The role of the angiotensins in the pathogenesis of inflammatory joint disease
- Authors: Gordeev A.V.1, Galushko E.A.1, Savushkina N.M.1
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Affiliations:
- Nasonova Research Institute of Rheumatology
- Issue: Vol 93, No 5 (2021)
- Pages: 635-639
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/71521
- DOI: https://doi.org/10.26442/00403660.2021.05.200796
- ID: 71521
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Abstract
The significant humoral effect of the renin-angiotensin-aldosterone system on the regulation of the cardiovascular system and blood pressure has long been widely known. However, the identification and interpretation of new components of renin-angiotensin-aldosterone system in recent years can significantly expand the range of its potential effects on the body. The anti-inflammatory effect of drugs that block angiotensin II and its receptors, including in rheumatic diseases, can become practically significant for General therapists by their effect on reducing the concentration of inflammatory mediators and angiogenesis processes. The organoprotective and anti-inflammatory potentials of drugs that reduce the production of at demonstrated in vitro and in vivo experiments allow us to consider them as first-line angiotropic agents in patients with rheumatoid arthritis, especially in the presence of pathology of the cardiovascular system and kidneys.
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##article.viewOnOriginalSite##About the authors
Andrei V. Gordeev
Nasonova Research Institute of Rheumatology
Email: egalushko@mail.ru
ORCID iD: 0000-0001-9820-8851
д-р мед. наук, зав. лаб. ранних артритов
Russian Federation, MoscowElena A. Galushko
Nasonova Research Institute of Rheumatology
Author for correspondence.
Email: egalushko@mail.ru
ORCID iD: 0000-0002-2776-4276
д-р мед. наук, вед. науч. сотр. лаб. ранних артритов
Russian Federation, MoscowNatalia M. Savushkina
Nasonova Research Institute of Rheumatology
Email: egalushko@mail.ru
ORCID iD: 0000-0001-8562-6077
канд. мед. наук, науч. сотр. лаб. ранних артритов
Russian Federation, MoscowReferences
- Насонов Е.Л., Лила А.М., Галушко Е.А., и др. Стратегия развития ревматологии: от научных достижений к практическому здравоохранению. Научно-практическая ревматология. 2017;55(4):339-43 [Nasonov ЕL, Lila AM, Galushko ЕA, et al. Rheumatology development strategy: from scientific achievements to practical health care. Rheumatology Science and Practice. 2017;55(4):339-43 (in Russian)]. doi: 10.14412/1995-4484-2017-339-343
- Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023-38. doi: 10.1016/S0140-6736(16)30173-8
- McInnes IB, Schett G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet. 2017;389:2328-37. doi: 10.1016/S0140-6736(17)31472-1
- Насонов Е.Л., Попкова Т.В. Противовоспалительная терапия атеросклероза – вклад и уроки ревматологии. Научно-практическая ревматология. 2017;55(5):465-73 [Nasonov EL, Popkova TV. Anti-inflammatory therapy for atherosclerosis: contribution to and lessons of rheumatology. Rheumatology Science and Practice. 2017;55(5):465-73 (in Russian)]. doi: 10.14412/1995-4484-2017-465-473
- Вайсман Д.Ш., Сороцкая В.Н., Никитина Е.С. Анализ смертности от болезней костно-мышечной системы по первоначальной и множественным причинам у жителей Тульской области. Научно-практическая ревматология. 2017;55(6):616-20 [Vaysman DSh, Sorotskaya VN, Nikitina ES. Analysis of mortality from diseases of the musculoskeletal system for the initial and multiple causes in the inhabitants of the Tula region. Rheumatology Science and Practice. 2017;55(6):616-20 (in Russian)]. doi: 10.14412/1995-4484-2017-616-620
- Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73(1):62-8. doi: 10.1136/annrheumdis-2013-204223
- Choi IA, Park SH, Cha HS. Prevalence of co-morbidities and evaluation of their monitoring in Korean patients with rheumatoid arthritis: comparison with the results of an international, cross-sectional study (COMORA). Int J Rheum Dis. 2018;21(7):1414-22. doi: 10.1111/1756-185X.13013
- Гордеев А.В., Галушко Е.А., Савушкина Н.М., и др. Оценка мультиморбидного профиля (CIRS) при ревматоидном артрите. Первые результаты. Современная ревматология. 2019;13(3):10-6 [Gordeev AV, Galushko EA, Savushkina NM, et al. Assessing the multimorbid profile (CIRS) in rheumatoid arthritis. First results. Modern Rheumatology Journal. 2019;13(3):10-6 (in Russian)]. doi: 10.14412/1996-7012-2019-3-10-16
- Meune C, Touze E, Trinquart L, et al. High risk of clinical cardiovascular events in RA: levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. Arch Cardiovasc Dis. 2010;103:253-61. doi: 10.1016/j.acvd.2010.03.007
- Сороцкая В.Н., Никитина Е.С., Плахова А.О., и др. Анализ по первоначальной и множественным причинам смерти при ревматоидном артрите у жителей Тульской области. Научно-практическая ревматология. 2017;55(S2-1):120 [Sorockaya VN, Nikitina ES, Plahova AO, et al. Analysis of the initial and multiple causes of death in rheumatoid arthritis in residents of the Tula region. Rheumatology Science and Practice. 2017;55(S2-1):120 (in Russian)].
- Мутовина З.Ю., Загребнева А.И., Галушко Е.А., Гордеев А.В. Кардиоренальный синдром у больных ревматоидным артритом. Современная ревматология. 2019;13(3):82-6 [Mutovina ZYu, Zagrebneva AI, Galushko EA, Gordeev AV. Cardiorenal syndrome in patients with rheumatoid arthritis. Modern Rheumatology Journal. 2019;13(3):82-6. (in Russian)]. doi: 10.14412/1996-7012-2019-3-82-86
- Насонов Е.Л., Гордеев А.В., Галушко Е.А. Ревматические заболевания и мультиморбидность. Терапевтический архив. 2015;87(5):4-9 [Nasonov EL, Gordeev AV, Galushko EA. Rheumatic diseases and multimorbidity. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(5):4-9 (in Russian)]. doi: 10.17116/terarkh20158754-9
- Насонов Е.Л., Лила А.М. Ингибиторы Янус-киназ при иммуновоспалительных ревматических заболеваниях: новые возможности и перспективы. Научно-практическая ревматология. 2019;57(1): 8-16 [Nasonov EL, Lila AM. Janus kinase inhibitors in immuno-inflammatory rheumatic diseases: new opportunities and prospects. Rheumatology Science and Practice. 2019;57(1):8-16 (in Russian)]. doi: 10.14412/1995-4484-2019-8-16
- Morgan L, Broughton PF, Kalsheker N. Angiotensinogen: molecular biology, biochemistry and physiology. Int J Biochem Cell Biol. 1996;28:1211-22. doi: 10.1016/s1357-2725(96)00086-6
- Dzau V, Braunwald E. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement. Am Heart J. 1991;121(4 Pt. 1):1244-63. doi: 10.1016/0002-8703(91)90694-d
- Wagner M, Tiffe T, Morbach C, еt al. STAAB-Consortium. Characteristics and Course of Heart Failure Stages A – B and Determinants of Progression – design and rationale of the STAAB cohort study. Eur J Prev Cardiol. 2017;24(5):468-79. doi: 10.1177/2047487316680693
- Bader M. Tissue renin-angiotensin-aldosterone systems: targets for opharmacological therapy. Ann Rev Pharmacol Toxicol. 2010;50:439-65. doi: 10.1146/annurev.pharmtox.010909.105610
- Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci. 2008;29:367-74. doi: 10.1016/j.tips.2008.05.003
- Williams B, Baker AQ, Gallacher B, et al. Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells. Hypertension. 1995;25:913-7. doi: 10.1161/01.HYP.25.5.913
- Nobuhiko A, Suganuma E, Babaev VR, et al. Angiotensin II amplifies macrophage-driven atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:2143-8. doi: 10.1161/01.ATV.0000145607.03879.e0
- Han C, Liu J, Liu X, Li M. Angiotension II induces C-reactive protein expression Accepted through ERK1/2 and JNK signaling in human aortic cells. Atherosclerosis. 2010;212:206-12. doi: 10.1016/j.atherosclerosis.2010.05.020
- Насонов Е.Л. Коронавирусная болезнь 2019 (COVID-19): размышления ревматолога. Научно-практическая ревматология. 2020;58(2):123-32 [Nasonov EL. Coronavirus disease 2019 (COVID-19): A rheumatologist’s thoughts. Rheumatology Science and Practice. 2020;58(2):123-32 (in Russian)]. doi: 10.14412/1995-4484-2020-123-132
- Jarcho JA, Ingelfinger JR, Hamel MB. Inhibitors of the Renin-Angiotensin-Aldosterone System and Covid-19. New Engl J Med. 2020;4(5):1-3. doi: 10.1056/NEJMoa2008975
- Silveira KD, Coelho FM, Vieira AT, et al. Mechanisms of the antiinflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis. Peptides. 2013;46:53-63. doi: 10.1016/j.peptides.2013.05.012
- Refaat R, Salama M, Abdel Meguid E, et al. Evaluation of the effect of losartan and methotrexate combined therapy in adjuvantinduced arthritis in rats. Eur J Pharmacol. 2013;698(13):421-8. doi: 10.1016/j.ejphar.2012.10.024
- Wang D, Hu S, Zhu J, et al. Angiotensin II type 2 receptor correlates with therapeutic effects of losartan in rats with adjuvantinduced arthritis. J Cell Mol Med. 2013;17(12):1577-87. doi: 10.1111/jcmm.12128
- Dalbeth N, Edwards J, Fairchild S, et al. The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford). 2005;44(1):2431. doi: 10.1093/rheumatology/keh398
- Sagawa K, Nagatani K, Komagata Y, et al. Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in mice. Arthritis Rheum. 2005;52(6):1920-8. doi: 10.1002/art.21040
- Sakuta T, Morita Y, Satoh M, et al. Involvement of the reninangiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers. Arthritis Rheum. 2010;62(5):1319-28. doi: 10.1002/art.27384
- Schroeder M, Viezens L, Fuhrhop I, et al. Angiogenic growth factors in rheumatoid arthritis. Rheumatol Int. 2013;33(2):523-7. doi: 10.1007/s00296-011-2210-6
- Марченко Ж.С., Лукина Г.В. Роль сосудистого эндотелиального фактора роста в патогенезе ревматоидного артрита. Научно-практическая ревматология. 2005;43(1):5760 [Marchenko ZhS, Lukina GV. Role of vascular endothelial growth factor in pathogenesis of rheumatoid arthritis. Rheumatology Science and Practice. 2005;43(1):57-60 (in Russian)]. doi: 10.14412/1995-44842005-558
- Vreju F, Ciurea M, Rosu A, et al. Power Doppler sonography, a non-invasive method of assessment of the synovial inflammation in patients with early rheumatoid arthritis. Rom J Morphol Embryol. 2011;52(2):637-43
- Насонов Е.Л. Проблемы иммунопатологии ревматоидного артрита: эволюция болезни. Научно-практическая ревматология. 2017;55(3):277-94 [Nasonov EL. Problems of rheumatoid arthritis immunopathology: evolution of the disease. Rheumatology Science and Practice. 2017;55(3):277-94 (in Russian)]. doi: 10.14412/1995-4484-2017-277-294
- Napoleone E, Cutrone A, Cugino D, et al. Inhibition of the reninangiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells. Thromb Res. 2012;129(6):736-42. doi: 10.1016/j.thromres.2011.11.047
- Kim S, Toyokawa H, Yamao J, et al. Antitumor effect of angiotensin II type 1 receptor blocker losartan for orthotopic rat pancreatic adenocarcinoma. Pancreas. 2014;43(6):886-90. doi: 10.1097/MPA.0000000000000125
- Park YA, Choi CH, Do IG, et al. Dual targeting of angiotensin receptors (AGTR1 and AGTR2) in epithelial ovarian carcinoma. Gynecol Oncol. 2014;135(1):108-17. doi: 10.1016/j.ygyno.2014.06.031
- Kawakami Y, Matsuo K, Murata M, et al. Expression of angiotensin II receptor-1 in human articular chondrocytes. Arthritis. 2012;2012:648537. doi: 10.1155/2012/648537
- Goto M, Sasano M, Fuzisawa M, et al. Constitutive production of angiotensin converting enzyme from rheumatoid nodule cells under serum free conditions. Ann Rheum Dis. 1992;51(6):7412. doi: 10.1136/ard.51.6.741
- Veale D, Yanni G, Bresnihan B, et al. Production of angiotensin converting enzyme by rheumatoid synovial membrane. Ann Rheum Dis. 1992;51(4):476-80. doi: 10.1136/ard.51.4.476
- Da Silveira KD, Coelho FM, Vieira AT, et al. Anti-inflammatory effects of the activation of the angiotensin-(1–7) receptor, MAS, in experimental models of arthritis. J Immunol. 2010;185(9):5569-76. doi: 10.4049/jimmunol.1000314
- Mori J, Patel VB, Ramprasath T, et al. Angiotensin 1–7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation and lipotoxicity. Am J Physiol Renal Physiol. 2014;306(8):812-21. doi: 10.1152/ajprenal.00655.2013
- Gounder VK, Arumugam S, Arozal W, et al. Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats. Int Immunopharmacol. 2014;18(2):282-9. doi: 10.1016/j.intimp.2013.11.018.