Influence of chronic obstructive pulmonary disease on hospital outcomes of percutaneous coronary interventions in patients with acute coronary syndrome
- 作者: Frolov A.1,2, Fedotov V.1,3, Frolov I.2, Pochinka I.1,2, Protasova N.2, Kouzova G.2, Mukhin A.1, Kuzmichev K.1,2
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隶属关系:
- Privolzhsky Research Medical University
- City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
- Nizhny Novgorod Scientific Research Institute of Hygiene and Occupational Diseases
- 期: 卷 96, 编号 3 (2024)
- 页面: 253-259
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/255131
- DOI: https://doi.org/10.26442/00403660.2024.03.202638
- ID: 255131
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Aim. To evaluate the impact of chronic obstructive pulmonary disease (COPD) on hospital outcomes of percutaneous coronary interventions (PCI) in patients with acute coronary syndrome (ACS).
Materials and methods. A cohort prospective study of the COPD effect on mortality and coronary microvascular obstruction (CMVO, no-reflow) development after PCI in ACS was carried out. 626 patients admitted in 2019–2020 were included, 418 (67%) – men, 208 (33%) – women. Median age – 63 [56; 70] years. Myocardial infarction with ST elevation identified in 308 patients (49%), CMVO – in 59 (9%) patients (criteria: blood flow <3 grade according to TIMI flow grade; perfusion <2 points according to Myocardial blush grade; ST segment resolution <70%). 13 (2.1%) patients died. Based on the questionnaire "Chronic Airways Diseases, A Guide for Primary Care Physicians, 2005", 2 groups of patients were identified: 197 (31%) with COPD (≥17 points) and 429 (69%) without COPD (<17 points). Groups were compared on unbalanced data (÷2 Pearson, Fisher exact test). The propensity score was calculated, and a two-way logistic regression analysis was performed. The data were balanced by the Kernel “weighting” method, logistic regression analysis was carried out using “weighting” coefficients. Results as odds ratio (OR) and 95% confidence interval.
Results. The conducted research allowed us to obtain the following results, depending on the type of analysis: 1) analysis of unbalanced data in patients with COPD: OR death 3.60 (1.16–11.12); p=0.03; OR CMVO 0.65 (0.35–1.22); p=0,18; 2) two-way analysis with propensity score: OR death 3.86 (1.09–13.74); p=0.04; OR CMVO 0.61 (0.31–1.19); p=0.15; 3) regression analysis with "weight" coefficients: OR death 12.49 (2.27–68.84); p=0.004; OR CMVO 0.63 (0.30–1.33); p=0.22.
Conclusion. The presence of COPD in patients with ACS undergoing PCI increases mortality and does not affect the incidence of CMVO.
作者简介
Alexey Frolov
Privolzhsky Research Medical University; City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: frolov-al-al@yandex.ru
ORCID iD: 0000-0001-7228-7563
канд. мед. наук, ассистент каф. госпитальной хирургии им. Б.А. Королева ФГБОУ ВО ПИМУ, врач отд-ния рентгенохирургических методов диагностики и лечения ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny Novgorod; Nizhny NovgorodVasily Fedotov
Privolzhsky Research Medical University; Nizhny Novgorod Scientific Research Institute of Hygiene and Occupational Diseases
编辑信件的主要联系方式.
Email: basil11@yandex.ru
ORCID iD: 0000-0003-4307-9321
канд. мед. наук, доц. каф. госпитальной терапии и общей врачебной практики им. В.Г. Вогралика ФГБОУ ВО ПИМУ, ст. науч. сотр. клинического отд. ФБУН ННИИГП
俄罗斯联邦, Nizhny Novgorod; Nizhny NovgorodIgor Frolov
City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: dr.iafrolov@gmail.com
ORCID iD: 0000-0003-2955-304X
врач отд-ния рентгенохирургических методов диагностики и лечения, ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny NovgorodIlya Pochinka
Privolzhsky Research Medical University; City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: pochinka4@yandex.ru
ORCID iD: 0000-0001-5709-0703
д-р мед. наук, доц., зав. каф. эндокринологии и внутренних болезней ФГБОУ ВО ПИМУ, зав. кардиологическим отд-нием ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny Novgorod; Nizhny NovgorodNatalia Protasova
City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: protasova.n1962@gmail.com
ORCID iD: 0000-0003-2099-8325
врач отд-ния рентгенохирургических методов диагностики и лечения ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny NovgorodGalina Kouzova
City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: Koyzovagalina42@gmail.com
ORCID iD: 0000-0001-5848-6216
врач отд-ния рентгенохирургических методов диагностики и лечения ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny NovgorodAleksey Mukhin
Privolzhsky Research Medical University
Email: prof.mukhin@mail.ru
ORCID iD: 0000-0003-2336-8900
д-р мед. наук, проф., зав. каф. госпитальной хирургии им. Б.А. Королева ФГБОУ ВО ПИМУ
俄罗斯联邦, Nizhny NovgorodKirill Kuzmichev
Privolzhsky Research Medical University; City Clinical Hospital No. 13 of the Nizhny Novgorod Avtozavodsky District
Email: kir2010k@yandex.ru
ORCID iD: 0000-0002-1513-0313
ассистент каф. эндокринологии и внутренних болезней ФГБОУ ВО ПИМУ, врач приемного отд-ния ГБУЗ НО «ГКБ №13 Автозаводского района г. Нижнего Новгорода»
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod参考
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