Complex assessment of esophageal acidification and motor function in patients with Barrett's esophagus on antisecretory therapy
- Authors: Maev I.V.1, Barkalova E.V.1, Andreev D.N.1, Ovsepian M.A.1, Movtaeva P.R.1, Zayratyants O.V.1
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Affiliations:
- Yevdokimov Moscow State University of Medicine and Dentistry
- Issue: Vol 93, No 12 (2021)
- Pages: 1463-1469
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/96443
- DOI: https://doi.org/10.26442/00403660.2021.12.201278
- ID: 96443
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Abstract
Aim. To determine predictors of insufficient effectiveness of proton pump inhibitors based on the parameters of 24-hours pH-impedance and features of motor function of the esophagus in patients with Barrett's esophagus.
Materials and methods. 17 patients with histologically verified Barrett's esophagus undergoing acid-suppressive therapy were examined. All patients underwent 24-hours pH-impedance and high-resolution esophageal manometry.
Results. According to daily pH-impedance, group 1 consisted of 11 patients with an adequate response to antisecretory therapy, group 2 – 6 patients with insufficient effectiveness of antisecretory therapy, 5 of whom had no clinical manifestations. The total number of reflux averaged 52 and 91, respectively, in groups 1 and 2. The average number of acid reflux in group 1 was 4.36, in group 2 – 40.5. The average number of non-acid reflux prevailed in patients of group 2, averaging 58, compared with group 1, where the average was 47. According to the results of high-resolution esophageal manometry, when assessing the structure and function of the esophageal-gastric junction, violations were detected in 6 out of 17 patients. Disorders of the motor function of the thoracic esophagus were detected in 10 out of 17 patients. The tone of the lower esophageal sphincter in group 1 patients was significantly higher in comparison with patients in group 2.
Conclusion. A number of patients with Barrett's esophagus have insufficient effectiveness of antisecretory therapy, which may not manifest itself clinically and thereby increase the risk of progression. There was a tendency to more frequent motor disorders in the group with insufficient effectiveness of antisecretory therapy, as well as significantly lower tone of the lower esophageal sphincter, which may be a potential predictor of suboptimal effectiveness of antisecretory therapy.
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##article.viewOnOriginalSite##About the authors
Igor V. Maev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: maslovaalena@mail.ru
ORCID iD: 0000-0001-6114-564X
акад. РАН, д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowElena V. Barkalova
Yevdokimov Moscow State University of Medicine and Dentistry
Author for correspondence.
Email: maslovaalena@mail.ru
ORCID iD: 0000-0001-5882-9397
ассистент каф. пропедевтики внутренних болезней и гастроэнтерологии, рук. лаб. функциональных методов исследования в гастроэнтерологии
Russian Federation, MoscowDmitry N. Andreev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: maslovaalena@mail.ru
ORCID iD: 0000-0002-4007-7112
канд. мед. наук, доц. каф. пропедевтики внутренних болезней и гастроэнтерологии, науч. сотр. лаб. функциональных методов исследования в гастроэнтерологии
Russian Federation, MoscowMariia A. Ovsepian
Yevdokimov Moscow State University of Medicine and Dentistry
Email: maslovaalena@mail.ru
ORCID iD: 0000-0003-4511-6704
ст. лаб. каф. пропедевтики внутренних болезней и гастроэнтерологии, науч. сотр. лаб. функциональных методов исследования в гастроэнтерологии
Russian Federation, MoscowPetimat R. Movtaeva
Yevdokimov Moscow State University of Medicine and Dentistry
Email: maslovaalena@mail.ru
ORCID iD: 0000-0002-2716-625X
соискатель каф. пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowOleg V. Zayratyants
Yevdokimov Moscow State University of Medicine and Dentistry
Email: maslovaalena@mail.ru
ORCID iD: 0000-0003-3606-3823
д-р мед. наук, проф., зав. каф. патологической анатомии
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