Risk factors for pancreatitis and pancreatic cancer
- Authors: Grigor’eva I.N.1, Efimova O.V.2
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Affiliations:
- Scientific Research Institute of Therapy and Preventive Medicine – branch of the Federal Scientific Center “Institute of Cytology and Genetics” of the Siberian Branch of the Russian Academy of Sciences
- Medical Unit of the Ministry of Internal Affairs of Russia in Moscow
- Issue: Vol 93, No 8 (2021)
- Pages: 875-882
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/79419
- DOI: https://doi.org/10.26442/00403660.2021.08.200970
- ID: 79419
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Abstract
Aim. To identify and compare the frequency of alcohol consumption, tobacco smoking, levels of main macronutrients, vitamins and mineral elements consumption in patients with acute (AP) and chronic pancreatitis (CP) and pancreatic cancer (PC).
Materials and methods. At the observational clinical cross-sectional uncontrolled case-study 65 patients with AP or CP (group 1) and 45 patients with PC (group 2) were examined. A survey of patients was carried out: questionnaire on tobacco smoking, a frequency questionnaire on alcohol consumption, a questionnaire for assessing the frequency of food consumption.
Results. The frequency of smoking (33.8, 20.0%; p>0.05), alcohol consumption ≥1 times/week during the last year (21.5, 15.6%; p>0.05) did not differ significantly between the two groups. The highest consumption rates of total, vegetable, animal protein, total carbohydrates, refined sugar, animal fat, cholesterol, MUFA, dietary fiber, vitamins (â-carotene, vitamin B1, B2, C, PP), mineral elements (iron, potassium, calcium, magnesium, sodium, phosphorus) and the daily energy content of the diet were determined in PC than in the AP and CP group. Among patients of group 1, deficient intake of fat-soluble vitamin A (93.3, 54.8%; p=0.009) and vitamin E (80.0, 48.4%; p=0.041) was more common in the subgroup of patients with excretory pancreatic insufficiency than without it, and the chance of having hypercholesterolemia was associated with a deficient intake of vitamin E [Ex(B)=3.3, 95% CI 1.5–9.3; p=0.027].
Conclusion. There were no differences in the frequency of smoking and alcohol consumption between patients with AP and CP and PC. The highest indices of the main macronutrients, daily energy content of the diet, micronutrients (except for vitamins A, E) were found in PC than in the group of patients with AP and CP. Among patients with AP and CP with excretory pancreatic insufficiency, a lower intake of fat-soluble vitamins was noted and associations of hypercholesterolemia with deficient intake of vitamin E were obtained.
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##article.viewOnOriginalSite##About the authors
Irina N. Grigor’eva
Scientific Research Institute of Therapy and Preventive Medicine – branch of the Federal Scientific Center “Institute of Cytology and Genetics” of the Siberian Branch of the Russian Academy of Sciences
Email: kukisyak@mail.ru
ORCID iD: 0000-0003-0069-7744
доктор медицинских наук, профессор, главный научный сотрудник лаборатории гастроэнтерологии НИИ терапии и профилактической медицины – филиала ФГБНУ ФИЦ ИЦиГ СО РАН
Russian Federation, NovosibirskOlga V. Efimova
Medical Unit of the Ministry of Internal Affairs of Russia in Moscow
Author for correspondence.
Email: kukisyak@mail.ru
ORCID iD: 0000-0003-1874-8458
кандидат медицинских наук, гастроэнтеролог Клинического госпиталя
Russian Federation, MoscowReferences
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