Location of foci in cerebral toxoplasmosis in HIV-infected patients
- 作者: Ermak T1, Peregudova A2
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隶属关系:
- ФБУН "Центральный НИИ эпидемиологии" Роспотребнадзора
- ГКУЗ ИКБ №2, Москва
- 期: 卷 86, 编号 11 (2014)
- 页面: 24-28
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31648
- ID: 31648
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AIM. To analyze the data of magnetic resonance imaging (MRI) of the brain in its toxoplasmosis in HIV-infected patients. Subject and methods. The clinical picture of cerebral toxoplasmosis was studied in 207 patients aged 18-76 years with Stage 4B HIV infection concurrent with the disease. Brain MRI using an Obraz-1 low-field (0.12 T) MRI scanner (Russia) was carried out in 115 (55.5%) patients. This investigation was conducted in 74 (65%) treated patients over time. RESULTS. Brain T2-weighted and FLAR MRI scans most frequently revealed higher-signal polymorphic foci and T1-weighted MRI scans showed lower-signal ones predominantly involving the white matter or white-grey matter border. Perifocal edema was often recorded. Intravenous gadolinium contrast study indicated that these foci accumulated the contrast agent around the periphery following the target patterns. Sixty-four (86.5%) patients were observed to have significant positive changes: reductions in the number and sizes of foci and the area of perifocal edema; in 29 patients, the inflammatory foci changed into cysts as a favorable outcome of necrotizing encephalitis. The foci resolved completely only in 7% of the patients. CONCLUSION. MRI is of great importance in intensive care, neurology, or neurosurgery units where patients with cerebral toxoplasmosis mimicking an acute cerebrovascular accident or a brain tumor are particularly frequently admitted to.
作者简介
T Ermak
ФБУН "Центральный НИИ эпидемиологии" Роспотребнадзора
Email: ermak@hivrussia.net
111123 Москва, Новогиреевская ул., 3а
A Peregudova
ГКУЗ ИКБ №2, Москва
参考
- Ермак Т.Н., Перегудова А.В. Многоликий портрет токсоплазмоза при ВИЧ-инфекции. Инфекц бол 2014; 1: 87-92.
- Jayawardena S., Singh S., Burzyantseva O., Clark H. Cerebral Toxoplasmosis in Adult Patients with HIV Infection. Hospital Physician 2008; 44 (7): 17-24.
- Иванова Л.Л., Зембатова С.Х., Дзуцева Ф.К., Борисенко Ю.Б. Хронический приобретенный токсоплазмоз с поражением головного мозга. Матер. V Ежегодного Всерос Конгр по инфекционным болезням. Инфекц бол 2013; 11 (Приложение 1): 165.
- Gray F., Gherardi R., Wingate E. et al. Diffuse "encefalitic" cerebral toxoplasmosis in AIDS. J Neurol 1989; 236 (5): 273-277.