Roles of active forms of vitamin D in supporting innate immune systems and in reducing excess inflammation in COVID-19
- Authors: Gromova O.A.1,2, Torshin I.I.1,2, Chuchalin A.G.3, Kozhevnikova E.N.4, Malyavskaya S.I.2
-
Affiliations:
- Computer Science and Control
- Northern State Medical University
- Pirogov Russian National Research Medical University
- Institute of General Pathology and Pathophysiology
- Issue: Vol 93, No 8 (2021)
- Pages: 948-953
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/79550
- DOI: https://doi.org/10.26442/00403660.2021.08.200918
- ID: 79550
Cite item
Full Text
Abstract
A reduced supply of micronutrient vitamin D leads to a more severe course of coronavirus infection (COVID-19). Vitamin D deficiency is combined with a decrease in innate antiviral immunity and excess of inflammation. Vitamin D supplementation stimulates the synthesis of antibacterial peptides and is important for weakening the cytokine storm, reducing excessive acute and chronic inflammation, and also for compensating for chronic comorbid pathologies. Active forms of vitamin D (alfacalcidol, etc.) are of particular importance for compensating for vitamin D deficiency in elderly patients, endocrine-immune dysfunction, sarcopenia, chronic renal failure (in which the metabolism of vitamin D in the kidneys is disturbed).
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Olga A. Gromova
Computer Science and Control; Northern State Medical University
Author for correspondence.
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-7663-710X
доктор медицинских наук, профессор, ведущий научный сотрудник, науч. руководитель Института фармакоинформатики, ведущий научный сотрудник СГМУ
Russian Federation, Moscow; ArkhangelskIvan I. Torshin
Computer Science and Control; Northern State Medical University
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-2659-7998
кандидат физико-математических наук, кандидат химических наук, старший научный сотрудник Института фармакоинформатики, ведущий научный сотрудник
Russian Federation, Moscow; ArkhangelskAlexander G. Chuchalin
Pirogov Russian National Research Medical University
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-5070-5450
академик РАН, заведующий кафедрой госпитальной терапии педиатрического факультета РНИМУ, пульмонолог
Russian Federation, MoscowElena N. Kozhevnikova
Institute of General Pathology and Pathophysiology
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0002-5965-5592
кандидат медицинских наук, ведущий научный сотрудник, исполняющий обязанности руководителя научно-аналитического отделение
Russian Federation, MoscowSvetlana I. Malyavskaya
Northern State Medical University
Email: unesco.gromova@gmail.com
ORCID iD: 0000-0003-2521-0824
доктор медицинских наук, профессор, проректор по научной работе
Russian Federation, ArkhangelskReferences
- Han H, Yang L, Liu R, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med. 2020; 58(7):1116-20. doi: 10.1515/cclm-2020-0188
- Wang Z, Yang B, Li Q, et al. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis. 2020;71(15):769-77. doi: 10.1093/cid/ciaa272
- Peng YD, Meng K, Guan HQ, et al. Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV. Zhonghua Xin Xue Guan Bing Za Zhi. 2020;48(0):E004. doi: 10.3760/cma.j.cn112148-20200220-00105
- Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020;5(7):831-40. doi: 10.1001/jamacardio.2020.1286. PMID: 32219363
- Торшин И.Ю., Громова О.А. Под ред. А.Г. Чучалина. Микронутриенты против коронавирусов. М.: ГЭОТАР-Медиа, 2020 [Torshin IYu, Gromova OA. Ed. AG Chuchalin. Micronutrients against coronaviruses. Moscow: GEOTAR-Media, 2020 (in Russian)].
- Громова О.А., Торшин И.Ю. Витамин D. Смена парадигмы, 2-е изд., перераб. и доп. (ред. Е.И. Гусев, И.Н. Захарова). М.: ГЭОТАР-Медиа, 2021 [Gromova OA, Torshin IYu. Vitamin D. Paradigm shift, 2nd ed., Revised. and add. Moscow: GEOTAR-Media, 2021 (in Russian)].
- De Smet D, De Smet K, Herroelen P, et al. Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality. Am J Clin Pathol. 2021;155(3):381-8. doi: 10.1093/ajcp/aqaa252. PMID: 33236114
- Maghbooli Z, Sahraian MA, Ebrahimi M, et al. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS One. 2020;15(9):e0239799. doi: 10.1371/journal.pone.0239799
- Hurwitz JL, Jones BG, Penkert RR, et al. Low retinol-binding protein and vitamin D levels are associated with severe outcomes in children hospitalized with lower respiratory tract infection and respiratory syncytial virus or human metapneumovirus detection. J Pediatr. 2017;187:323-7. doi: 10.1016/j.jpeds.2017.04.061
- Громова О.А., Торшин И.Ю., Габдулина Г.Х. Пандемия COVID-19: защитные роли витамина D. Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2020;13(2):132-45 [Gromova OA, Torshin IYu, Gabdulina GKh. COVID-19 pandemic: protective role of vitamin D. Farmakoekonomika. Modern Pharmacoeconomic and Pharmacoepidemiology. 2020;13(2):132-45 (in Russian)]. doi: 10.17749/2070-4909/farmakoekonomika.2020.044
- Colotta F, Jansson B, Bonelli F. Modulation of inflammatory and immune responses by vitamin D. J Autoimmun. 2017;85:78-97. doi: 10.1016/j.jaut.2017.07.007
- Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011;50(3):194-200. doi: 10.1016/j.jcv.2010.12.006
- Charan J, Goyal JP, Saxena D, Yadav P. Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis. J Pharmacol Pharmacother. 2012;3(4):300-3. doi: 10.4103/0976-500X.103685
- Grant WB, Goldstein M, Mascitelli L. Ample evidence exists from human studies that vitamin D reduces the risk of selected bacterial and viral infections. Exp Biol Med (Maywood). 2010;235(12):1395-6; discussion 1397. doi: 10.1258/ebm.2010.010c01
- Wang G. Human antimicrobial peptides and proteins. Pharmaceuticals (Basel). 2014;7(5):545-94. doi: 10.3390/ph7050545
- Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am. 2017;46(4):1061-94. doi: 10.1016/j.ecl.2017.07.010
- Vanherwegen AS, Gysemans C, Mathieu C. Vitamin D endocrinology on the cross-road between immunity and metabolism. Mol Cell Endocrinol. 2017;453:52-67. doi: 10.1016/j.mce.2017.04.018
- Scherberich JE, Kellermeyer M, Ried C, Hartinger A. 1-alpha-calcidol modulates major human monocyte antigens and toll-like receptors TLR 2 and TLR4 in vitro. Eur J Med Res. 2005;10(4):179-82. PMID: 15946915
- Huraib S, Tanimu D, Abu-Romeh S, et al. Effect of intravenous alfacalcidol on lymphocyte phenotyping in hemodialysis patients. Am J Kidney Dis. 1998;32(6):1036-40. doi: 10.1016/s0272-6386(98)70080-0
- Zold E, Szodoray P, Nakken B, et al. Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease. Autoimmun Rev. 2011;10(3):155-62. doi: 10.1016/j.autrev.2010.09.018
- Atsukawa M, Tsubota A, Shimada N, et al. Efficacy of Alfacalcidol on PEG-IFN/Ribavirin combination therapy for elderly patients with chronic hepatitis C: a pilot study. Hepat Mon. 2013;13(12):e14872. doi: 10.5812/hepatmon.14872
- Su Y, Chen D, Yuan D, et al. Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19. Cell. 2020;183(6):1479-95.e20. doi: 10.1016/j.cell.2020.10.037
- Торшин И.Ю., Громова О.А., Фролова Д.Е., и др. Дозозависимый хемотранскриптомный анализ дифференциального действия витамина D на экспрессию генов в клетках-предшественниках нейронов NPC и в опухолевых клетках MCF7 человека. Фармакокинетика и фармакодинамика. 2018;2:35-51 [Torshin IYu, Gromova OA, Frolova DE, et al. Dose-dependent chemotranscriptomics analysis of the differential effects of vitamin D on gene expression in human neuronal progenitor cells NPC and in MCF7 tumor cells. Pharmacokinetics and Pharmacodynamics. 2018;2:35-51 (in Russian)]. doi: 10.24411/2587-7836-2018-10013
- Ali RM, Al-Shorbagy MY, Helmy MW, El-Abhar HS. Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone. Eur J Pharmacol. 2018;831:68-76. doi: 10.1016/j.ejphar.2018.04.032
- Yang X, Wu L, Li G, et al. Alphacalcidol combined with dexamethasone for reducing pulmonary fibrosis in mice and its mechanism. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33(4):488491. PMID: 28395719
- Rizka A, Setiati S, Harimurti K, et al. Effect of Alfacalcidol on inflammatory markers and T cell subsets in elderly with frailty syndrome: a double blind randomized controlled trial. Acta Med Indones. 2018;50(3):215-21. PMID: 30333271
- Liu C, Jiang ZC, Shao CX, et al. Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study. Zhonghua Gan Zang Bing Za Zhi. 2020;28(2):148-52. doi: 10.3760/cma.j.issn.1007-3418.2020.02.003
- Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7. doi: 10.1111/jth.14768
- Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-5. doi: 10.1016/j.ijid.2020.03.017
- Ali AM, Selim S, Abbassi MM, Sabry NA. Effect of alfacalcidol on the pulmonary function of adult asthmatic patients: a randomized trial. Ann Allergy Asthma Immunol. 2017;118(5):557-63. doi: 10.1016/j.anai.2017.02.014
- Abdel-Rehim WM, El-Tahan RA, El-Tarawy MA, et al. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes. Mol Cell Biochem. 2019;450(1-2):105-12. doi: 10.1007/s11010-018-3377-x
- Ataie-Jafari A, Loke SC, Rahmat AB, et al. A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes. Clin Nutr. 2013;32(6):911-7. doi: 10.1016/j.clnu.2013.01.012
- Mirzaei K, Hossein-Nezhad A, Keshavarz SA, et al. Insulin resistance via modification of PGC1α function identifying a possible preventive role of vitamin D analogues in chronic inflammatory state of obesity. A double blind clinical trial study. Minerva Med. 2014;105(1):63-78. PMID: 24572452
- Ureña-Torres PA, Cozzolino M, Bover J. Utilization of alfacalcidol and active vitamin D analogs in chronic kidney disease. Nephrol Ther. 2018;14(4):189-200. doi: 10.1016/j.nephro.2017.03.003
- Zand L, Kumar R. The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease. Endocrinol Metab Clin North Am. 2017;46(4):983-1007. doi: 10.1016/j.ecl.2017.07.008
- Громова О.А., Торшин И.Ю., Путилина М.В., и др. Ноцицепция: роли витамина D. Неврология, нейропсихиатрия, психосоматика. 2021;13(1):145-53 [Gromova OA, Torshin IYu, Putilina MV, et al. Nociception: the roles of vitamin D. Neurology, Neuropsychiatry, Psychosomatics. 2021;13(1):145-53 (in Russian)]. doi: 10.14412/2074-2711-2021-1-145-153
- Ringe JD, Farahmand P, Schacht E, Rozehnal A. Superiority of a combined treatment of Alendronate and Alfacalcidol compared to the combination of Alendronate and plain vitamin D or Alfacalcidol alone in established postmenopausal or male osteoporosis (AAC-Trial). Rheumatol Int. 2007;27(5):425-34. doi: 10.1007/s00296-006-0288-z
- Ringe JD, Farahmand P, Schacht E. Alfacalcidol in men with osteoporosis: a prospective, observational, 2-year trial on 214 patients. Rheumatol Int. 2013;33(3):637-43. doi: 10.1007/s00296-012-2429-x
- Jørgensen HS, Winther S, Povlsen JV, Ivarsen P. Effect of vitamin-D analogue on albuminuria in patients with non-dialysed chronic kidney disease stage 4-5: a retrospective single center study. BMC Nephrol. 2012;13:102. doi: 10.1186/1471-2369-13-102.
Supplementary files
![](/img/style/loading.gif)