电邮这篇文章 Recurrence of gastropathies caused by administration of nonsteroid anti-inflammatory drugs
- 作者: Karateev AЕ1
-
隶属关系:
- Институт ревматологии РАМН
- 期: 卷 78, 编号 5 (2003)
- 页面: 74-78
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29398
- ID: 29398
如何引用文章
全文:
详细
Aim. To estimate frequency of ulcers and erosions associated with administration of nonsteroid antiinflammatory drugs (NSAID) in patients with rheumatic diseases.
Material and methods. The analysis of the clinic endoscopic data base allowed division of the patients into three groups: group 1 -207 patients examined with esophagogastroduodenoscopy (EGDS) which detected ulcers or multiple erosions of the stomach and/or duodenum in the course of treatment with NSAID; group 2 - 157patients with a few erosions of the stomach or duodenum; group 3 - 404 controls who had neither erosions nor ulcers in the course of NSAID treatment.
Results. Frequency of detection of ulcers and multiple erosions for groups 1, 2 and 3 was 40.1, 12.1 and 7.4%, respectively. Recurrences did not correlate with age, sex, dose of glucoorticosteroids, NSAID dose, cytostatics, preventive use of antiulcer drugs. Few gastric erosions were detected more frequently in patients of group 2 than group 3 (22.9 and 9.2%, respectively, p < 0.05). Conclusion. NSAID-induced ulcers in patients with rheumatic diseases are recurrent. Preventive intake of H2-blockers did not lower the risk of ulcer recurrence. Erosions tend to recurrence but their presence do not raise the risk of ulcer development.
Material and methods. The analysis of the clinic endoscopic data base allowed division of the patients into three groups: group 1 -207 patients examined with esophagogastroduodenoscopy (EGDS) which detected ulcers or multiple erosions of the stomach and/or duodenum in the course of treatment with NSAID; group 2 - 157patients with a few erosions of the stomach or duodenum; group 3 - 404 controls who had neither erosions nor ulcers in the course of NSAID treatment.
Results. Frequency of detection of ulcers and multiple erosions for groups 1, 2 and 3 was 40.1, 12.1 and 7.4%, respectively. Recurrences did not correlate with age, sex, dose of glucoorticosteroids, NSAID dose, cytostatics, preventive use of antiulcer drugs. Few gastric erosions were detected more frequently in patients of group 2 than group 3 (22.9 and 9.2%, respectively, p < 0.05). Conclusion. NSAID-induced ulcers in patients with rheumatic diseases are recurrent. Preventive intake of H2-blockers did not lower the risk of ulcer recurrence. Erosions tend to recurrence but their presence do not raise the risk of ulcer development.
参考
- Насонов Е. Л., Каратеев А. Е. Поражения желудка, связанные с приемом нестероидных противовоспалительны препаратов. Клин. мед. 2000; 3: 4-10; 4: 4-9.
- Fries J. Non-steroidal anti-inflammatory drug safety: a vie' from the ARAM1S databank. Curr. Opin. Rheumat. I99( 9(suppl. 1): 3-7.
- Sihgh G. Gactrointestinal complications of prescription an over-the-counter nonsteroidal anti-inflammatory drug: a viei from te ARAMIS database. Am. J. Ther. 2000; 7(3): 115-121
- Ekstrom P., Carting L., Wetterhus S. et al. Prevention of pep tic ulcer and dyspeptic symptoms with omeprazole in patient receiving contiuous non-steroidal anti-inflammatory drug ther ару. A Nordic mulricentre study. Scand. J. Gastroenterol 1996; 31: 763-758.
- Hawkey С. J., Katascch J. A., Szczepanski L. et al. Omepra zole compared with misoprostol for ulcers associated with non steroidal antiinflammatory drugs. N. Engl. J. Med. 1998: 338 727-734.
- Yeomans N. D., Tulassay Z., Juharz L. et al. A comparison о omeprazole with ranitidine for ulcers associated with nonsteroidal atiinflammatory drugs. Ibid. 719-726.
- Graham D. Y. et al. Ulcer prevention in long-term users o: nonsteroidal anti-inflammatory drugs. Arch. Intern. Med 2002; 162(1): 10.
- Steen K. S. S., Lems W. F., Aertsen J. et al. Incidence of clinically manifest ulcers and their complications in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2001; 60: 443-447.
- Simon L. S. et al. Anti-inflammatory and upper gastrointestional effects of celecoxib in rheumatoid arthriris. J. A. M. A. 1999: 282(20): 1921-1928.
补充文件
