Thrombin-activated inhibitor of fibrinolysis and efficacy and safety of long-term warfarin treatment in patients with venous thromboembolic complications
- 作者: Vorob'eva N.1, Panchenko E.1, Dobrovol'skiy A.1, Titaeva E.1, Ermolina O1, Balakhonova T1, Khasanova Z.1, Postnov A.1, Kirienko A.2, Vorobyeva N3, Panchenko E3, Dobrovolsky A3, Titaeva E3, Ermolina O3, Balakhonova T3, Khasanova Z3, Postnov A3, Kirienko A4
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隶属关系:
- ФГУ РКНПК Минздравсоцразвития
- РГМУ им. Н. И. Пирогова
- Russian Research Cardiology Center, Moscow
- N. I. Pirogov Russian State Moscow University, Moscow
- 期: 卷 83, 编号 12 (2011)
- 页面: 43-48
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30947
- ID: 30947
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Results. A TAFI level varied from 50 to 217% (median 106%, interquartile rage 90-133%). TAFI concentration positively correlated with fibrinogen and thromb size. The patients were divided into two groups depending on TAFI content: group 1 patients had low TAFI (under 25th percentile; < 90%); patients of group 2 had high TAFI (above 25th percentile; > 90%). Group 1 patients were characterized by less stable anticoagulation. This association did not depend on genetic characteristics which determine sensitivity to warfarin (CYP2C9 and VKORC1). Low TAFI was associated with reduced risk of DVT for 18 months and higher probability of complete lysis of the thrombi after 12 months of anticoagulant therapy compared to VTEC patients with high TAFI. No differences were found by TAFI level in patients with HC and without HC, but in HC patients low TAFI was associated with spontaneous hemorrhages and bleeding in therapeutic INR values.
Conclusion. The results of this pilot study evidence that a TAFI level can be one of the factors influencing efficacy and safety of long-term anticoagulant therapy in patients with VTEC on warfarin treatment.
作者简介
Natal'ya Vorob'eva
ФГУ РКНПК Минздравсоцразвития
Email: natalyavorobjeva@mail.ru
канд. мед. наук, ст. науч. сотр. лаб. мед. генетики РКНПК МЗиСР РФ, тел.: 8-495-414-65-13; ФГУ РКНПК Минздравсоцразвития
Elizaveta Panchenko
ФГУ РКНПК Минздравсоцразвития
Email: lizapanchenko@mail.ru
д-р мед. наук проф., руководитель лаб. клин. проблем атеротромбоза отд. ангиологии ФГУ РКНПК, тел.: 8-495-414-63-04; ФГУ РКНПК Минздравсоцразвития
Anatoliy Dobrovol'skiy
ФГУ РКНПК Минздравсоцразвития
Email: abdobrovolsky@inbox.ru
д-р биологических наук, проф., вед. науч. сотр. лаб. клин. проблем атеротромбоза отд. ангиологии ФГУ РКНПК, тел.: 8-495-414-66-30; ФГУ РКНПК Минздравсоцразвития
Elena Titaeva
ФГУ РКНПК Минздравсоцразвития
Email: evlti@mail.ru
канд. биол. наук, ст. науч. сотр. лаб. клин., проблем атеротромбоза отд. ангиологии ФГУ РКНПК, тел.: 8-495-414-64-69; ФГУ РКНПК Минздравсоцразвития
O Ermolina
ФГУ РКНПК МинздравсоцразвитияФГУ РКНПК Минздравсоцразвития
T Balakhonova
ФГУ РКНПК МинздравсоцразвитияФГУ РКНПК Минздравсоцразвития
Zukhra Khasanova
ФГУ РКНПК Минздравсоцразвития
Email: khasanova@mail.ru
мл. науч. сотр. лаб. мед. генетики ФГУ РКНПК, тел.: 8-495-414-65-87; ФГУ РКНПК Минздравсоцразвития
Anton Postnov
ФГУ РКНПК Минздравсоцразвития
Email: anton-5@mail.ru
д-р мед. наук, рук. лаб. мед. генетики ФГУ РКНПК, тел.: 8-495-414-60-98; ФГУ РКНПК Минздравсоцразвития
Aleksandr Kirienko
РГМУ им. Н. И. Пирогова
Email: phlebo-union@mtu-net.ru
д-р мед. наук, проф., член-кор. РАМН, проф. каф. факультетской хирургии РГМУ им. Н. И. Пирогова, тел.: 8-495-236-02-49; РГМУ им. Н. И. Пирогова
N Vorobyeva
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
E Panchenko
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A Dobrovolsky
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
E Titaeva
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
O Ermolina
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
T Balakhonova
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
Z Khasanova
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A Postnov
Russian Research Cardiology Center, MoscowRussian Research Cardiology Center, Moscow
A Kirienko
N. I. Pirogov Russian State Moscow University, MoscowN. I. Pirogov Russian State Moscow University, Moscow
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