Levilimab and baricitinib prescribing experience in outpatient COVID-19 patients’ treatment
- 作者: Khripun A.1, Starshinin A.1, Antipova Y.1, Lysenko M.2,3, Urozhaeva Y.4, Gavrilenko O.5, Rusantsova N.5, Tyazhelnikov A.1,6, Tikhonovskaya E.7, Okolot N.8, Sokolova M.9, Fomina D.2,10, Simonova E.2, Kruglova T.2, Chernov A.2,11, Zagrebneva A.2,3
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隶属关系:
- Department of Health
- City Clinical Hospital №52
- Pirogov Russian National Research Medical University
- Main Control Department
- Medical Inspection Center
- Consultative and Diagnostic Polyclinic №121
- City Polyclinic №36
- City Polyclinic №166
- City Polyclinic №191
- Sechenov First Moscow State Medical University (Sechenov University)
- Russian Medical Academy of Continuous Professional Education
- 期: 卷 94, 编号 5 (2022)
- 页面: 668-674
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/108789
- DOI: https://doi.org/10.26442/00403660.2022.05.201676
- ID: 108789
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Aim. To study the effect of levilimab or baricitinib in combination with standard therapy (ST) on the incidence of severe viral pneumonia associated with a new coronavirus infection COVID-19.
Materials and methods. A multicenter, open-label observational study of the efficacy and safety of levilimab in combination with ST (group 1, n=100), baricitinib in combination with ST (group 2, n=139), or in comparison with ST (group 3, n=200) in outpatients with verified CT-1 pneumonia.
Results. According to the results of laboratory tests, patients treated with levilimab in combination with ST had the best dynamics of changes in CRP from reliably the highest level (mg/L) to the lowest in comparison with other groups. In the group of patients with ST, in contrast to the other groups, no dynamics of CRP was observed by day 5 of therapy. In group of hospitalized patients initially receiving levilimab in addition to ST, the rate of transfer to the intensive care unit (2 patients, 9.52%) and length of stay (4 days) was significantly lower compared to the values in patients in both the baricitinib group in combination with ST (7 patients, 15.56%; 5 days [interquartile range 3–6.5]) and in patients receiving ST alone (7 patients, 15.56%; 5 days [interquartile range 3–6.5]). Also in hospitalized patients we observed no statistically significant intergroup differences in the incidence of infectious complications and thromboembolic events, which confirms the safety of including levilimab or baricitinib in COVID-19 pathogenetic therapy regimens. Observational results support the hypothesis that the initial inclusion of levilimab or baricitinib in addition to ST is accompanied by a reduced risk of viral pneumonia progression.
Conclusion. The addition of levilimab or baricitinib to the therapy regimen for coronavirus infection during the outpatient phase has demonstrated a preemptive anti-inflammatory effect and reduced the probability of lung tissue damage progression.
作者简介
Alexey Khripun
Department of Health
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-2929-1142
д-р мед. наук, проф., министр правительства Москвы, рук. ДЗМ
俄罗斯联邦, MoscowAndrey Starshinin
Department of Health
Email: alrheumo@mail.ru
ORCID iD: 0000-0003-3565-2124
канд. мед. наук, зам. рук. ДЗМ
俄罗斯联邦, MoscowYulia Antipova
Department of Health
Email: alrheumo@mail.ru
зам. рук. ДЗМ
俄罗斯联邦, MoscowMariana Lysenko
City Clinical Hospital №52; Pirogov Russian National Research Medical University
Email: alrheumo@mail.ru
ORCID iD: 0000-0001-6010-7975
д-р мед. наук, глав. врач ГБУЗ ГКБ №52, проф. каф. общей терапии фак-та дополнительного профессионального образования ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»
俄罗斯联邦, Moscow; MoscowYulia Urozhaeva
Main Control Department
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-0378-0642
зам. нач. Главного контрольного управления г. Москвы
俄罗斯联邦, MoscowOlga Gavrilenko
Medical Inspection Center
Email: alrheumo@mail.ru
ORCID iD: 0000-0003-1765-9373
зам. дир. по контролю за текущей деятельностью и работе с обращениями граждан ГКУЗ ЦМИ
俄罗斯联邦, MoscowNatalya Rusantsova
Medical Inspection Center
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-4947-0308
зав. организационно-методическим отд. обеспечения ведомственного контроля качества и безопасности медицинской деятельности ГКУЗ ЦМИ
俄罗斯联邦, MoscowAndrei Tyazhelnikov
Department of Health; Consultative and Diagnostic Polyclinic №121
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-2191-0623
канд. мед. наук, глав. внештат. специалист по первичной медико-санитарной помощи взрослому населению ДЗМ, глав. врач ГБУЗ КДП №121
俄罗斯联邦, Moscow; MoscowElena Tikhonovskaya
City Polyclinic №36
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-1295-5096
канд. мед. наук, глав. врач ГБУЗ ГП №36
俄罗斯联邦, MoscowNatalia Okolot
City Polyclinic №166
Email: alrheumo@mail.ru
ORCID iD: 0000-0001-5159-3959
глав. врач ГБУЗ ГП №166
俄罗斯联邦, MoscowMaria Sokolova
City Polyclinic №191
Email: alrheumo@mail.ru
ORCID iD: 0000-0001-9495-0071
канд. мед. наук, глав. врач ГБУЗ ГП №191
俄罗斯联邦, MoscowDaria Fomina
City Clinical Hospital №52; Sechenov First Moscow State Medical University (Sechenov University)
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-5083-6637
канд. мед. доц., наук, врач аллерголог-иммунолог, рук. Московского городского научно-практического центра аллергологии и иммунологии ГБУЗ ГКБ №52, доц. каф. клинической иммунологии и аллергологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
俄罗斯联邦, Moscow; MoscowElena Simonova
City Clinical Hospital №52
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-8372-6995
врач-ревматолог консультативно-диагностического отд. №2 ГБУЗ ГКБ №52
俄罗斯联邦, MoscowTatiana Kruglova
City Clinical Hospital №52
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-4949-9178
врач аллерголог-иммунолог, зав. отд-нием аллергологии и иммунологии ГБУЗ ГКБ №52
俄罗斯联邦, MoscowAnton Chernov
City Clinical Hospital №52; Russian Medical Academy of Continuous Professional Education
Email: alrheumo@mail.ru
ORCID iD: 0000-0001-6209-387X
врач-терапевт отд. клинической фармакологии ГБУЗ ГКБ №52, мл. науч. сотр. Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
俄罗斯联邦, Moscow; MoscowAlena Zagrebneva
City Clinical Hospital №52; Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: alrheumo@mail.ru
ORCID iD: 0000-0002-3235-1425
канд. мед. наук, зав. консультативно-диагностическим отд-нием №2 ГБУЗ ГКБ №52, доц. каф. общей терапии фак-та дополнительного профессионального образования ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»
俄罗斯联邦, Moscow; Moscow参考
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