Experience of olokizumab use in COVID-19 patients

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Most subjects with the COVID-19 experience mild to moderate symptoms, but approximately 10% of cases suffer from severe course of disease. IL-6 inhibitors are actively used to neutralize and prevent the «cytokine storm». Olokizumab is a humanized monoclonal antibody belonging to the G4/Kappa immunoglobulin isotype that selectively binds to human IL-6 and effectively neutralizes it.

Aim. To evaluate the efficacy and safety of Artlegia (olokizumab) for the treatment of subjects with a disease caused by the SARS-COV-2 virus in a real-world clinical setting.

Materials and methods. The analysis included data of 610 subjects aged 55.08±12.68 years who received olokizumab at a single dose of 160 mg/mL – 0.4 mL subcutaneously as a preemptive anti-inflammatory therapy. The comparison group included 511 subjects aged 55.23±11.23 years who received standard therapy without IL-6 inhibitors. Control Endpoints: 1. Positive clinical changes on Day 7. 2. Changes in the CRP levels on Days 1, 2, and 7. 3. Duration of oxygen therapy. 4. Number of days in hospital. 5. Number of adverse events. 6. Disease outcome.

Results. If a «cytokine storm» occurs, immune regulatory events will trigger the development of either a protective immune response or an exacerbated inflammatory response. The use of preemptive anti-inflammatory therapy has both a short-term and, most importantly, a long-term effect on the T and B parts of the immune process. These aspects definitely require further research and observation.

Conclusion. The use of olokizumab to treat the new COVID-19 coronavirus disease has demonstrated a positive effect on clinical and laboratory parameters. Primarily, it affects the severity of clinical parameters by improving the general condition already on the first day of observation, and decreasing body temperature to normal values. The changes in the C-reactive protein levels show a significant effect of the IL-6 inhibitor on the systemic inflammatory response.

作者简介

V. Antonov

South Ural State Medical University; Regional Clinical Hospital №3

编辑信件的主要联系方式.
Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-3531-3491

д.м.н., проф. каф.

俄罗斯联邦, Chelyabinsk

G. Ignatova

South Ural State Medical University; Regional Clinical Hospital №3

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-0877-6554

д.м.н., проф., зав. каф

俄罗斯联邦, Chelyabinsk

O. Pribytkova

South Ural State Medical University; Regional Clinical Hospital №3

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-0818-9237

к.м.н., зав. отд-нием, гл. внештатный специалист

俄罗斯联邦, Chelyabinsk

S. Sleptsova

Ammosov North-Eastern Federal University

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-0103-4750

д.м.н., доц., зав. каф

俄罗斯联邦, Yakutsk

E. Strebkova

Seredavin Samara Regional Clinical Hospital; Samara State Medical University, Samara

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-0854-2264

к.м.н., доц., зав. отд-нием, внештатный специалист

俄罗斯联邦, Samara

E. Khudyakova

. Luke of Crimea Stary Oskol District Hospital, Belgorod Region

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-4408-1581

зав. отд-нием

俄罗斯联邦, Stary Oskol

A. Simakov

Pacific State Medical University; Territorial Clinical Hospital №2

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-3334-4673

д.м.н., доц., зав. каф. внештатный специалист

俄罗斯联邦, Vladivostok

S. Rabets

Norilsk Inter-District Hospital №1

Email: ant-vn@yandex.ru
ORCID iD: 0000-0003-4853-4127

зам. глав. врача, клинический фармаколог

俄罗斯联邦, Norilsk

E. Tikhonova

Voyno-Yasenetsky Krasnoyarsk State Medical University; Karpovich Krasnoyarsk Inter-District Clinical Emergency Hospital

Email: ant-vn@yandex.ru
ORCID iD: 0000-0001-6466-9609

д.м.н., проф., зав. каф

俄罗斯联邦, Krasnoyarsk

D. Kurmaeva

Penza Regional Clinical Tertiary Care Centre

Email: ant-vn@yandex.ru
ORCID iD: 0000-0001-7989-7647

к.м.н., зам. глав. врача

俄罗斯联邦, Penza

M. Petrushin

Tver Region Regional Clinical Hospital

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-2780-5138

зав. отд-нием

俄罗斯联邦, Tver

A. Mashkov

Voronovskoye Moscow Clinical Center for Infectious Diseases

Email: ant-vn@yandex.ru
ORCID iD: 0000-0003-3465-8372

зав. отд-нием

俄罗斯联邦, Moscow

E. Gayazova

Nizhny Novgorod Region City Clinical Hospital №3 (Nizhny Novgorod Geriatric Center)

Email: ant-vn@yandex.ru
ORCID iD: 0000-0001-9621-3550

врач-невролог

俄罗斯联邦, Nizhny Novgorod

I. Yasheva

Temporary Infectious Diseases Hospital for Coronavirus Disease based at the Cherkess City Clinical Hospital

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-2228-5137

зав. отд-нием

俄罗斯联邦, Cherkessk

M. Andreev

Republican Tuberculosis Dispensary

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-4548-2598

зам. глав. врача

俄罗斯联邦, Cheboksary

V. Khinovker

Siberian Clinical Research Center

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-3162-6298

к.м.н., зав. отд-нием

俄罗斯联邦, Krasnoyarsk

A. Karpunin

Regional Clinical Hospital

Email: ant-vn@yandex.ru
ORCID iD: 0000-0003-0837-8895

к.м.н., глав. врач

俄罗斯联邦, Ryazan

B. Berezhanskiy

R-Pharm JSC

Email: ant-vn@yandex.ru
ORCID iD: 0000-0002-2551-9584

к.м.н., ст. мед. советник

俄罗斯联邦, Moscow

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