Dilated cardiomyopathy as a clinical syndrome: experience with nosological diagnosis with biopsy and treatment approaches

Ol'ga Vladimirovna Blagova; Благова Ольга Владимировна; A V Nedostup; Недоступ А В; E A Kogan; Коган Е А; S L Dzemeshkevich; Дземешкевич С Л; Yu V Frolova; Фролова Ю В; V P Sedov; Седов В П; N V Gagarina; Гагарина Н В; V A Sulimov; Сулимов В А; S A Abugov; Абугов С А; E V Zaklyaz'minskaya; Заклязьминская Е В; A E Donnikov; Донников А Е; V V Kadochnikova; Кадочникова В В; A G Kupriyanova; Куприянова А Г; V A Zaydenov; Зайденов В А; L V Beletskaya; Белецкая Л В; O V Blagova; Blagova O V; A V Nedostup; Nedostup A V; E A Kogan; Kogan E A; S L Dzemeshkevich; Dzemeshkevich S L; Yu V Frolova; Frolova Yu V; V P Sedov; Sedov V P; N V Gagarina; Gagarina N V; V A Sulimov; Sulimov V A; S A Abugov; Abugov S A; E V Zaklyazminskaya; Zaklyazminskaya E V; A E Donnikov; Donnikov A E; V V Kadochnikova; Kadochnikova V V; A G Kupriyanova; Kupriyanova A G; V A Zaidenov; Zaidenov V A; L V Beletskaya; Beletskaya L V

Dilated cardiomyopathy as a clinical syndrome: experience with nosological diagnosis with biopsy and treatment approaches

Authors: Blagova O.V.¹, Nedostup AV¹, Kogan EA¹, Dzemeshkevich SL², Frolova Y.V², Sedov VP¹, Gagarina NV¹, Sulimov VA¹, Abugov SA², Zaklyaz'minskaya EV², Donnikov AE³, Kadochnikova VV³, Kupriyanova AG⁴, Zaydenov VA⁴, Beletskaya LV⁴, Blagova OV⁵, Nedostup AV⁵, Kogan EA⁵, Dzemeshkevich SL⁶, Frolova Y.V⁶, Sedov VP⁵, Gagarina NV⁵, Sulimov VA⁵, Abugov SA⁶, Zaklyazminskaya EV⁶, Donnikov AE⁷, Kadochnikova VV⁷, Kupriyanova AG⁸, Zaidenov VA⁸, Beletskaya LV⁸
Affiliations:
1. ГОУ ВПО Первый Московский государственный медицинский университет им. И. М. Сеченова
2. Российский научный центр хирургии им. акад. Б. В. Петровского РАМН
3. Компания "ДНК-технология", Москва
4. ФНЦ трансплантологии и искусственных органов им. акад. В. И. Шумакова
5. I.M. Sechenov State Medical University, Moscow
6. B.V. Petrovsky Russian Research Surgical Center, RAMS, Moscow
7. "DNA-technology" company, Moscow
8. V.I. Shumakov Research Center for Transplantology and Artificial Organs Center
Issue: Vol 83, No 9 (2011)
Pages: 41-48
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30915
ID: 30915

Cite item

Abstract

Aim. To study possibility of nosological diagnosis in patients with dilated cardiomyopathy (DCMP) with use of myocardial biopsy.
Material and methods. The trial enrolled 62 patients (23 females) with DCMP syndrome (end diastolic left ventricular size > 5.5 cm, ejection fraction < 55%). Mean age of the patients was 46.0±12.8 years. The examination included diagnosis of viral infections (Herpes virus, parvovirus B19), measurement of anticardial antibodies titer, 99Tc-MIBI single photon emission computed tomography of the myocardium, multislice computed tomography, MRT of the heart, coronarography, morphological study of the myocardium (n = 20) with application of polymerase chain reaction (PCR) for H.simplex viruses of types 1, 2 and 6, herpes zoster, Epstein-Barr, cytomegalovirus, parvovirus B-19, adenoviruses. The control group (20 operated patients with valvular heart disease and coronary heart disease) was examined for viral genome in the blood and myocardium.
Results. Complex examination of DCMP patients showed the following distribution by nosological entuities: myocarditis (n = 41, 66.1%) including virus-positive (n = 14), primary DCMP (n = 16, 25.9%) including with non-compact myocarditis (NCM) in 3, with debute at delivery of the child - in 3. Arrhythmogenic right ventricular dysplasia combined with viral myocarditis (n = 2), genetic myopathy (n = 1) and Takayasu disease (n = 1) combined with NCM, isolated NCM (n = 1) were diagnosed in the rest cases. Morphological investigation of the myocardium was made in 20 patients: diagnosis of myocarditis and primary DCMP were made in 70% (including in 2 patients with CHD) and 20%. Detection of viral genome was 20 and 15% in the study and control group, respectively, in the myocardium - in 57.9 (test for parvovirus B19 was not made in 26%) and 65.0% (complete diagnosis).All the virus-positive patients with DCMP were diagnosed to have signs of active/borderline myocarditis. Diagnostic criteria and poor prognosis factors were defined.
Conclusion. The nosological diagnosis of DCMP was made in all the examinees basing on the complex of clinical, case history and device evidence. The diagnosis was morphologically verified in 33.9% patients. Treatment approaches are developed.

Keywords

dilated cardiomyopathy, myocarditis, non-compact myocardium, arrythmogenic dysplasia of the right ventricle, herpetic viruses, parvovirus B19, PCR diagnosis, anticardial antibodies, myocardial biopsy, myocarditis treatment

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Dilated cardiomyopathy as a clinical syndrome: experience with nosological diagnosis with biopsy and treatment approaches

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