Myocardial remodeling in patients with chronic heart failure and implanted cardiac contractility modulators

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Abstract

Aim. To study the effect of cardiac contractility modulation on reverse remodeling and myocardial function in patients with chronic heart failure (HF) according to echocardiography (EchoCG).

Materials and methods. In a group of 40 patients with a combination of chronic HF and atrial fibrillation (AF), the dynamics of standard EchoCG parameters and the effectiveness of myocardial work of the left ventricle (LV) against the background of 12-month therapy of cardiac contractility modulation (CCM) were analyzed.

Results. The results obtained indicate a statistically significant positive effect of CCM on LV remodeling parameters and the effectiveness of myocardial work according to EchoCG.

Conclusion. Transthoracic echocardiography is the main imaging method and provides great opportunities for evaluating the effectiveness of HF treatment, including non-drug methods such as CCM. Evaluation of LV myocardial function in patients with HF and implanted CCM devices is a promising scientific and practical research method.

About the authors

Alfiya A. Safiullina

National Medical Research Center of Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-3483-4698

канд. мед. наук, науч. сотр. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

Tatiana M. Uskach

National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-4318-0315

д-р мед. наук, вед. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова, проф. каф. Кардиологии

Russian Federation, Moscow; Moscow

Svetlana V. Dobrovolskaya

National Medical Research Center of Cardiology

Author for correspondence.
Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-0580-393X

врач отд. ультразвуковых методов исследования Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

Marina A. Saidova

National Medical Research Center of Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-3233-1862

д-р мед. наук, проф., рук. отд. ультразвуковых методов исследования Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

Igor V. Zhirov

National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-4066-2661

д-р мед. наук, вед. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова, проф. каф. кардиологии

Russian Federation, Moscow; Moscow

Sergey N. Tereshchenko

National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0001-9234-6129

д-р мед. наук, проф., рук. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова, зав. каф. кардиологии

Russian Federation, Moscow; Moscow

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2. Fig. 1. The main indicators of the left ventricular yocardium.

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