Multiple primary tumor of hematopoietic tissue: myeloid sarcoma in combination with mantle cell lymphoma. Case report

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Abstract

The prevalence of multiple primary tumors has significantly increased last time. The question of choosing the optimal tactics of therapy today not fully resolved. Particular interest is the simultaneous detection of two neoplasms of similar origin in one study biopsy material. This publication presents a case of simultaneous diagnosis of myeloid sarcoma and mantle cell lymphoma in a 65-year-old patient, which required use of two different chemotherapy protocols. This example shows the need to use an extended diagnostic approach at all stages of the therapy, which allows choosing right tactics of therapy and achieving complete remission of two neoplasms.

About the authors

Olga A. Gavrilina

National Medical Research Center for Hematology

Author for correspondence.
Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0002-9969-8482

канд. мед. наук, зав. обсервационным отд-нием, врач-онколог отд-ния интенсивной высокодозной химиотерапии гемобластозов и депрессий кроветворения

Russian Federation, Moscow

Vitalii S. Dubov

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0001-9105-6568

врач-ординатор отд-ния интенсивной высокодозной химиотерапии гемобластозов и депрессий кроветворения

Russian Federation, Moscow

Vera V. Troitskaya

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0002-4827-8947

канд. мед. наук, зам. дир. по лечебной работе, зав. отд-нием высокодозной химиотерапии гемобластозов и депрессий кроветворения

Russian Federation, Moscow

Alla M. Kovrigina

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0002-1082-8659

д-р биол. наук, зав. патологоанатомическим отд-нием

Russian Federation, Moscow

Valentina N. Dvirnyk

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0002-9877-0796

канд. мед. наук, зав. централизованной клинико-диагностической лаб.

Russian Federation, Moscow

Irina V. Galtseva

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0002-8490-6066

канд. мед. наук, зав. лаб. иммунофенотипирования клеток крови и костного мозга

Russian Federation, Moscow

Andrei B. Sudarikov

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0001-9463-9187

д-р биол. наук, зав. лаб. молекулярной гематологии

Russian Federation, Moscow

Tatiana N. Obukhova

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0003-1613-652X

канд. мед. наук, зав. лаб. кариологии

Russian Federation, Moscow

Elena N. Parovichnikova

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0001-6177-3566

д-р мед. наук, рук. сектора клинических исследований и рекомендаций, рук. отд. высокодозной химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга

Russian Federation, Moscow

Valerii G. Savchenko

National Medical Research Center for Hematology

Email: dr.gavrilina@mail.ru
ORCID iD: 0000-0001-8188-5557

акад. РАН, д-р мед. наук, проф., ген. дир.

Russian Federation, Moscow

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2. Fig. 1. Histological, immunohistochemistry, molecular-genetic and FISH examination, which demonstrate primary multiple tumor lesions of myeloid sarcoma and mantle cell lymphoma: a – histological examination of the lymph nodes – LN (hematoxylin and eosin staining, ×100–400); b – IHC staining of the LN tissues (using antibodies to CD33, CD34, CD19, Cyclin D1, Ki-67, ×100–400); c - analysis of bone marrow cells using FISH test, DNA probe for IG/CCND1; d – determination of B-cell clonality by rearrangement of genes of heavy and light chains of immunoglobulins in biopsy specimens of LN and BM punctate.

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3. Fig. 2. Skin toxicity in the form of erythema and peeling skin on the palms after therapy with cytarabine.

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