Rational treatment of patients with functional dyspepsia
- Authors: Kazakov A.S.1, Zyryanov S.K.1, Ushkalova E.A.1, Nasretdinova E.K.2
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Affiliations:
- People’s Friendship University of Russia (RUDN University)
- Children’s Medical Center Office of the President of the Russian Federation
- Issue: Vol 93, No 8 (2021)
- Pages: 982-985
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/79597
- DOI: https://doi.org/10.26442/00403660.2021.08.200984
- ID: 79597
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Abstract
Functional dyspepsia is one of the most common functional disorders of the gastrointestinal tract, which resulted from impaired motor skills, visceral hypersensitivity, increased mucosal permeability, disorders of the autonomic nervous system, etc. There is no specific therapy for this disease, which often leads to the irrational use of various groups of drugs. Drug therapy is recommended only during periods of symptoms. The main options of pharmacotherapy include the use of proton pump inhibitors, phytotherapeutic drugs, eradication therapy of Helicobacter pylori. Against the background of possible motor disorders, prokinetics are also one of the possible treatment options, but cisapride has long been withdrawn from sale due to cardiotoxicity, the use of domperidone and metoclopramide is limited due to side effects, especially with long-term therapy, so currently the only prokinetic that can be used in everyday clinical practice is itopride. In refractory cases, tricyclic antidepressants and psychotherapeutic approaches are another effective treatment option.
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##article.viewOnOriginalSite##About the authors
Alexander S. Kazakov
People’s Friendship University of Russia (RUDN University)
Author for correspondence.
Email: eushk@yandex.ru
ORCID iD: 0000-0003-2665-796X
кандидат медицинских наук, ассистент кафедры общей и клин. фармакологии
Russian Federation, MoscowSergey K. Zyryanov
People’s Friendship University of Russia (RUDN University)
Email: eushk@yandex.ru
ORCID iD: 0000-0002-6348-6867
доктор медицинских наук, профессор, заведующий кафедрой общей и клин. фармакологии
Russian Federation, MoscowElena A. Ushkalova
People’s Friendship University of Russia (RUDN University)
Email: eushk@yandex.ru
ORCID iD: 0000-0003-4165-1726
доктор медицинских наук, профессор, профессор кафедры общей и клин. фармакологии
Russian Federation, MoscowElena K. Nasretdinova
Children’s Medical Center Office of the President of the Russian Federation
Email: eushk@yandex.ru
ORCID iD: 0000-0003-4310-7708
врач-гастроэнтеролог
Russian Federation, MoscowReferences
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