Relationship of visceral obesity and coronary calcinosis in ischemic heart disease
- 作者: Brel N.1, Gruzdeva O.1,2, Kokov A.1, Masenko V.1, Dyleva Y.1, Belik E.1, Barbarash O.1,2
-
隶属关系:
- Research Institute for Complex Issues of Cardiovascular Diseases
- Kemerovo State Medical University
- 期: 卷 93, 编号 12 (2021)
- 页面: 1428-1434
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/38726
- DOI: https://doi.org/10.26442/00403660.2021.12.201277
- ID: 38726
如何引用文章
全文:
详细
Aim. To assess the relationship between the prevalence of visceral obesity (VO) and the severity of coronary calcification (CC) in patients with verified coronary artery disease (CAD).
Materials and methods. 125 patients with CAD were examined. Assessment of the morphometric characteristics of visceral adipose tissue (VAT) and CC was perform using multislice computed tomography (MSCT). The calcium index (CI) of the coronary arteries (CA) was determine by the Agatston method. Statistical analysis was perform using Statistica 10.0.
Results. VO was detect in 82 (65.6%) patients with CAD. In the presence of VO, higher CC values were observed in the projection of the envelope (p=0.00014), right coronary (p=0.00002) arteries, total CI (p=0.0003), and the prevalence of massive CC. Correlation analysis showed the relationship between the area of VAT and the CC of all the studied localizations. According to the ROC analysis, VO is a significant predictor of massive CC (area under the ROC curve – AUC 0.72, 95% CI 0.56–0.89), in contrast to body mass index – BMI (AUC 0.56, 95% CI 0.31–0.82).
Conclusion. The index of the ratio of VAT to subcutaneous adipose tissue (VAT/SAT), but not BMI, had a direct correlation with CC. Morphology of VAT may be a significant diagnostic sign of massive CC in patients with CAD, as a factor affecting treatment and prognosis.
作者简介
Natalia Brel
Research Institute for Complex Issues of Cardiovascular Diseases
Email: brel.n.k@mail.ru
ORCID iD: 0000-0002-5643-4022
SPIN 代码: 3401-4062
мл. науч. сотр. лаб. лучевых методов диагностики
俄罗斯联邦, KemerovoOlga Gruzdeva
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University
编辑信件的主要联系方式.
Email: o_gruzdeva@mail.ru
ORCID iD: 0000-0002-7780-829X
д-р мед. наук, зав. лаб. исследований гомеостаза, проф. каф. патологической физиологии
俄罗斯联邦, Kemerovo; KemerovoAlexander Kokov
Research Institute for Complex Issues of Cardiovascular Diseases
Email: dr.kokov@gmail.com
ORCID iD: 0000-0002-7573-0636
канд. мед. наук, зав. лаб. лучевых методов диагностики
俄罗斯联邦, KemerovoVladislava Masenko
Research Institute for Complex Issues of Cardiovascular Diseases
Email: radiology@bk.ru
ORCID iD: 0000-0003-3970-4294
SPIN 代码: 5437-0710
Scopus 作者 ID: 56188576400
канд. мед. наук, науч. сотр. лаб. лучевых методов диагностики
俄罗斯联邦, KemerovoYulia Dyleva
Research Institute for Complex Issues of Cardiovascular Diseases
Email: sionina.ev@mail.ru
ORCID iD: 0000-0002-6890-3287
канд. мед. наук, ст. науч. сотр. лаб. исследований гомеостаза
俄罗斯联邦, KemerovoEkaterina Belik
Research Institute for Complex Issues of Cardiovascular Diseases
Email: sionina.ev@mail.ru
ORCID iD: 0000-0003-3996-3325
канд. мед. наук, мл. науч. сотр. лаб. исследований гомеостаза
俄罗斯联邦, KemerovoOlga Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University
Email: mein11@mail.ru
ORCID iD: 0000-0002-4642-3610
SPIN 代码: 5373-7620
Researcher ID: A-4834-2017
чл.-кор. РАН, д-р мед. наук, проф., дир., зав. каф. кардиологии и сердечно-сосудистой хирургии
俄罗斯联邦, Kemerovo; Kemerovo参考
- Roth GA, Johnson C, Abajobir A, et al. Global regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am College Cardiol. 2017;70(1):1-25. doi: 10.1016/j.jacc.2017.04.052
- Dugani S, Gaziano TA. 25 by 25: achieving global reduction in cardiovascular mortality. Curr Cardiol Rep. 2016;18(1):10. doi: 10.1007/s11886-015-0679-4
- Муромцева Г.А., Концевая А.В., Константинов В.В., и др. Распространенность факторов риска неинфекционных заболеваний в российской популяции в 2012–2013 гг. Результаты исследования ЭССЕ-РФ. Кардиоваскулярная терапия и профилактика. 2014;13(6):4-11 [Muromtseva GA, Kontsevaya AV, Konstantinov VV, et al. The prevalence of non-infectious diseases risk factors in Russian population in 2012–2013 years. The results of ECVD-RF. Cardiovascular Therapy and Prevention. 2014;13(6):4-11 (in Russian)]. doi: 10.15829/1728-8800-2014-6-4-11
- Britton KA, Massaro JM, Murabito JM, et al. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J Am Coll Cardiol. 2013;62(10):921-5. doi: 10.1016/j.jacc.2013.06.027
- Rozanski A, Gransar H, Shaw LJ, et al. Impact of coronary artery calcium scanning on coronary risk factors and downstream testing: the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) prospective randomized trial. J Am Coll Cardiol. 2011;57(15):1622-32. doi: 10.1016/j.jacc.2011.01.019
- McClelland RL, Jorgensen NW, Budoff M, et al. 10-Year Coronary Heart Disease Risk Prediction Using Coronary Artery Calcium and Traditional Risk Factors: Derivation in the MeSA (Multi-Ethnic Study of Atherosclerosis) With Validation in the HNR (Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study). J Am Coll Cardiol. 2015;66(15):1643-53. doi: 10.1016/j.jacc.2015.08.035
- Matsuzawa Y, Nakamura T, Shimomura I, Kotani K. Visceral fat accumulation and cardiovascular disease. Obes Res. 1995;3(Suppl. 5):645-7. doi: 10.1002/j.1550-8528.1995.tb00481.x
- Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15(4):827-32. doi: 10.1016/0735-1097(90)90282-T
- Коков А.Н., Брель Н.К., Масенко В.Л., и др. Количественная оценка висцерального жирового депо у больных ишемической болезнью сердца с использованием современных томографических методик. Комплексные проблемы сердечно-сосудистых заболеваний. 2017;3:113-9 [Kokov AN, Brel NK, Masenko VL, et al. Quantitative assessment of visceral adipose depot in patients with ischemic heart disease by using of modern tomographic Methods. Complex Issues of Cardiovascular Diseases. 2017;3:113-9 (in Russian)]. doi: 10.17802/2306-1278-2017-6-3-113-119
- Hung SP, Chen CY, Guo FR, et al. Combine body mass index and body fat percentage Measures to improve the accuracy of obesity screening in young adults. Obes Res Clin Pract. 2017;11(1):118. doi: 10.1016/j.orcp.2016.02.005
- Груздева О.В., Акбашева О.Е., Бородкина Д.А., и др. Взаимосвязь показателей ожирения и адипокинов с риском развития сахарного диабета 2 типа через год после перенесенного инфаркта миокарда. Российский кардиологический журнал. 2015;4:59-67 [Gruzdeva OV, Akbasheva OE, Borodkina DA, et al. Relationship of obesity parameters and adipokines with the risk of 2nd type diabetes development in a year after myocardial infarction. Russian Journal of Cardiology. 2015;4:59-67 (in Russian)]. doi: 10.15829/1560-4071-2015-4-59-67
- Tang L, Zhang F, Tong N. The association of visceral adipose tissue and subcutaneous adipose tissue with Metabolic risk factors in a large population of Chinese adults. Clin Endocrinol (Oxf). 2016;85(1):46-53. doi: 10.1111/cen.13013
- Bourantas CV, Zhang YJ, Garg S, et al. Prognostic implications of coronary calcification in patients with obstructive coronary artery disease treated by percutaneous coronary intervention: a patient-level pooled analysis of 7 contemporary stent trials. Heart. 2014;100(15):1158-64. doi: 10.1136/heartjnl-2013-305180
- Zhang Y, Song L, Song Y, et al. Impact of coronary artery lesion calcification on the long-term outcome of patients with coronary heart disease after percutaneous coronary intervention. Zhonghua Xin Xue Guan Bing Za Zhi. 2019;47(1):34‐41. doi: 10.3760/cma.j.issn.0253-3758.2019.01.004
- Ertelt K, Généreux P, Mintz GS, et al. Impact of the severity of coronary artery calcification on clinical events in patients undergoing coronary artery bypass grafting (from the Acute Catheterization and Urgent Intervention Triage Strategy Trial). Am J Cardiol. 2013;112(11):1730‐7. doi: 10.1016/j.amjcard.2013.07.038
- Зыков М.В., Хрячкова О.Н., Кашталап В.В., и др. Динамика коронарной кальцификации и ее связь с клиническим течением ишемической болезни сердца и остеопеническим синдромом. Кардиология. 2019;59(4):12-20 [Zykov MV, Hryachkova ON, Kashtalap VV, et al. Dynamics of Coronary Calcification and Its Association with the Clinical Course of Ischemic Heart Disease and Osteopenic Syndrome. Kardiologiia. 2019;59(4):12-20 (in Russian)]. doi: 10.18087/cardio.2019.4.10247
- Gruzdeva O, Uchasova E, Dyleva Y, et al. Adipocytes Directly Affect Coronary Artery Disease Pathogenesis via Induction of Adipokine and Cytokine Imbalances. Front Immunol. 2019;10:2163. doi: 10.3389/fimmu.2019.02163
- Park HJ, Kim J, Park SE, et al. Increased risk of subclinical atherosclerosis associated with high visceral adiposity index in apparently healthy Korean adults: the Kangbuk Samsung Health Study. Ann Med. 2016;48(6):410-6. doi: 10.1080/07853890.2016.1183258
- Larsen BA, Laughlin GA, Cummins K, et al. Adipokines and severity and progression of coronary artery calcium: Findings from the Rancho Bernardo Study. Atherosclerosis. 2017;265:1-6. doi: 10.1016/j.atherosclerosis.2017.07.022
- Cardoso L, Weinbaum S. Microcalcifications, Their Genesis, Growth, and Biomechanical Stability in Fibrous Cap Rupture. Adv Exp Med Biol. 2018;1097:129-55. doi: 10.1007/978-3-319-96445-4_7
- Nadra I, Mason JC, Philippidis P, et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res. 2005;96(12):1248-56. doi: 10.1161/01.RES.0000171451.88616.c2
- Lee MJ, Park JT, Park KS, at al. Normal body mass index with central obesity has increased risk of coronary artery calcification in Korean patients with chronic kidney disease. Kidney Int. 2016;90(6):1368-76. doi: 10.1016/j.kint.2016.09.011
- Folsom AR, Kronmal RA, Detrano RC, et al. Coronary artery calcification compared with carotid intima-media thickness in prediction of cardiovascular disease incidence: The Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med. 2008;168(12):1333-9. doi: 10.1001/archinte.168.12.1333