Experience of using a triple fixed combination in the treatment of patients with chronic obstructive pulmonary disease

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Abstract

Aim. To evaluate the effectiveness of a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate in the treatment of chronic obstructive pulmonary disease (COPD) patients with frequent exacerbations.

Materials and methods. The study included 46 patients with severe and extremely severe COPD (GOLD 3–4) with frequent exacerbations. All patients were divided into 2 groups. The 1st group included 22 COPD patients with a content of eosinophils in the peripheral blood of ≥300 cells/ml, the 2nd group included 24 COPD patients with no signs of eosinophilic inflammation in the peripheral blood. Group 1 patients were recommended therapy with a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate at a dose of 22/55/92 mcg 1 time per day, group 2 patients received vilanterol+umeclidinium bromide at a dose of 22/55 mcg 1 time per day. The duration of follow-up was 12 months.

Results. After 12 months of treatment with a fixed triple combination of vilanterol/umeclidinium bromide/fluticasone furoate, a statistically significant decrease in peripheral blood eosinophilia was noted in patients with COPD with frequent exacerbations and peripheral blood eosinophilia (p=0.001), as well as a decrease in shortness of breath on the MMRs scale (p=0.001) and the frequency of exacerbations in patients with COPD with frequent exacerbations and eosinophilia (p=0.001).

Conclusion. The use of a fixed combination of vilanterol/umeclidinium bromide/fluticasone furoate for 12 months allowed to reduce the impact of the disease, improve respiratory function and quality of life in COPD patients with eosinophilia.

About the authors

Elena V. Bolotova

Kuban State Medical University

Email: avdudnikova@yandex.ru
ORCID iD: 0000-0001-6257-354X
SPIN-code: 4322-9985

д-р мед. наук, проф., проф. каф. терапии №1 фак-та повышения квалификации и последипломной подготовки специалистов

Russian Federation, Krasnodar

Anna V. Dudnikova

Kuban State Medical University

Author for correspondence.
Email: avdudnikova@yandex.ru
ORCID iD: 0000-0003-2601-7831
SPIN-code: 7480-1992
Scopus Author ID: 57200810048
ResearcherId: K-1110-2016

канд. мед. наук, врач-терапевт консультативно-диагностического отд-ния

Russian Federation, Krasnodar

Larisa V. Shulzhenko

Kuban State Medical University; Ochapovsky Regional Clinical Hospital No.1

Email: avdudnikova@yandex.ru
ORCID iD: 0000-0002-2110-0970
SPIN-code: 1140-8084

д-р мед. наук, зав. каф. пульмонологии фак-та повышения квалификации и последипломной подготовки специалистов; зав. пульмонологическим отд-нием

Russian Federation, Krasnodar; Krasnodar

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2. Fig. 1. Dynamics of scores of the SGRQ questionnaire against the background of ongoing treatment (n=46).

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