Whipple’s disease: A clinical case report

L M Krums; Крумс Л М; N A Bodunova; Бодунова Н А; E A Sabelnikova; Сабельникова Е А; S G Khomeriki; Хомерики С Г; K M Mirzoev; Мирзоев К М; M S Sokolova; Соколова М С; A I Parfenov; Парфенов А И

doi:10.17116/terarkh2017892103-104

Whipple’s disease: A clinical case report

作者: Krums L¹, Bodunova N¹, Sabelnikova E¹, Khomeriki S¹, Mirzoev K¹, Sokolova M¹, Parfenov A¹
隶属关系:
1. Московский клинический научно-практический центр ДЗМ
期: 卷 89, 编号 2 (2017)
页面: 103-104
栏目: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/32236
DOI: https://doi.org/10.17116/terarkh2017892103-104
ID: 32236

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The paper describes a 56-year-old female patient who in December 2015 lost her appetite and 20 kg of weight, had diarrhea, rapidly increasing weakness, dizziness, joint pains, fever, swelling of the feet, and convulsions. Blood tests revealed anemia, elevated erythrocyte sedimentation rate, and hypoproteinemia. Computed tomography showed enlarged mesenteric and retroperitoneal lymph nodes. The doctor suspected lymphoma and referred her to the Moscow Clinical Research Center. The diagnosis of Whipple’s disease was established by carrying out a small intestinal (duodenal) mucosal biopsy with the PAS reaction. A fat-free diet and antibiotic therapy with co-trimoxazole 2.0 g/day and ciprolen 0.3 g/day were prescribed for the patient. Fever and diarrhea disappeared, appetite appeared, weight gained, and blood counts normalized over 1 month of treatment. The patient was discharged with a recommendation to continue antibiotic treatment until the histopathological signs of the disease ceased.

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Whipple’s disease, rare diseases, diagnosis, co-trimoxazol, ciprolet

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Gunther U, Moos V, Offenmüller G, Oelkers G, Heise W, Moter A, Loddenkemper C, Schneider T. Gastrointestinal Diagnosis of Classical Whipple Disease: Clinical, Endoscopic, and Histopathologic Features in 191 Patients». Medicine (Baltimore). 2015;94(15):714.
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Крумс Л.М., Сабельникова Е.А., Чикунова Б.З., Парфенов А.И. Болезнь Уиппла у больного детским церебральным параличом и циррозом печени В-вирусной этиологии Тер. архив. 2014;86(2):69-71.
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Feurle GE, Moos V, Blaker H, et al. Intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in Whipple’s disease. J Infect. 2013;66:263-270.
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Whipple’s disease: A clinical case report

全文:

详细

关键词

全文:

作者简介

L Krums

N Bodunova

E Sabelnikova

S Khomeriki

K Mirzoev

M Sokolova

A Parfenov

参考