Administration of the immunomodulatory drug aminodihydrophthalazinedione sodium for prevention of progression pneumonia induced COVID-19
- 作者: Svistunov A.1, Makhnach G.1, Bunina D.1, Khorobrykh T.1, Volgin M.1, Agadzhanov V.1, Mishchenko N.1, Gandybina E.1
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 92, 编号 11 (2020)
- 页面: 65-70
- 栏目: Clinical notes
- URL: https://journals.rcsi.science/0040-3660/article/view/56939
- ID: 56939
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全文:
详细
Aim – to determine the efficacy of drug aminodihydrophthalazinedione sodium (Galavit) for prevention of progression of the coronavirus infection pulmonary complications: acceleration of regression of pulmonary infiltrates and resolution of COVID-induced pneumonia. 22 patients with medium and severe COVID-induced pneumonia were included in the study. The study included 8 men and 14 women, the average age was 62.1±7.4 years. Patients with more than one adverse prognostic factor made 82%. Average volume of pulmonary tissue affection (computer tomography – CT-2, 25–50% of lung volume) was registered in 13 (59.1%) patients, significant volume (CT-3, 50–75% of lung volume), in 9 (40.9%) patients. All patients had progressive respiratory failure manifestations due to hypoxemia and related diseases. Aminodihydrophthalazinedione sodium was administered for 7–14 days from the beginning of disease, at the end of the course of standard complex therapy, in case of preservation of signs of intoxication, negative dynamics according to computer tomography data. Administration of aminodihydrophthalazinedione sodium had a positive effect on the dynamics of clinical scores. The progression of respiratory failure was halted and there was an increase in SpO2 values. According to the control computer tomography data the stabilization of the pulmonary parenchyma affection degree was noted, as well as reduction of the size of the compacted areas in the pulmonary tissue and formation of the picture of organising pneumonia that contributed to reduction of respiratory failure grade. The use of aminodihydrophthalazinedione sodium in complex therapy of COVID-induced pneumonia has a modulating effect on the immune system, prevents the progression of pulmonary tissue affection, promotes regression of infiltration foci, preventing the development of excessive pneumofibrosis and the progression of respiratory failure.
作者简介
A. Svistunov
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0003-1592-5703
чл.-кор. РАН, д.м.н., проф., первый проректор
俄罗斯联邦, MoscowG. Makhnach
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0002-4820-3654
к.м.н., доц. каф. пульмонологии
俄罗斯联邦, MoscowD. Bunina
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0002-5646-765X
врач-пульмонолог
俄罗斯联邦, MoscowT. Khorobrykh
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0001-5769-5091
проф. РАН, д.м.н., проф., зав. каф. факультетской хирургии №2
俄罗斯联邦, MoscowM. Volgin
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0001-6197-6814
клин. ординатор каф. факультетской хирургии №2
俄罗斯联邦, MoscowV. Agadzhanov
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0002-4068-8431
к.м.н., доц. каф. факультетской хирургии №2
俄罗斯联邦, MoscowN. Mishchenko
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0002-4205-7748
клин. ординатор каф. факультетской хирургии №2
俄罗斯联邦, MoscowE. Gandybina
Sechenov First Moscow State Medical University (Sechenov University)
Email: nataschamishchenko@yandex.ru
ORCID iD: 0000-0002-6765-5154
к.м.н., доц. каф. факультетской хирургии №2
俄罗斯联邦, Moscow参考
- Fernandes AS, Lobo S, Sandes AR, et al. Vitamin D-dependent rickets: a resurgence of the rachitic lung in the 21st century. BMJ Case Rep. 2015 Oct 19;2015. pii: bcr2015212639. doi: 10.1136/bcr-2015-212639
- Dedicoat M. Where next with for vitamin D and tuberculosis? Int J Tuberc Lung Dis. 2020 Mar 1;24(3):265. doi: 10.5588/ijtld.20.0045
- Wang Y, Shi C, Yang Z, et al. Vitamin D deficiency and clinical outcomes related to septic shock in children with critical illness: a systematic review. Eur J Clin Nutr. 2019 Aug;73(8):1095-1101. doi: 10.1038/s41430-018-0249-0
- Sundaram ME, Coleman LA. Vitamin D and influenza. Adv Nutr. 2012;3(4):517-25. doi: 10.3945/an.112.002162
- Пигарова Е.А., Плещева А.В., Дзеранова Л.К. Влияние витамина D на иммунную систему. Иммунология. 2015; 36 (1): 62-6 [Pigarova EA, Pleshcheva AV, Dzeranova LK. The effect of vitamin D on the immune system. Immunology. 2015;36(1):62-6 (In Russ.)].
- Koivisto O, Hanel A, Carlberg C. Key Vitamin D Target Genes with Functions in the Immune System. Nutrients. 2020 Apr 19;12(4). pii: E1140. doi: 10.3390/nu12041140
- Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;10.1056/NEJMoa2001017. doi: 10.1056/NEJMoa2001017
- Zhong NS, Zheng BJ, Li YM, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003. Lancet. 2003;362:1353-8. doi: 10.1016/s0140-6736(03)14630-2
- Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369:407-16. doi: 10.1056/NEJMoa1306742
- Song Z, Xu Y, Bao L, et al. From SARS to MERS, Thrusting Coronaviruses into the Spotlight. Viruses 2019;11. doi: 10.3390/v11010059
- Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23:130-7. doi: 10.1111/resp.13196
- Britten R. The incidence of epidemic influenza, 1918–19. Public Health Rep. 1932;47:303-39.
- Лещенко И.В., Кривоногов А.В. Особенности течения пневмонии при пандемическом гриппе А/Н1N1/09. Пульмонология. 2011;6:62-8 [Leshchenko IV, Krivonogov AV. Features of the course of pneumonia in pandemic influenza A/H1N1/09. Pulmonology. 2011;6:62-8 (In Russ.)]. doi: 10.18093/0869-0189-2011-0-6-62-68
- Плещева А.В., Пигарова Е.А., Дзеранова Л.К. Витамин D и метаболизм: факты, мифы и предубеждения. Ожирение и метаболизм. 2012;9(2):33-42. [Pleshcheva AV, Pigarova EA, Dzeranova LK. Vitamin D and metabolism: facts, myths and prejudices. Obesity and metabolism. 2012;9(2):33-42 (In Russ.)]. doi: 10.14341/omet2012233-42
- Пигарова Е.А., Мазурина Н.В., Трошина Е.А. Витамин D в профилактике костных и метаболических нарушений. Consilium Medicum. 2019;21(4):84-90 [Pigarova EA, Mazurina NV, Troshina EA. Vitamin D in the prevention of bone and metabolic disorders. Consilium Medicum. 2019;21(4):84-90 (In Russ.)]. doi: 10.26442/20751753.2019.4.190342
- Пигарова Е.А., Поваляева А.А., Дзеранова Л.К., Рожинская Л.Я. Роль витамина D для профилактики и лечения рахита у детей. Педиатрия. Consilium Medicum. 2019;3:40-5. [Pigarova EA, Povalyaeva AA, Dzeranova LK, Rozhinskaya LYa. The role of vitamin D in the prevention and treatment of rickets in children. Pediatrics. Consilium Medicum. 2019;3:40-5 (In Russ.)]. doi: 10.26442/20751753.2019.4.190342
- Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50:194-200. doi: 10.1016/j.jcv.2010.12.006
- Gruber-Bzura BM. Vitamin D and Influenza – Prevention or Therapy? Int J Mol Sci. 2018;19(8):2419. doi: 10.3390/ijms19082419
- Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015;7:4240-70. doi: 10.3390/nu7064240
- Odroważ-Sypniewska G, Karczmarewicz E, Paprotny Ł, Płudowski P. 3-epi-25(OH)D – A new metabolite, potential biological function, interference in laboratory assays. Stand Med Pediatr. 2012;9:680-6.
- Пигарова Е.А., Петрушкина А.А. Неклассические эффекты витамина D. Остеопороз и остеопатии. 2017;20(3):90-101 [Pigarova EA, Petrushkina AA. Nonclassical effects of vitamin D. Osteoporosis and bone diseases. 2017;20(3):90-101 (In Russ.)].
- Christakos S, Hewison M, Gardner DG, et al. Vitamin D: Beyond bone. Ann N Y Acad Sci. 2013;1287:45-58. doi: 10.1111/nyas.12129
- Moukayed M, Grant WB. Molecular link between vitamin D and cancer prevention. Nutrients. 2013;5:3993-4021. doi: 10.3390/nu5103993
- Петрушкина А.А., Пигарова Е.А., Рожинская Л.Я. Эпидемиология дефицита витамина D в Российской Федерации. Остеопороз и остеопатии. 2018;21(3):15-20 [Petrushkina AA, Pigarova EA, Rozhinskaya LYa. Epidemiology of Vitamin D Deficiency in the Russian Federation. Osteoporosis and bone diseases. 2018;21(3):15-20 (In Russ.)]. doi: 10.14341/osteo10038
- Пигарова Е.А. Основные положения клинических рекомендаций Российской Ассоциации Эндокринологов «Дефицит витамина D у взрослых: диагностика, лечение и профилактика». Остеопороз и остеопатии. 2015;18(2):29-32 [Pigarova EA. The main provisions of the clinical recommendations of the Russian Association of Endocrinologists «Vitamin D deficiency in adults: diagnosis, treatment and prevention». Osteoporosis and bone diseases. 2015;18(2):29-32 (In Russ.)].
- Cashman KD, Sheehy T, O’Neill CM. Is vitamin D deficiency a public health concern for low middle income countries? A systematic literature review. Eur J Nutr. doi: 10.1007/s00394-018-1607-3
- Papadimitriou DT. The Big Vitamin D Mistake. J Prev Med Public Health. 2017 Jul;50(4):278-81. doi: 10.3961/jpmph.16.111
- Пигарова Е.А., Поваляева А.А., Дзеранова Л.К., Рожинская Л.Я. Роль витамина D в профилактике и лечении остеопороза – новый взгляд на известную проблему. Рус. мед. журнал. Медицинское обозрение. 2019;3(10-2):102-6 [Pigarova EA, Povalyaeva AA, Dzeranova LK, Rozhinskaya LYa. The role of vitamin D in the prevention and treatment of osteoporosis is a new look at a known problem. Rus honey. magazine. Medical Review. 2019;3(10-2):102-6 (In Russ.)].
- Kara M, Ekiz T, Ricci V, et al. ‘Scientific Strabismus’ or Two Related Pandemics: COVID-19 & Vitamin D Deficiency. Br J Nutr. 2020;1-20. doi: 10.1017/S0007114520001749
- Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of acute respiratory infection: systematic review of clinical studies. J Steroid Biochem Mol Biol. 2013;136:321-9. doi: 10.1016/j.jsbmb.2012.11.017
- Schwalfenberg GK. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol Nutr Food Res. 2011;55:96-108. doi: 10.1002/mnfr.201000174
- Laaksi I. Vitamin D and respiratory infection in adults. Proc Nutr Soc. 2012;71:90-7. doi: 10.1017/S0029665111003351
- Rossi GA, Fanous H, Colin AA. Viral strategies predisposing to respiratory bacterial superinfections. Pediatr. Pulmonol. 2020. doi: 10.1002/ppul.24699
- Agier J, Efenberger M, Brzezinska-Blaszczyk E. Cathelicidin impact on inflammatory cells. Cent Eur J Immunol. 2015;40:225-35. doi: 10.5114/ceji.2015.51359
- Grant WB, Lahore H, McDonnell SL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):988. doi: 10.3390/nu12040988
- Herr C, Shaykhiev R, Bals R. The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther. 2007;7:1449-61. doi: 10.1517/14712598.7.9.1449
- Szymczak I, Pawliczak R. The active metabolite of vitamin D3 as a potential immunomodulator. Scand J Immunol. 2015;83:83-91. doi: 10.1111/sji.12403
- Bikle DD. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016;1376:29-51. doi: 10.1111/nyas.13219
- Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015;7:4240-70. doi: 10.3390/nu7064240
- Handel AE, Sandve GK, Disanto G, et al. Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163. doi: 10.1186/1741-7015-11-163
- Kongsbak M, von Essen MR, Levring TB, et al. Vitamin D-binding protein controls T cell responses to vitamin D. BMC Immunol. 2014;15:35. doi: 10.1186/s12865-014-0035-2
- Ooi JH, McDaniel KL, Weaver V, Cantorna MT. Murine CD8+ T cells but not macrophages express the vitamin D 1alpha-hydroxylase. J Nutr Biochem. 2014;25:58-65. doi: 10.1016/j.jnutbio.2013.09.003
- Lee MD, Lin CH, Lei WT, et al. Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis. Nutrients. 2018;10(4):409. doi: 10.3390/nu10040409
- Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J. 2019;16:69. doi: 10.1186/s12985-019-1182-0
- Ramos-Martínez E, López-Vancell MR, Fernández de Córdova-Aguirre JC, et al. Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression. Cytokine. 2018;108:239-46. doi: 10.1016/j.cyto.2018.01.001
- Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5
- Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. doi: 10.1016/S0140-6736(20)30211-7
- Available from: https://www.bbc.com/russian/features-52839688
- Xu X, Han M, Li T, et al. Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci USA. 2020;117(20):10970-5. doi: 10.1073/pnas.2005615117
- Parlak E, Ertürk A, Çağ Y, et al. The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever. Int J Clin Exp Med. 2015;8:18302-10.
- Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420-2. doi: 10.1016/S2213-2600(20)30076-X
- Shi Y, Liu T, Yao LI, et al. Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system. Sci Rep. 2017;7(1):3312. doi: 10.1038/s41598-017-03474-6
- Hanff TC, Harhay MO, Brown TS, et al. Is there an association between COVID-19 mortality and the renin-angiotensin system – a call for epidemiologic investigations. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa329
- Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061. doi: 10.1001/jama.2020.1585
- Mohammad S, Mishra A, Ashraf MZ. Emerging role of vitamin D and its associated molecules in pathways related to pathogenesis of thrombosis. Biomolecules. 2019;9(11):649. doi: 10.3390/biom9110649
- Laird E, Rhodes J, Kenny RA. Vitamin D and Inflamation; potential implications for severity of Covid-19. Ir Med J. 2020;113(5):P81.
- Marik PE, Kory P, Varon J. Does vitamin D status impact mortality from SARS-CoV-2 infection? Med Drug Discov. 2020;100041. doi: 10.1016/j.medidd.2020.100041
- D’Avolio A, Avataneo V, Manca A, et al. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):E1359. doi: 10.3390/nu12051359
- Alipio M. Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19) (April 9, 2020). https://ssrn.com/abstract=3571484 or http://dx.doi.org/ 10.2139/ssrn.3571484
- Raharusun P, Sadiah P, Budiarti C, et al. Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study (April 26, 2020). https://ssrn.com/abstract=3585561 or http://dx.doi.org/10.2139/ssrn.3585561
- Jakovac H. COVID-19 and vitamin D-Is there a link and an opportunity for intervention? Am J Physiol Endocrinol Metab. 2020;318(5):E589. doi: 10.1152/ajpendo.00138.2020
- Лесняк О.М., Никитинская О.А., Торопцова Н.В. и др. Профилактика, диагностика и лечение дефицита витамина D и кальция у взрослого населения России и пациентов с остеопорозом (по материалам подготовленных клинических рекомендаций). Научно-практическая ревматология. 2015;53(4):403-8. [Lesnyak OM, Nikitinskaya OA, Toroptsova NV, et al. The prevention, diagnosis, and treatment of vitamin d and calcium deficiencies in the adult population of russia and in patients with osteoporosis (according to the materials of prepared clinical recommendations). Scientific and practical rheumatology. 2015;53(4):403-8 (In Russ.)]. doi: 10.14412/1995-4484-2015-403-408
- Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е. и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60-84 [Pigarova EA, Rozhinskaya LYa, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of endocrinology. 2016;62(4):60-84 (In Russ.)]. doi: 10.14341/probl201662460-84
- Heaney RP, Davies KM, Chen TC, et al. Human serum 25-hydroxychole-calciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10. doi: 10.1093/ajcn/77.1.204