Relationship between the pain severity, use of non-steroidal anti-inflammatory drugs and blood pressure in elective large joint arthroplasty of the lower extremities
- 作者: Okisheva E.1, Mironova O.1, Berdysheva M.1, Pyatigorets E.1, Krivova N.1, Kurnosova A.1, Elizarov M.1, Smetanin S.1, Lychagin A.1, Fomin V.1
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 95, 编号 9 (2023)
- 页面: 751-756
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/254689
- DOI: https://doi.org/10.26442/00403660.2023.09.202373
- ID: 254689
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Aim. To evaluate the changes in blood pressure (BP), the severity of pain syndrome and non-steroidal anti-inflammatory drugs (NSAIDs) use patterns in patients hospitalized for elective arthroplasty of large joints of the lower extremities during the postoperative period.
Materials and methods. This study included 374 patients. In all patients, medical history, antihypertensive therapy and history of NSAIDs usage were collected, BP was measured, and the severity of pain was assessed via a 10-point scale before surgery, as well as 1 and 3 months after arthroplasty.
Results. The study included 132 (35.3%) males and 242 (64.7%) females. Among these, 289 (77.3%) patients had hypertension [grade 1 – 35 patients, grade 2 – 136 patients, grade 3 – 118 (25.0%) patients]; 280 (74.9%) patients were taking NSAIDs (121 – daily, 135 – 2–3 times per week). The median pain severity before surgery was 8 points [7; 9], 1 month after surgery – 2 points [1; 4], 3 months after surgery – 1 point [0; 3]. At 1 month after arthroplasty, 23 (7.9%) patients reported a decrease in BP. In 17 (5.9%) patients, correction of previously prescribed antihypertensive therapy with a decrease in drug doses was required. At 1 month after arthroplasty, 256 patients discontinued NSAIDs. The analysis of the relationship between the severity of pain, NSAIDs use and the level of BP revealed a significant effect of pain syndrome (p<0.0001) and the use of NSAIDs (p=0.014).
Conclusion. In the population of patients with elective arthroplasty of large joints of the lower extremities, a significant incidence of hypertension and a high prevalence of NSAIDs use are noted. During the postoperative period, a significant trend towards a decrease in the severity of pain was found, as well as the relationship of pain and NSAIDs with a decrease in BP.
作者简介
Elena Okisheva
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: e.okisheva@gmail.com
ORCID iD: 0000-0003-2977-7203
Assistant at the Department of Faculty Therapy No. 1
俄罗斯联邦, MoscowOlga Mironova
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-5820-1759
Doctor of Medical Sciences, Professor of the Department of Faculty Therapy No. 1
俄罗斯联邦, MoscowMaria Berdysheva
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-3393-6863
student
俄罗斯联邦, MoscowEvgenia Pyatigorets
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0003-2296-3900
student
俄罗斯联邦, MoscowNatalya Krivova
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0009-0002-0555-8831
student
俄罗斯联邦, MoscowAnna Kurnosova
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0009-0002-0555-9404
student
俄罗斯联邦, MoscowMikhail Elizarov
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-4811-5718
traumatologist-orthopedist Clinics of traumatology, orthopedics and joint pathology
俄罗斯联邦, MoscowSergey Smetanin
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-8607-4347
traumatologist-orthopedist Clinics of traumatology, orthopedics and joint pathology
俄罗斯联邦, MoscowAlexey Lychagin
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-2202-8149
Doctor of Medical Sciences, Professor, Head of Department. traumatology, orthopedics and disaster surgery
俄罗斯联邦, MoscowVictor Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: e.okisheva@gmail.com
ORCID iD: 0000-0002-2682-4417
member-corr. RAS, Doctor of Medical Sciences, Professor, Vice-Rector for Innovation and Clinical Activities, Head of Department. Faculty Therapy No. 1
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