Treatment of thrombotic thrombocytopenic purpura

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Abstract

The review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpuгa (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treatment options such as cyclosporin A, bortezomib, splenectomy, N-acetylcysteine, recombinant ADAMTS13 are also described. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.

About the authors

Gennadii M. Galstyan

National Research Center for Hematology

Author for correspondence.
Email: gengalst@gmail.com
ORCID iD: 0000-0001-8818-8949

д-р мед. наук, зав. отд-нием реанимации и интенсивной терапии ФГБУ «НМИЦ гематологии»

Russian Federation, Moscow

Alexei A. Maschan

Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Email: gengalst@gmail.com
ORCID iD: 0000-0002-0016-6698

чл.-кор. РАН, д-р мед. наук, проф., зам. ген. дир. – дир. Института гематологии, иммунологии и клеточных технологий ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева»

Russian Federation, Moscow

Elizaveta E. Klebanova

National Research Center for Hematology

Email: gengalst@gmail.com
ORCID iD: 0000-0002-8141-9422

врач анестезиолог-реаниматолог отд-ния реанимации и интенсивной терапии ФГБУ «НМИЦ гематологии»

Russian Federation, Moscow

Irina I. Kalinina

Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Email: gengalst@gmail.com
ORCID iD: 0000-0002-0813-5626

канд. мед. наук, врач-гематолог отд-ния детской гематологии/онкологии ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева»

Russian Federation, Moscow

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