电邮这篇文章 Effects of recurrent herpetic infection on functional activity of T-cells in patients with rheumatoid arthritis
- 作者: Sviridova V, Kologrivova E, Pronina N, Eliseeva L, Naslednikova I, Sviridova V, Kologrivova E, Pronina N, Eliseeva L, Naslednikova I
- 期: 卷 81, 编号 6 (2009)
- 页面: 27-28
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30345
- ID: 30345
如何引用文章
全文:
详细
Material and methods. We studied in vitro production of marker cytokines of type 1 T-helpers (IL-2), type 2 T-helpers (IL-4), type 3 T-helpers TGFb and type 1 T-regulators (IL-10) and counted CD4+CD25+ T-cells in the blood of patients with recurrent herpetic infection and having no clinical manifestations of Herpes virus reactivation.
Results. Patients with recurrent herpes had more active production of IL-10, but reduced count of CD4+CD25+ lymphocytes.
Conclusion. IL-10 hyperproduction observed in recurrent herpetic infection may contribute to progression of rheumatoid arthritis.
作者简介
V Sviridova
E Kologrivova
N Pronina
L Eliseeva
I Naslednikova
V Sviridova
E Kologrivova
N Pronina
L Eliseeva
I Naslednikova
参考
- Соловьева Н. Ю., Сенникова Ю. А., Гришина Л. В., Старостина Н. М. Провоспалительные и иммунорегуляторные цитокины у больных с синдромом вторичного иммунодефицита при рецидивирующей герпетической инфекции. Мед. иммунол. 2003; 5 (5-6): 583-590.
- Lan R. Y., Aftab Ansarib A., Zhe-Xiong L., Gershwina M. E. Regulatory T cells: development, function and role in autoimmunity. Autoimmun. Rev. 2005; 4 (6): 351-363.
- Marques C. P., Hu S., Sheng W. et al. Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia 2004; 47 (4): 358-366.
- Фрейдлин И. С. Паракринные и аутокринные механизмы цитокиновой иммунорегуляции. Аллергия, астма и клин. иммунол. 2000; 8: 73-80.
- Фрейдлин И. С. Регуляторные Т-клетки: происхождение и функции. Мед. иммунол. 2005; 7 (4): 347-354.
- Bach J. F. The effect of infection on susceptibility to autoimmune and allergic diseases. N Engl. J. Med. 2002; 347: 911-920.
- Cao D., Malmstrom V., Baecher-Allan C. et al. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 2003; 33 (1): 215-223.
