Assessment of the possible impact of hepatitis viruses on the development and course of autoimmune liver diseases
- 作者: Sbikina E.1, Vinnitskaya E.1, Batskikh S.1, Sandler Y.1, Saliev K.1, Khaimenova T.1, Bordin D.1,2,3
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隶属关系:
- Loginov Moscow Clinical Scientific Center
- Yevdokimov Moscow State University of Medicine and Dentistry
- Tver State Medical University
- 期: 卷 95, 编号 2 (2023)
- 页面: 173-178
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/132902
- DOI: https://doi.org/10.26442/00403660.2023.02.202113
- ID: 132902
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Background. Despite the well-studied pathogenesis, the etiology of autoimmune liver disease (AILD) remains unknown.
Aim. To determine the significance of hepatitis A, B, C and E viruses in the development and progression of AILD.
Materials and methods. A single-center case-control study included 139 patients with AILD: autoimmune hepatitis – AIH (n=46), primary biliary cholangitis – PBS (n=74), primary sclerosing cholangitis – PSC (n=19). Median age 56 years, IQR 48–65 years. 125 patients – without liver disease – control group (median age 55 years, IQR 46–65 years). Testing of blood serum samples for anti-HAV IgG, anti-HEV IgG, HBsAg, anti-HBc IgG, anti-HCV was carried out by solid-phase ELISA. All patients underwent fibroelastography. Needle liver biopsy – 70 patients: AIH (n=37), PBC (n=28) and PSC (n=5).
Results. Ab(IgG) to HAV and HBV were detected in patients with AILD significantly more often than in the control group (74.8% vs 54.4%; p<0.001). An increased risk of developing AILD was established in patients with the presence of antibodies to HAV, HBV and HEV (OR 2.491, CI 95% [1.481–4.190]). The highest risk of developing PBC was found in patients with antibodies to HAV and HBV (OR 3.008, 95% CI [1.633–5.542] and OR 2.515, 95% CI [1.242–5.093]). In patients with severe liver fibrosis (F3–F4 according to METAVIR), antibodies to HAV and HBV were detected significantly more often than in patients with F0–F2 [85% vs 65%; p=0.008].
Conclusion. In our work, we have demonstrated the relationship of past hepatitis A, B, E and AILD, as well as the high risk of developing severe fibrosis in patients with AILD and markers of hepatitis A and B viruses indicates the possible involvement of these viruses in the pathogenesis of AILD.
作者简介
Evgeniya Sbikina
Loginov Moscow Clinical Scientific Center
编辑信件的主要联系方式.
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0003-2195-9643
мл. науч. сотр. отд. гепатологии
俄罗斯联邦, MoscowElena Vinnitskaya
Loginov Moscow Clinical Scientific Center
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0002-0344-8375
д-р мед. наук, зав. отд. гепатологии
俄罗斯联邦, MoscowSergey Batskikh
Loginov Moscow Clinical Scientific Center
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0002-5917-203X
канд. мед. наук, ст. науч. сотр. отд. гепатологии
俄罗斯联邦, MoscowYuliay Sandler
Loginov Moscow Clinical Scientific Center
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0003-4291-812X
канд. мед. наук, ст. науч. сотр. отд. гепатологии
俄罗斯联邦, MoscowKirill Saliev
Loginov Moscow Clinical Scientific Center
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0002-4581-7052
мл. науч. сотр. отд. гепатологии
俄罗斯联邦, MoscowTatyana Khaimenova
Loginov Moscow Clinical Scientific Center
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0002-4599-4040
канд. мед. наук, зав. отд-нием хронических заболеваний печени
俄罗斯联邦, MoscowDmitry Bordin
Loginov Moscow Clinical Scientific Center; Yevdokimov Moscow State University of Medicine and Dentistry; Tver State Medical University
Email: e.sbikina@mknc.ru
ORCID iD: 0000-0003-2815-3992
д-р мед. наук, зав. отд. патологии поджелудочной железы, желчных путей и верхних отделов пищеварительного тракта, проф. каф. пропедевтики внутренних болезней и гастроэнтерологии, проф. каф. общей врачебной практики и семейной медицины
俄罗斯联邦, Moscow; Moscow; Tver参考
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