Respiratory diseases and obesity: special phenotype or independent events: Review
- 作者: Shchepikhin E.1, Shmelev E.1, Zaytseva A.1
-
隶属关系:
- Central Tuberculosis Research Institute
- 期: 卷 94, 编号 3 (2022)
- 页面: 442-447
- 栏目: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/90386
- DOI: https://doi.org/10.26442/00403660.2022.03.201412
- ID: 90386
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A combination of factors, including Western European eating habits, physical inactivity and genetic predisposition, lead to a dramatic increase in adipose tissue mass. A special place is occupied by abdominal obesity, in which there is an accumulation of adipose tissue in the mesentery of the small intestine and the omentum. Developing in conditions of visceral obesity, insulin resistance, dyslipidemia and systemic inflammation are one of the key components of the pathogenesis of type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fatty liver and pancreas disease, polycystic ovary disease, some forms of cancer (breast cancer, endometrial cancer, colonic and direct intestines). At the same time, the pathogenetic role of adipose tissue is not limited to its participation in the formation of the cardiometabolic continuum and oncogenesis. The most important role of metabolically active fat in the pathogenesis of many respiratory diseases is known, including bronchial asthma, obstructive sleep apnea and pulmonary hypertension. This paper presents an overview of current data on immunological, pathophysiological and clinical features of the phenotype of the combination of respiratory diseases with overweight and obesity.
作者简介
Evgeniy Shchepikhin
Central Tuberculosis Research Institute
编辑信件的主要联系方式.
Email: shhepikhin11@yandex.ru
ORCID iD: 0000-0002-9146-0904
аспирант отд. дифференциальной диагностики туберкулеза легких и экстракорпоральных методов лечения
俄罗斯联邦, MoscowEvgene Shmelev
Central Tuberculosis Research Institute
Email: shhepikhin11@yandex.ru
ORCID iD: 0000-0002-1908-5601
д-р мед. наук, проф., гл. науч. сотр. отд. дифференциальной диагностики туберкулеза легких и экстракорпоральных методов лечения
俄罗斯联邦, MoscowAnna Zaytseva
Central Tuberculosis Research Institute
Email: shhepikhin11@yandex.ru
ORCID iD: 0000-0001-7155-5730
канд. мед. наук, ст. науч. сотр. отд. дифференциальной диагностики туберкулеза легких и экстракорпоральных методов лечения
俄罗斯联邦, Moscow参考
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