комплексы SMC в сравнении с их гомологами, такими как MukBEF, MksBEF, RecN и Wadjet, а также с комплексами SMC эукариот. Обсуждаются их свойства, роль и функции в ключевых процессах бактериальной клетки.

Об авторах

Н. Е. Морозова

Научно-исследовательский комплекс “Нанобиотехнологии” Санкт-Петербургского политехнического университета Петра Великого

Email: misterkotlin@gmail.com
Россия, 195251, Санкт-Петербург

А. С. Потысьева

Научно-исследовательский комплекс “Нанобиотехнологии” Санкт-Петербургского политехнического университета Петра Великого

Email: misterkotlin@gmail.com
Россия, 195251, Санкт-Петербург

А. Д. Ведяйкин

Научно-исследовательский комплекс “Нанобиотехнологии” Санкт-Петербургского политехнического университета Петра Великого

Автор, ответственный за переписку.
Email: misterkotlin@gmail.com
Россия, 195251, Санкт-Петербург

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