The role of the angiotensins in the pathogenesis of inflammatory joint disease

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Abstract

The significant humoral effect of the renin-angiotensin-aldosterone system on the regulation of the cardiovascular system and blood pressure has long been widely known. However, the identification and interpretation of new components of renin-angiotensin-aldosterone system in recent years can significantly expand the range of its potential effects on the body. The anti-inflammatory effect of drugs that block angiotensin II and its receptors, including in rheumatic diseases, can become practically significant for General therapists by their effect on reducing the concentration of inflammatory mediators and angiogenesis processes. The organoprotective and anti-inflammatory potentials of drugs that reduce the production of at demonstrated in vitro and in vivo experiments allow us to consider them as first-line angiotropic agents in patients with rheumatoid arthritis, especially in the presence of pathology of the cardiovascular system and kidneys.

About the authors

Andrei V. Gordeev

Nasonova Research Institute of Rheumatology

Email: egalushko@mail.ru
ORCID iD: 0000-0001-9820-8851

д-р мед. наук, зав. лаб. ранних артритов

Russian Federation, Moscow

Elena A. Galushko

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: egalushko@mail.ru
ORCID iD: 0000-0002-2776-4276

д-р мед. наук, вед. науч. сотр. лаб. ранних артритов

Russian Federation, Moscow

Natalia M. Savushkina

Nasonova Research Institute of Rheumatology

Email: egalushko@mail.ru
ORCID iD: 0000-0001-8562-6077

канд. мед. наук, науч. сотр. лаб. ранних артритов

Russian Federation, Moscow

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2. Fig. 1. Functioning cascading reactions of renin-angiotensin-aldosterone system.

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