Roles of active forms of vitamin D in supporting innate immune systems and in reducing excess inflammation in COVID-19

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Abstract

A reduced supply of micronutrient vitamin D leads to a more severe course of coronavirus infection (COVID-19). Vitamin D deficiency is combined with a decrease in innate antiviral immunity and excess of inflammation. Vitamin D supplementation stimulates the synthesis of antibacterial peptides and is important for weakening the cytokine storm, reducing excessive acute and chronic inflammation, and also for compensating for chronic comorbid pathologies. Active forms of vitamin D (alfacalcidol, etc.) are of particular importance for compensating for vitamin D deficiency in elderly patients, endocrine-immune dysfunction, sarcopenia, chronic renal failure (in which the metabolism of vitamin D in the kidneys is disturbed).

About the authors

Olga A. Gromova

Computer Science and Control; Northern State Medical University

Author for correspondence.
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-7663-710X

доктор медицинских наук, профессор, ведущий научный сотрудник, науч. руководитель Института фармакоинформатики, ведущий научный сотрудник  СГМУ

Russian Federation, Moscow; Arkhangelsk

Ivan I. Torshin

Computer Science and Control; Northern State Medical University

Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-2659-7998

кандидат физико-математических наук, кандидат химических наук, старший научный сотрудник Института фармакоинформатики, ведущий научный сотрудник

Russian Federation, Moscow; Arkhangelsk

Alexander G. Chuchalin

Pirogov Russian National Research Medical University

Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-5070-5450

академик РАН, заведующий кафедрой госпитальной терапии педиатрического факультета РНИМУ, пульмонолог 

Russian Federation, Moscow

Elena N. Kozhevnikova

Institute of General Pathology and Pathophysiology

Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-5965-5592

кандидат медицинских наук, ведущий научный сотрудник, исполняющий обязанности руководителя научно-аналитического отделение

Russian Federation, Moscow

Svetlana I. Malyavskaya

Northern State Medical University

Email: unesco.gromova@gmail.com
ORCID iD: 0000-0003-2521-0824

доктор медицинских наук, профессор, проректор по научной работе

Russian Federation, Arkhangelsk

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2. Fig. 1. Molecular mechanisms of the effect of vitamin D on human physiology.

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3. Fig. 2. Correspondence between changes in protein levels in the dynamics of COVID-19 progression and changes in transcription of the corresponding genes when exposed to active forms of vitamin D.

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