Use of various nutritional support regimens in patients with transplanted hematopoietic stem cells
- Authors: Kucher M.A.1, Goloshchapov O.V.1, Ganapiev A.A.1, Afanas'ev B.V.1, Kucher MA2, Goloshchapov OV2, Ganapiyev AA2, Afanasyev BV2
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Affiliations:
- Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
- I.P. Pavlov Saint Petersburg State Medical University
- Issue: Vol 82, No 12 (2010)
- Pages: 43-47
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30751
- ID: 30751
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Abstract
Subjects and methods. Fifty-three patients, who had been diagnosed as acute myeloblastic (n = 19) or acute lymphoblastic (n = 16) leukemias, lymphomas (n = 10), and other oncohematological diseases (n = 8) and had received large-dose polychemotherapy followed by hematopoietic stem cell transplantation (HSCT), were prospectively examined.
The control group (n = 27) used standard NS (NS was prescribed when gastrointestinal (GI) events occurred; on day 1 after HSCT, the study group (n = 26) had modified NS added by glutamine dipeptide (0.57 g/kg/day). Energy demands were 35 kcal/kg/day; protein requirements were 1.5-1.7 g/kg/day. Artificial nutrition preparations were daily given through infusion pumps for 24 hours. In both groups, the criteria for NS discontinuation were natural assimilation of 60% of the required energy within 3 consecutive days or day 14 after HSCT when GI function was preserved.
Results. The patients receiving modified NS showed reductions in the incidence and severity of mucositis (p = 0.05), a less significant decrease in the laboratory and anthropometric indicators of nutritional status (p = 0.01), and a better hospital outcome on day 100 after HSCT (p = 0.01). There were no differences in the rate and severity of acute graft-versus-host reaction (p = 0.7%) and in one-year overall survival (p = 0.7%).
Conclusion. As compared with standard NS, modified NS enables a patient to sustain negative consequences of the conditioning regimen, HSCT in the early posttransplantation period.
About the authors
Maksim Anatol'evich Kucher
Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
Email: doctorkucher@yandex.ru
Кафедра гематологии, трансфузиологии и трансплантологии- аспирант каф. гематологии, трансфузиологии и трансплантологии, Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова, тел. 8-812-233-29-25; Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
Oleg Valer'evich Goloshchapov
Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаКафедра гематологии, трансфузиологии и трансплантологии- врач анестезиолог-реаниматолог, зав. отд-нием реанимации и интенсивной терапии, Институт детской гематологии и трансплантологии им. Р. М. Горбачевой, тел.: 8-812-233-29-25; Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
Abdulbasir Abdurakhmanovich Ganapiev
Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаКафедра гематологии, трансфузиологии и трансплантологии; Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
Boris Vladimirovich Afanas'ev
Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаКафедра гематологии, трансфузиологии и трансплантологии- д-р мед. наук, проф., зав. каф. гематологии, трансфузиологии и трансплантологии, Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова, дир. Института детской гематологии и трансплантологии им. Р. М. Горбачевой, тел.: 8-812-233-47-51; Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова
M A Kucher
I.P. Pavlov Saint Petersburg State Medical UniversityI.P. Pavlov Saint Petersburg State Medical University
O V Goloshchapov
I.P. Pavlov Saint Petersburg State Medical UniversityI.P. Pavlov Saint Petersburg State Medical University
A A Ganapiyev
I.P. Pavlov Saint Petersburg State Medical UniversityI.P. Pavlov Saint Petersburg State Medical University
B V Afanasyev
I.P. Pavlov Saint Petersburg State Medical UniversityI.P. Pavlov Saint Petersburg State Medical University
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