Metabolic, inflammatory and imaging biomarkers in evaluation of coronary atherosclerosis severity in patients with coronary artery disease and diabetes mellitus type 2
- 作者: Koshelskaya O.1, Kharitonova O.1, Kologrivova I.1, Suslova T.1, Margolis N.1, Tereshenkova E.1, Rybina A.1, Karpov R.1
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隶属关系:
- Tomsk National Research Center for Medicine
- 期: 卷 93, 编号 9 (2021)
- 页面: 1030-1036
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/82964
- DOI: https://doi.org/10.26442/00403660.2021.09.201032
- ID: 82964
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Aim. To study interconnections between epicardial adipose tissue thickness (EATt), parameters of glucose metabolism/insulin, C-reactive protein (hsCRP), serum adipokines and severity of coronary artery disease (CAD) depending on the presence of diabetes mellitus type 2 (DM 2); to determine significant markers of CAD severity in patients with DM 2.
Materials and methods. The study involved 106 patients with CAD (m/f – 64/42, 60.9±6.8 years), including patients with DM 2 (group 1, n=35) and non-diabetic patients (group 2, n=71). Severity of CAD was evaluated according to angiography data with calculation of Gensini Score (GS). EATt was assessed via echocardiography. Serum levels of glucose/insulin metabolism parameters, lipid fractions, hsCRP and adipokines were evaluated. Clinical parameters, including GS, did not differ between groups.
Results. EAT thickness median was elevated in gr.1 (5.1 mm vs. 4.4 mm in group 2), while adiponectin levels were decreased (6.55 µg/ml vs. 7.71 µg/ml). Linear regression of body mass index and resistin levels on EATt was revealed in gr.1; in gr.2 EATt linearly increased with waist circumference increment when EATt<6 mm. Linear regression of EATt on GS was revealed in gr.1 when EATt<8 mm, while linear regression in the whole GS range was obtained for HDL-C and hsCRP levels.
Conclusion. Study results demonstrate differences in mechanisms of deposition and functioning of epicardial and abdominal adipose tissue depending on the presence or absence of diabetic status. Patients with DM2 are characterized by the excessive EAT deposition and decrease of serum adiponectin levels compared to non-diabetic patients in the equal conditions. Independent markers of CAD severity in DM 2 are decreased HDL-C and increased hsCRP levels, but not EATt.
作者简介
Olga Koshelskaya
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0002-6679-1269
д-р мед. наук, проф., вед. науч. сотр. отд. атеросклероза и хронической ишемической болезни сердца НИИ кардиологии
俄罗斯联邦, TomskOlga Kharitonova
Tomsk National Research Center for Medicine
编辑信件的主要联系方式.
Email: koshel@live.ru
ORCID iD: 0000-0002-2818-5882
мл. науч. сотр. отд. атеросклероза и хронической ишемической болезни НИИ кардиологии
俄罗斯联邦, TomskIrina Kologrivova
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0003-4537-0008
канд. мед. наук, науч. сотр. отд. функциональной и лабораторной диагностики НИИ кардиологии
俄罗斯联邦, TomskTatiana Suslova
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0001-9645-6720
канд. мед. наук, вед. науч. сотр. отд. функциональной и лабораторной диагностики НИИ кардиологии
俄罗斯联邦, TomskNatalia Margolis
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0001-8890-9814
канд. техн. наук отд. функциональной и лабораторной диагностики НИИ кардиологии
俄罗斯联邦, TomskEkaterina Tereshenkova
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0002-2613-7852
канд. мед. наук, мл. науч. сотр. отд. атеросклероза и хронической ишемической болезни сердца НИИ кардиологии
俄罗斯联邦, TomskAnastasiia Rybina
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0002-6488-0647
канд. мед. наук, мл. науч. сотр. отд. рентгеновских и томографических методов диагностики НИИ кардиологии
俄罗斯联邦, TomskRostislav Karpov
Tomsk National Research Center for Medicine
Email: koshel@live.ru
ORCID iD: 0000-0002-7011-4316
акад. РАН, д-р мед. наук, проф., науч. рук. НИИ кардиологии
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