Dynamics of Holter electrocardiogram monitoring in patients with chronic heart failure and atrial fibrillation on the background of cardiac contractility modulation

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Abstract

Aim. To evaluate the dynamics of cardiac arrhythmias on the background of cardiac contractility modulation (MCC) in patients with chronic heart failure (CHF) and various forms of atrial fibrillation (AF) on the basis of daily electrocardiogram (ECG) monitoring.

Materials and methods. In 100 patients with CHF and AF, the following studies were performed before implantation of the MCC device and after 12 months of follow-up: 12-channel ECG with an estimate of the width of the QRS complex, transthoracic echocardiography (EchoCG), and Holter ECG monitoring. All patients received long-term optimal drug therapy for CHF before surgery.

Results. The results obtained indicate that there is no effect of MCC on the development and progression of ventricular arrhythmias in patients with CHF and AF during the year of follow-up, both extrasystole and tachyarrhythmias, regardless of the etiology and LVEF (less than 35% or more than 35%), and a decrease in the frequency of AF paroxysms in patients with CHF during treatment. These results are due to the reverse remodeling of the LV myocardium under the influence of the MCC device.

Conclusion. The use of MСС in patients with CHF and AF is a safe method of therapy that does not induce cardiac arrhythmias, including ventricular extrasystole. Large-scale comparative studies are required to evaluate these results.

About the authors

Alfiya A. Safiullina

National Medical Research Center of Cardiology

Author for correspondence.
Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-3483-4698

канд. мед. наук, науч. сотр. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

Tatiana M. Uskach

National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-4318-0315

д-р мед. наук, вед. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии», проф. каф. кардиологии ФГБУ ДПО РМАНПО

Russian Federation, Moscow; Moscow

Yulduz S. Sharapova

National Medical Research Center of Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-4767-198X

врач-аспирант отд. заболеваний миокарда и сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

Anatolii G. Kochetov

People’s Friendship University of Russia (RUDN University); Institute of Laboratory Medicine

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-3632-291X

д-р мед. наук, проф. каф. госпитальной терапии с курсом клинической лабораторной диагностики ФГАОУ ВО РУДН, ректор АНО ДПО «Институт лабораторной медицины»

Russian Federation, Moscow; Moscow

Oleg V. Sapelnikov

National Medical Research Center of Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-5186-2474

д-р мед. наук, рук. лаб. хирургических и рентгенохирургических методов лечения нарушений ритма сердца отд. сердечно-сосудистой хирургии ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

Sergey N. Tereshchenko

National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0001-9234-6129

д-р мед. наук, проф., рук. отд. заболеваний миокарда сердечной недостаточности Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии», зав. каф. кардиологии ФГБУ ДПО РМАНПО

Russian Federation, Moscow; Moscow

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