Efficiency of the ALL-MB-2002 protocol in children with acute lymphoblastic leukemia
- 作者: Rumyantseva Y.1, Karachunsky A1, Aleinikova O2, Fechina L3, Shamardina A4, Litvinov D5, Ponomareva N5, Boichenko E6, Dudkin S7, Streneva O3, Kondratchik K8, Mansurova E1, Minkina L9, Lapotentova E2, Inyushkina E10, Yudina N11, Pavlova G12, Zhukovskaya E13, Khlebnikova O3, Lagoiko S1, Basharova E13, Denisov R13, Zlobina V14, Banshchikova E15, Aslanyan K16, Kondakova E17, Tselousova E18, Myakova N5, Turobova T19, Ryskal O20, Chipsanova N21, Varfolomeyeva S1, Rumyantsev A1
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隶属关系:
- Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
- Republican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, Belarus
- Center of Oncology and Hematology, Regional Children's Hospital One, Yekaterinburg
- Regional Children's Hospital, Nizhni Novgorod
- Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, Moscow
- Children's Hospital One, Saint Petersburg
- Town Children's Hospital Four, Novokuznetsk
- Morozov City Children's Hospital, Moscow
- Children's Town Hospital, Vladivostok
- Moscow Regional Cancer Dispensary, Balashikha, Moscow Region
- Regional Children's Hospital One, Voronezh
- Regional Children's Hospital, Ministry of Health and Social Development of Chuvash Republic, Cheboksary
- Regional Children's Hospital, Chelyabinsk
- Central District Hospital, Novosibirsk
- Regional Hospital One - NCM (National Center of Medicine), Yakutsk
- Regional Children's Hospital, Rostov-on-Don
- Surgut District Hospital, UHMAU-Ugry, Surgut
- Kirov Research Institute of Hematology and Blood Transfusion
- Regional Children's Hospital, Arkhangelsk
- Regional Children's Hospital, Perm
- Komi Republican Cardiology Dispensary, Syktyvkar
- 期: 卷 82, 编号 7 (2010)
- 页面: 11-19
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30592
- ID: 30592
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Subjects and methods. A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008.
Results. With the median observation of 4.12 years, 7-year event-free survival (EFS) was 73±13%; overall survival (OS) 78±2%; relapse-free survival 82±1%. The rates of EFS and OS were equal and amounted to 76±2 and 80±2% in the standard-risk group (SRG) and intermediate-risk group (ImRG), respectively. In the high-risk group (HRG) patients, EFS and OS were as high as 30±6 and 37±6%, respectively. The frequency of relapses with central nervous system lesion was as much as 4.7% in all the patients, 6-year cumulative risk for isolated neurorecurrences being 2.5% in the SRG patients. Adolescents, patients with the baseline leukocytosis (more than 100109/l), and those with a splenic size of over 4 cm or more from the costal arch margin had substantially worse survival rates. A poor early response to therapy (on induction days 8 and 15) was also associated with its lower efficiency.
Conclusion. Despite a considerable rise in the number of centers and a slight increase in the intensity of therapy, the results of the new ALL-MB-2002 protocol are as minimum equivalents obtained in the use of the previous ALL-MB-91 protocol. A significant improvement in the overall results of therapy and a reduction in the cumulative risk for isolated neurorecurrences were noted in the ImRG patients.
作者简介
Yu Rumyantseva
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
A Karachunsky
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
Email: aikarat@mail.ru, info@mbstudy.net
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
O Aleinikova
Republican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, BelarusRepublican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, Belarus
L Fechina
Center of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgCenter of Oncology and Hematology, Regional Children's Hospital One, Yekaterinburg
A Shamardina
Regional Children's Hospital, Nizhni NovgorodRegional Children's Hospital, Nizhni Novgorod
D Litvinov
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, Moscow
N Ponomareva
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, Moscow
E Boichenko
Children's Hospital One, Saint PetersburgChildren's Hospital One, Saint Petersburg
S Dudkin
Town Children's Hospital Four, NovokuznetskTown Children's Hospital Four, Novokuznetsk
O Streneva
Center of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgCenter of Oncology and Hematology, Regional Children's Hospital One, Yekaterinburg
K Kondratchik
Morozov City Children's Hospital, MoscowMorozov City Children's Hospital, Moscow
E Mansurova
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
L Minkina
Children's Town Hospital, VladivostokChildren's Town Hospital, Vladivostok
E Lapotentova
Republican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, BelarusRepublican Research and Practical Center of Pediatric Oncology and Hematology, Minsk, Belarus
E Inyushkina
Moscow Regional Cancer Dispensary, Balashikha, Moscow RegionMoscow Regional Cancer Dispensary, Balashikha, Moscow Region
N Yudina
Regional Children's Hospital One, VoronezhRegional Children's Hospital One, Voronezh
G Pavlova
Regional Children's Hospital, Ministry of Health and Social Development of Chuvash Republic, CheboksaryRegional Children's Hospital, Ministry of Health and Social Development of Chuvash Republic, Cheboksary
E Zhukovskaya
Regional Children's Hospital, ChelyabinskRegional Children's Hospital, Chelyabinsk
O Khlebnikova
Center of Oncology and Hematology, Regional Children's Hospital One, YekaterinburgCenter of Oncology and Hematology, Regional Children's Hospital One, Yekaterinburg
S Lagoiko
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
E Basharova
Regional Children's Hospital, ChelyabinskRegional Children's Hospital, Chelyabinsk
R Denisov
Regional Children's Hospital, ChelyabinskRegional Children's Hospital, Chelyabinsk
V Zlobina
Central District Hospital, NovosibirskCentral District Hospital, Novosibirsk
E Banshchikova
Regional Hospital One - NCM (National Center of Medicine), YakutskRegional Hospital One - NCM (National Center of Medicine), Yakutsk
K Aslanyan
Regional Children's Hospital, Rostov-on-DonRegional Children's Hospital, Rostov-on-Don
E Kondakova
Surgut District Hospital, UHMAU-Ugry, SurgutSurgut District Hospital, UHMAU-Ugry, Surgut
E Tselousova
Kirov Research Institute of Hematology and Blood TransfusionKirov Research Institute of Hematology and Blood Transfusion
N Myakova
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowRepublican Children's Hospital, Moscow
T Turobova
Regional Children's Hospital, ArkhangelskRegional Children's Hospital, Arkhangelsk
O Ryskal
Regional Children's Hospital, PermRegional Children's Hospital, Perm
N Chipsanova
Komi Republican Cardiology Dispensary, SyktyvkarKomi Republican Cardiology Dispensary, Syktyvkar
S Varfolomeyeva
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
A Rumyantsev
Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, MoscowFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow
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