Invasive aspergillesis in immunocompromised patients

G A Klyasova; Клясова Г А; N A Petrova; Петрова Н А; G M Galstyan; Галстян Г М; L N Gotman; Готман Л Н; E S Vishnevskaya; Вишневская Е С; E P Sysoeva; Сысоева Е П; N D Khoroshko; Хорошко Н Д; E A Mikhailova; Михайлова Е А; E N Parovichnikova; Паровичникова Е Н; V G Isaev; Исаев В Г; E N Ustinova; Устинова Е Н; A M Kremenetskaya; Кременецкая А М; S K Kravchenko; Кравченко С К; E N Glasko; Гласко Е Н; I В Kaplanskaya; Капланская И Б; M A Vernyuk; Вернюк М А; E O Krasnova; Краснова Е О; S V Shavlokhov; Шавлохов С В; V V Ryzhko; Рыжко В В; V G Savchenko; Савченко В Г

Invasive aspergillesis in immunocompromised patients

作者: Klyasova GA¹, Petrova NA¹, Galstyan GM¹, Gotman LN¹, Vishnevskaya ES¹, Sysoeva EP¹, Khoroshko ND¹, Mikhailova EA¹, Parovichnikova EN¹, Isaev VG¹, Ustinova EN¹, Kremenetskaya AM¹, Kravchenko SK¹, Glasko EN¹, Kaplanskaya IВ¹, Vernyuk MA¹, Krasnova EO¹, Shavlokhov SV¹, Ryzhko VV¹, Savchenko VG¹
隶属关系:
1. ТНЦ РАМН, Москва
期: 卷 78, 编号 7 (2003)
页面: 63-68
栏目: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/33375
ID: 33375

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Aim. To analyse results of treatment of invasive aspergillesis in immunocompromised patients for
2000-2002.
Material and methods. The study was made of patients who, when treated with antibiotics, exhibited
foci in the lungs typical for invasive aspergillesis. Aspergillus were detected in the sputum, bronchoalveolar
lavage, bronchial wash-ups, aspergilla antigen (galactomannan) was detected in the blood.
Results. Invasive aspergillesis was diagnosed in 25 patients. 13 (52%) patients were treated with adjuvant
glucocorticoids. 19 (76%) patients had neutropenia. All the patients had fever. Foci in the lungs
were in 24 patients. Aspergillus were detected in 15 patients, a positive antigen galactomannan in 7 patients.
A. Fumigatus, A flavus, A. Niger occurred in 67, 26.5 and 6.5% patients, respectively. All the patients
received amphotericin В (median of the treatment reached 38 days, total dose 880-3500 mg). In
5 patients amphotericin В was replaced for liposomal amphotericin В because of high creatinine. 7 patients
continued with itraconasol in a dose 400-600mg/day. The foci were removed in 3 patients. The
cure was achieved in 12 patients, 13 patients died (cause of death - respiratory insufficiency).
Conclusion. Lethality in invasive aspergillesis in immunocompromised patients remains high - 52%.
Cultural detection of mycelial fungi was, as a rule, delayed. Early diagnosis of the disease requires
monitoring of the aspergilla antigen in the blood and computer tomography of the chest especially in
fever persisting in the treatment of wide-spectrum antibiotics.

关键词

aspergillesis, neutropenia, acute leukemia, therapy, immunocompromised patients

参考

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Invasive aspergillesis in immunocompromised patients

全文:

详细

关键词

作者简介

G Klyasova

N Petrova

G Galstyan

L Gotman

E Vishnevskaya

E Sysoeva

N Khoroshko

E Mikhailova

E Parovichnikova

V Isaev

E Ustinova

A Kremenetskaya

S Kravchenko

E Glasko

I Kaplanskaya

M Vernyuk

E Krasnova

S Shavlokhov

V Ryzhko

V Savchenko

参考

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