Current methods of diagnosis and monitoring of a systemic amyloidosis course
- Authors: Rameev V.V.1, Kozlovskaya L.V.1, Malinina E.A.1, Serova A.G.1, Kogarko I.N.2, Kogarko B.S.2, Lyubimova N.V.3, Rameev VV4, Kozlovskaya LV4, Malinina EA4, Serova AG4, Kogarko IN5, Kogarko BS5, Lyubimova NV6
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Affiliations:
- Первый МГМУ им. И. М. Сеченова
- Институт химической физики им. Н. Н. Семенова РАН
- Российский онкологический научный центр им. Н. Н. Блохина РАМН
- I.M. Sechenov First Moscow State Medical University
- N.N. Semenov Institute of Chemical Physics, Moscow
- N.N. Blokhin Russian Cancer Research Center, Moscow
- Issue: Vol 83, No 8 (2011)
- Pages: 48-54
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30902
- ID: 30902
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Full Text
Abstract
Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis.
Results. Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome.
Conclusion. Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy.
About the authors
Vilen Vilevich Rameev
Первый МГМУ им. И. М. Сеченова
Email: vvrameev@mtu-net.ru
канд. мед. наук, асс. каф. терапии и профболезней медико-профилактического фак-та Первого МГМУ им. И. М. Сеченова, тел.: 8-499-248-25-40; Первый МГМУ им. И. М. Сеченова
Lidiya Vladimirovna Kozlovskaya
Первый МГМУ им. И. М. Сеченовад-р мед. наук, проф., каф. терапии и профболезней медико-профилактического фак-та Первого МГМУ им. И. М. Сеченова, тел.: 8-499-248-53-33; Первый МГМУ им. И. М. Сеченова
Elena Aleksandrovna Malinina
Первый МГМУ им. И. М. Сеченова
Email: knvpb@mma.ru
аспирант каф. терапии и профболезней медико-профилактического фак-та Первого МГМУ им. И. М. Сеченова; Первый МГМУ им. И. М. Сеченова
Anna Grigor'evna Serova
Первый МГМУ им. И. М. Сеченовазав. межклинической лаб. иммунологии Первого МГМУ им. И. М. Сеченова, тел.: 8-499-248-41-46; Первый МГМУ им. И. М. Сеченова
Ivetta Nikolaevna Kogarko
Институт химической физики им. Н. Н. Семенова РАНд-р мед. наук, проф., зав. лаб., Ин-т химической физики им. Н. Н. Семенова РАН; Институт химической физики им. Н. Н. Семенова РАН
Bronislav Stanislavovich Kogarko
Институт химической физики им. Н. Н. Семенова РАНд-р хим. наук, вед. науч. сотр., Ин-т химической физики им. Н. Н. Семенова РАН; Институт химической физики им. Н. Н. Семенова РАН
Nina Vasil'evna Lyubimova
Российский онкологический научный центр им. Н. Н. Блохина РАМНканд. мед. наук, зав. лаб. биохимии, Онкологический научный центр им. Н. Н. Блохина РАМН, тел.: 8-495-324-26-04; Российский онкологический научный центр им. Н. Н. Блохина РАМН
V V Rameev
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
L V Kozlovskaya
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
E A Malinina
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
A G Serova
I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical University
I N Kogarko
N.N. Semenov Institute of Chemical Physics, MoscowN.N. Semenov Institute of Chemical Physics, Moscow
B S Kogarko
N.N. Semenov Institute of Chemical Physics, MoscowN.N. Semenov Institute of Chemical Physics, Moscow
N V Lyubimova
N.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, Moscow
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