Dasatinib treatment of imatinib-resistant and imatinib-intolerant patients with chronic myeloid leukemia in a chronic phase

Ol'ga Yur'evna Vinogradova; Виноградова Ольга Юрьевна; Anna Grigor'evna Turkina; Туркина Анна Григорьевна; Aleksandra Valer'evna Vorontsova; Воронцова Александра Валерьевна; Ekaterina Yur'evna Chelysheva; Челышева Екатерина Юрьевна; Galina Anatol'evna Gusarova; Гусарова Галина Анатольевна; S V Kuznetsov; Кузнецов С В; Svetlana Rudol'fovna Goryacheva; Горячева Светлана Рудольфовна; Manana Aleksandrovna Sokolova; Соколова Манана Александровна; Evgeniy Mikhaylovich Abakumov; Абакумов Евгений Михайлович; Ol'ga Veniaminovna Stakhina; Стахина Ольга Вениаминовна; Elena Vasil'evna Domracheva; Домрачева Елена Васильевна; Andrey Vital'evich Misyurin; Мисюрин Андрей Витальевич; Nina Dmitrievna Khoroshko; Хорошко Нина Дмитриевна; O Yu Vinogradova; Vinogradova O Yu; A G Turkina; Turkina A G; A V Vorontsova; Vorontsova A V; E Yu Chelysheva; Chelysheva E Yu; G A Gusarova; Gusarova G A; S V Kuznetsov; Kuznetsov S V; S R Goryacheva; Goryacheva S R; M A Sokolova; Sokolova M A; E M Abakumov; Abakumov E M; O V Stakhina; Stakhina O V; E V Domracheva; Domracheva E V; A V Misyurin; Misyurin A V; N D Khoroshko; Khoroshko N D

Dasatinib treatment of imatinib-resistant and imatinib-intolerant patients with chronic myeloid leukemia in a chronic phase

作者: Vinogradova O.¹, Turkina A.¹, Vorontsova A.¹, Chelysheva E.¹, Gusarova G.¹, Kuznetsov S¹, Goryacheva S.¹, Sokolova M.¹, Abakumov E.¹, Stakhina O.¹, Domracheva E.¹, Misyurin A.¹, Khoroshko N.¹, Vinogradova O¹, Turkina A¹, Vorontsova A¹, Chelysheva E¹, Gusarova G¹, Kuznetsov S¹, Goryacheva S¹, Sokolova M¹, Abakumov E¹, Stakhina O¹, Domracheva E¹, Misyurin A¹, Khoroshko N¹
隶属关系:
1. ГУ Гематологический научный центр РАМН
期: 卷 81, 编号 7 (2009)
页面: 41-46
栏目: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30380
ID: 30380

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Aim. To analyse resistance to imatinib therapy, efficacy and safety of dasatinib.
Material and methods. A total of 18 patients with chronic myeloid leukemia (CML) in a chronic stage received dasatinib for 9-30 months (median 30 months) to September 2008.
Results. Lethal outcomes during dasatinib treatment were absent. To September 2008, 16(89%) patients were alive, 2(11%) patients died of the disease progression after dasatinib discontinuation. A complete clinicohematological response was observed in all the patients. Major cytogenetic, complete cytogenetic, major molecular, complete molecular responses were achieved in 12(67%), 10(55%), 7(39%) and 5(28%) patients, respectively. Hematological and non-hematological toxicity occurred in 9(50%) patients. Now 12(67%) patients continue dasatinib treatment, in 6(33%) patients the drug was discontinued.
Conclusion. The results from trials in Russian Hematological Research Center are the same as in the international study. Dasatinib is effective and well tolerated therapeutic option for imatinib-resistant patients with a chronic phase of CML.

关键词

chronic myeloid leukemia, tyrosinkinase inhibitors, dasatinib, Ph-positive clone, BCR-ABL gene

参考

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Dasatinib treatment of imatinib-resistant and imatinib-intolerant patients with chronic myeloid leukemia in a chronic phase

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作者简介

Ol'ga Vinogradova

Anna Turkina

Aleksandra Vorontsova

Ekaterina Chelysheva

Galina Gusarova

S Kuznetsov

Svetlana Goryacheva

Manana Sokolova

Evgeniy Abakumov

Ol'ga Stakhina

Elena Domracheva

Andrey Misyurin

Nina Khoroshko

O Vinogradova

A Turkina

A Vorontsova

E Chelysheva

G Gusarova

S Kuznetsov

S Goryacheva

M Sokolova

E Abakumov

O Stakhina

E Domracheva

A Misyurin

N Khoroshko

参考