Modern approaches to the detection of monoclonal gammopathy of undetermined significance (MGUS) in patients with kidney diseases
- Authors: Kozlovskaya(Lysenko) L.V1, Chebotareva N.V1, Mrykhin N.N1, Rameev V.V1, Androsova T.V1, Roshchupkina S.V1, Maryina S.A2, Kogarko I.N3, Kogarko B.S3
-
Affiliations:
- Sechenov First Moscow State Medical University of the Ministry (Sechenov University)
- National Research Center for Hematology of the Ministry of Health of the Russian Federation
- Semenov Institute of Chemical Physics of the Russian Academy of Sciences
- Issue: Vol 91, No 6 (2019)
- Pages: 67-72
- Section: Articles
- URL: https://journals.rcsi.science/0040-3660/article/view/59003
- DOI: https://doi.org/10.26442/00403660.2019.06.000281
- ID: 59003
Cite item
Full Text
Abstract
Full Text
##article.viewOnOriginalSite##About the authors
L. V Kozlovskaya(Lysenko)
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia
N. V Chebotareva
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)
Email: natasha_tcheb@mail.ru
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; тел.: +7(905)543-42-50; e-mail: natashatcheb@mail.ru; ORCID: 0000-0003-2128-8560 Moscow, Russia
N. N Mrykhin
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)врач клинической лабораторной диагностики, кабинет лабораторных исследований Университетской клинической больницы №3 ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia
V. V Rameev
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia
T. V Androsova
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)к.м.н., ассистент каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia
S. V Roshchupkina
Sechenov First Moscow State Medical University of the Ministry (Sechenov University)зав. отд-нием нефрологии клиники нефрологии, внутренних болезней и ревматологии Университетской клинической больницы №3 ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia
S. A Maryina
National Research Center for Hematology of the Ministry of Health of the Russian Federationруководитель группы гуморального иммунитета ФГБУ «НМИЦ гематологии» Moscow, Russia
I. N Kogarko
Semenov Institute of Chemical Physics of the Russian Academy of Sciencesд.м.н., в.н.с. отд. динамики химических и биологических процессов ФГБУН «Институт химической физики им. Н.Н. Семенова» Moscow, Russia
B. S Kogarko
Semenov Institute of Chemical Physics of the Russian Academy of Sciencesд.м.н., в.н.с. отд. динамики химических и биологических процессов ФГБУН «Институт химической физики им. Н.Н. Семенова» Moscow, Russia
References
- Leung N, Bridoux F, Hutchison C.A, Nasr S.H, Cockwell P, Fermand J.P, Dispenzieri A, Song K.W, Kyle R.A; International Kidney and Monoclonal Gammopathy Research Group. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012;120(22):4292-5. doi: 10.1182/ blood-2012-07-445304
- Parry H, Pratt G, Hutchison C. Monoclonal gammopathy of undetermined significance: an update for nephrologists. Adv Chron Kidney Dis. 2012;19(5):291-6. doi: 10.1053/j.ackd.2012.07.006
- Nasr S.H, Satoskar A, Markowitz G.S, Valeri A.M, Appel G.B, Stokes M.B, Nadasdy T, D'Agati V.D. Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol. 2009;20:2055-64. doi: 10.1681/ASN.2009010110
- Bridoux F, Leung N, Hutchison C.A, Touchard G, Sethi S, Fermand J.P, Picken M.M, Herrera G.A, Kastritis E, Merlini G, Roussel M, Fervenza F.C, Dispenzieri A, Kyle R.A, Nasr S.H; International Kidney and Monoclonal Gammopathy Research Group. Diagnosis of monoclonal gammopathy of renal significance. Kidney Int. 2015;87(4):698-711. doi: 10.1038/ki.2014.408
- Hogan J.J, Weiss B.M. Bridging the divide: an onco - nephrologic approach to the monoclonal gammopathies of renal significance. Clin J Am Soc Nephrol. 2016;11(9):1681-91. doi: 10.2215/CJN.03160316
- Chauvet S, Frémeaux-Bacchi V, Petitprez F, Karras A, Daniel L, Burtey S, Choukroun G, Delmas Y, Guerrot D, François A, Le Quintrec M, Javaugue V, Ribes D, Vrigneaud L, Arnulf B, Goujon J.M, Ronco P, Touchard G, Bridoux F. Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy - associated C3 glomerulopathy. Blood. 2017;129(11):1437-47. doi: 10.1182/blood-2016-08-737163
- Willrich M.A.V, Murray D.L, Kyle R.A. Laboratory testing for monoclonal gammopathies: Focus on monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Clin Biochem. 2018;51:38-47. doi: 10.1016/j.clinbiochem.2017.05.001
- Katzmann J.A, Kyle R.A, Benson J, Larson D.R, Snyder M.R, Lust J.A, Rajkumar S.V, Dispenzieri A. Screening panels for detection of monoclonal gammopathies. Clin Chem. 2009;55(8):1517-22. doi: 10.1373/clinchem.2009.126664
- Dispenzieri A, Kyle R, Merlini G, Miguel J.S, Ludwig H, Hajek R, Palumbo A, Jagannath S, Blade J, Lonial S, Dimopoulos M, Comenzo R, Einsele H, Barlogie B, Anderson K, Gertz M, Harousseau J.L, Attal M, Tosi P, Sonneveld P, Boccadoro M, Morgan G, Richardson P, Sezer O, Mateos M.V, Cavo M, Joshua D, Turesson I, Chen W, Shimizu K, Powles R, Rajkumar S.V, Durie B.G; International Myeloma Working Group. International Myeloma Working Group guidelines for serum - free light chain analysis in multiple myeloma and related disorders. Leukemia. 209;23:215-24. doi: 10.1038/leu.2008.307
- Dimopoulos M, Kyle R, Fermand J.P, Rajkumar S.V, San Miguel J, Chanan-Khan A, Ludwig H, Joshua D, Mehta J, Gertz M, Avet-Loiseau H, Beksaç M, Anderson K.C, Moreau P, Singhal S, Goldschmidt H, Boccadoro M, Kumar S, Giralt S, Munshi N.C, Jagannath S; International Myeloma Workshop Consensus Panel 3. Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3. Blood. 2011;117(18):4701-5. doi: 10.1182/blood-2010-10-299529
- Hill P.G, Forsyth J.M, Rai B, Mayne S. Serum free light chains: an alternative test to urine Bence Jones proteins when screening for monoclonal gammopathies. Clin Chem. 2006;52:1743-8. doi: 10.1373/clinchem.2006.069104
- Jenner E. Serum free light chains in clinical laboratory diagnostics. Clin Chim Acta. 2014;427:15-20. doi: 10.1016/j.cca.2013.08.018
- Palladini G, Russo P, Bosoni T, Verga L, Sarais G, Lavatelli F, Nuvolone M, Obici L, Casarini S, Donadei S, Albertini R, Righetti G, Marini M, Graziani M.S, Melzi D'Eril G.V, Moratti R, Merlini G. Identification of amyloidogenic light chains requires the combination of serum - free light chain assay with immunofixation of serum and urine. Clin Chem. 2009;55(3):499-504. doi: 10.1373/clinchem.2008.117143
- Katzmann J.A, Dispenzieri A, Kyle R.A, Snyder M.R, Plevak M.F, Larson D.R, Abraham R.S, Lust J.A, Melton L.J 3rd, Rajkumar S.V. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc. 2006;81(12):1575-8. doi: 10.4065/81.12.1575
- Hutchison C, Basnayake K, Cockwell P. Serum free light chain assessment in monoclonal gammopathy and kidney disease. Nat Rev Nephrol. 2009;5:621-7. doi: 10.1038/nrneph.2009.151
- Katzmann J.A, Clark R.J, Abraham R.S, Bryant S, Lymp J.F, Bradwell A.R, Kyle R.A. Serum reference intervals and diagnostic ranges for free and free immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002;48(9):1437-44. PMID: 12194920
- Dispenzieri A, Katzmann J.A, Kyle R.A, Larson D.R, Melton L.J 3rd, Colby C.L, Therneau T.M, Clark R, Kumar S.K, Bradwell A, Fonseca R, Jelinek D.F, Rajkumar S.V. Prevalence and risk of progression of light - chain monoclonal gammopathy of undetermined significance: A retrospective population - based cohort study. Lancet. 2010;375:1721-8. doi: 10.1016/S0140-6736(10)60482-5
- Keeling J, Herrera G.A. Matrix metalloproteinases and mesangial remodeling in light chain - related glomerular damage. Kidney Int. 2005;68(4):1590-603. doi: 10.1111/j.1523-1755.2005.00571.x
- Basnayake K, Stringer S, Hutchison C, Cockwell P. The biology of immunoglobulin free light chains and kidney injury. Kidney Int. 2011;79:1289-301. doi: 10.1038/ki.2011
- Kapoulas S, Raptis V, Papaioannou M. New aspects on the pathogenesis of renal disorders related to monoclonal gammopathies. Nephrol Ther. 2015;11(3):135-43. doi: 10.1016/j.nephro.2014.12.005
- Zhu L, Herrera G.A, Murphy-Ullrich J.E, Huang Z.Q, Sanders P.W. Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor - beta. Am J Pathol. 1995;147(2):375-85.
- Russell W.J, Cardelli J, Harris E, Baier R.J, Herrera G.A. Monoclonal light chain - mesangial cell interactions: early signaling events and subsequent pathologic effects. Lab Invest. 2001;81:689-703.
- Teng J, Russell W.J, Gu X, Cardelli J, Jones M.L, Herrera G.A. Different types of glomerulopathic light chains interact with mesangial cells using a common receptor but exhibit different intracellular trafficking patterns. Lab Invest. 2004;84(4):440-51. doi: 10.1038/labinvest.3700069
- Keeling J, Teng J, Herrera G.A. AL-amyloidosis and light - chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. Lab Invest. 2004;84(10):1322-38.
- Meri S, Koistinen V, Miettinen A, Tornroth T.G, Seppala I.J.T. Activation of the alternative pathaway of complement by monoclonal lambda L chains in membranoproliferative glomerulonephritis. J Exp Med. 1992;175:939-50.
- Jokiranta T.S, Solomon A, Pangburn M.K, Zipfel P.F, Meri S. Nephritogenic lambda light chain dimer: a unique human miniautoantibody against factor H. J Immunol. 1999;163:4590-6.
- Knight G.B, Gao L, Gragnani L, Elfahal M.M, De Rosa F.G, Gordon F.D, Agnello V. Detection of WA B cells in hepatitis C virus infection: a potential prognostic marker for cryo - globulinemic vasculitis and B cell malignancies. Arthritis Rheum. 2010;62:2152-9. doi: 10.1002/art.27490
- Wang P.X, Sanders P.W. Immunoglobulin light chains generate hydrogen peroxide. J Am Soc Nephrol. 2007;18(4):1239-45. doi: 10.1681/ASN.2006111299
- Sethi S, Fervenza F.C, Rajkumar S.V. Spectrum of manifestations of monoclonal gammopathy - associated renal lesions. Curr Opin Nephrol Hypertens. 2016;25:127-37. doi: 10.1097/MNH.0000000000000201
- Zakharova E.V, Stolyarevich E.S, Vorobyeva O.A, Nikitin E.A Combined immunoglobulin G kappa nephropathy: Monoclonal immunoglobulin deposition disease and proximal tubulopathy: monoclonal gammopathy of renal significance or smoldering multiple myeloma? Case report and review of literature. Integr Cancer Sci Therap. 2017;4(1):1-9. doi: 10.15761/ICST.1000225