Pathogenetic approaches to the correction of vascular homeostasis in patients with COVID-19: A review
- 作者: Shuldyakov A.1, Smagina A.1, Ramazanova K.1, Lyapina E.1, Chabbarov Y.1, Sheshina N.1, Zhuk A.1
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隶属关系:
- Razumovsky Saratov State Medical University
- 期: 卷 95, 编号 11 (2023)
- 页面: 1004-1008
- 栏目: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/232018
- DOI: https://doi.org/10.26442/00403660.2023.11.202487
- ID: 232018
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详细
The adverse outcomes in patients with COVID-19 in the initial phase of the disease are often due to the development of cytokine storm, endothelial dysfunction, shifts in the hemostasis system, microangiopathy, angiocentric inflammation, and pathological angiogenesis, which require targeted therapy. Unfortunately, to date, there is still no drug with proven high efficacy. This review is to analyse the literature data on the pathogenesis of vascular homeostasis lesions and possible ways to correct the existing shifts in patients with COVID-19. When the oxygen content in the tissue decreases, one of the most important mechanisms of adaptation is the activation of the succinate oxidase pathway, but under conditions of prolonged hypoxia and intoxication, the succinate reserve is rapidly depleted. That is why exogenous of succinic acid can enhance the adaptive capabilities of the organism and improve the prognosis in patients with COVID-19. Succinic acid preparations contribute to normalization of energy exchange and reduction of oxidative stress, especially in combination with inosine, nicotinamide and riboflavin and are widely used in clinical practice in various nosological forms. Taking into account the analysis of data on the mechanisms of clinical effects of succinate-containing preparations, this group of drugs can be considered as promising with regard to the correction of vascular disorders in COVID-19.
作者简介
Andrey Shuldyakov
Razumovsky Saratov State Medical University
编辑信件的主要联系方式.
Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-3009-9262
доктор медицинских наук, профессор, зав. кафедры инфекционных болезней
俄罗斯联邦, SaratovAnna Smagina
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0000-0001-5139-2188
кандидат медицинских наук, доцент кафедры инфекционных болезней
俄罗斯联邦, SaratovKristina Ramazanova
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-5249-4888
кандидат медицинских наук, доцент кафедры инфекционных болезней
俄罗斯联邦, SaratovElena Lyapina
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0000-0001-6116-0567
доктор медицинских наук, профессор кафедры инфекционных болезней
俄罗斯联邦, SaratovYusef Chabbarov
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-1872-2154
студент 6-го курса лечебного факультета
俄罗斯联邦, SaratovNatalia Sheshina
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0009-0003-2279-5430
ассистент кафедры инфекционных болезней
俄罗斯联邦, SaratovAlena Zhuk
Razumovsky Saratov State Medical University
Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-5236-0871
ординатор кафедры инфекционных болезней
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