Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic
- 作者: Ianushevich O.1, Maev I.1, Krikheli N.1, Levchenko O.1, Rogova I.1, Zaborovskii A.1, Andreev D.1, Kebina A.1, Bordin D.1,2, Bakulin I.3, Bakulina N.3, Andreev N.1, Asadulin P.1, Bagdasarian A.1, Devkota M.1, Evarnitskaia N.1, Krikunova O.1, Kucher S.1, Sokolov F.1, Fomenko A.1, Khar'kovskii V.1, Sharina I.1
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隶属关系:
- Yevdokimov Moscow State University of Medicine and Dentistry
- Tver State Medical University
- Mechnikov North-Western State Medical University
- 期: 卷 93, 编号 8 (2021)
- 页面: 853-861
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/79412
- DOI: https://doi.org/10.26442/00403660.2021.08.200977
- ID: 79412
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Aim. Assessment of the prevalence and prognostic value of gastroenterological manifestations in patients with COVID-19.
Materials and methods. A single-center retrospective cohort study was carried out. Only cases with laboratory confirmed detection of SARS-CoV-2 virus RNA using polymerase chain reaction in oro-/nasopharyngeal smear samples were subject to analysis. Patients with documented (according to anamnestic data and/or according to examination data during hospitalization) organic pathology of the gastrointestinal tract (GIT) and/or hepatobiliary system, malignant neoplasms of any localization, as well as pregnant patients were excluded from the general register of retrospective data. The final cohort was divided into two groups depending on the presence of gastrointestinal symptoms: COVID-19 with gastrointestinal symptoms (cases) and COVID-19 without gastrointestinal symptoms (control).
Results. The final sample consisted of 3764 patients, including 2108 (56%) women and 1656 (44%) men. The average age of the subjects included in the analysis was 58.0 years (95% confidence interval – CI 48.6–63.0). In the study cohort, gastroenterological manifestations (alone or in combination) were recorded in 885 (23.51%) patients. Calculation of the odds ratio (OR) of unfavorable and lethal outcomes between the analyzed groups showed that the presence of gastroenterological symptoms significantly increases the chances of lethal outcome in a cohort of elderly and senile patients (OR 1.6817, 95% CI 1.0335–2.7364; p=0.0364), determines a higher risk of hospitalization or transfer to the intensive care unit (OR 1.2959, 95% CI 1.0547–1.5922; p=0.0136), development of acute respiratory distress syndrome (OR 1.5952, 95% CI 1.3164–1.9329; p<0.0001), as well as the need for mechanical ventilation (OR 1.2849, 95% CI 1.077–1.5329; p=0.0054).
Conclusion. The present study has demonstrated that gastroenterological symptoms are detected in about one in four patients infected with the SARS-CoV-2 virus and multiply the risk of adverse and life-threatening complications of COVID-19.
作者简介
Oleg Ianushevich
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-4293-8465
академик РАН, доктор медицинских наук, профессор, ректор, заведующий кафедрой пародонтологии
俄罗斯联邦, MoscowIgor Maev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-6114-564X
академик РАН, доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии
俄罗斯联邦, MoscowNatella Krikheli
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
доктор медицинских наук, профессор, заведующий кафедрой клинической стоматологии
俄罗斯联邦, MoscowOleg Levchenko
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-0857-9398
доктор медицинских наук, профессор кафедры нейрохирургии и нейрореанимации
俄罗斯联邦, MoscowIrina Rogova
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-5868-8870
начальник управления науки, завед. лабораторией микробиологического анализа Клинического центра COVID-19
俄罗斯联邦, MoscowAndrei Zaborovskii
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-7923-9916
доктор медицинских наук, доцент, заведующий кафедрой фармакологии
俄罗斯联邦, MoscowDmitrii Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-4007-7112
кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии
俄罗斯联邦, MoscowAnastasiia Kebina
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-7570-9650
ассистент кафедры терапии, клинической фармакологии и скорой медицинской помощи
俄罗斯联邦, MoscowDmitrii Bordin
Yevdokimov Moscow State University of Medicine and Dentistry; Tver State Medical University
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-2815-3992
доктор медицинских наук, профессор каф. пропедевтики внутренних болезней и гастроэнтерологии ФГБОУ ВО «МГМСУ им. А.И. Евдокимова», зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта ГБУЗ «МКНЦ им. А.С. Логинова», профессор кафедры поликлинической терапии и семейной медицины ФГБОУ ВО ТГМУ
俄罗斯联邦, Moscow;TverIgor Bakulin
Mechnikov North-Western State Medical University
Email: dna-mit8@mail.ru
доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и диетологии
俄罗斯联邦, Saint PetersburgNatalia Bakulina
Mechnikov North-Western State Medical University
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-4075-4096
доктор медицинских наук, профессор каф. терапии и клинической фармакологии
俄罗斯联邦, Saint PetersburgNikolai Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-5136-0140
кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии
俄罗斯联邦, MoscowPavel Asadulin
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-5236-1770
врач-специалист отд-ния микробиологического анализа Клинического центра COVID-19
俄罗斯联邦, MoscowArmine Bagdasarian
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-0528-2903
врач-специалист Клинического центра COVID-19
俄罗斯联邦, MoscowMikhail Devkota
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-3736-4196
врач-специалист отделения микробиологического анализа Клинического центра COVID-19, преподаватель кафедры фармакологии
俄罗斯联邦, MoscowNatalia Evarnitskaia
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-6250-1714
врач-специалист отд-ния микробиологического анализа Клинического центра COVID-19, ст. лаборант кафедры пародонтологии
俄罗斯联邦, MoscowOlga Krikunova
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-6836-1425
врач-специалист отд-ния микробиологического анализа Клинического центра COVID-19, зав. учебной частью каф. клинической функциональной диагностики МГМСУ
俄罗斯联邦, MoscowSergei Kucher
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-7981-1786
врач-специалист отделения микробиологического анализа Клинического центра COVID-19
俄罗斯联邦, MoscowFilip Sokolov
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-2813-6498
врач-специалист отделения микробиологического анализа Клинического центра COVID-19, старший лаборант кафедры ЮНЕСКО «Здоровый образ жизни – залог успешного развития»
俄罗斯联邦, MoscowAleksei Fomenko
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-1794-7263
врач-специалист отделения микробиологического анализа Клинического центра COVID-19, преподаватель кафедры фармакологии МГМСУ
俄罗斯联邦, MoscowVadim Khar'kovskii
Yevdokimov Moscow State University of Medicine and Dentistry
Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-8659-3502
врач-специалист отделения микробиологического анализа Клинического центра COVID-19
俄罗斯联邦, MoscowIrina Sharina
Yevdokimov Moscow State University of Medicine and Dentistry
编辑信件的主要联系方式.
Email: dna-mit8@mail.ru
ORCID iD: 0000-0003-0347-0123
врач-специалист Клинического центра COVID-19
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