Treatment of thrombotic thrombocytopenic purpura
- Authors: Galstyan G.M.1, Maschan A.A.2, Klebanova E.E.1, Kalinina I.I.2
-
Affiliations:
- National Research Center for Hematology
- Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
- Issue: Vol 93, No 6 (2021)
- Pages: 736-745
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/75968
- DOI: https://doi.org/10.26442/00403660.2021.06.200894
- ID: 75968
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Abstract
The review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpuгa (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treatment options such as cyclosporin A, bortezomib, splenectomy, N-acetylcysteine, recombinant ADAMTS13 are also described. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.
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##article.viewOnOriginalSite##About the authors
Gennadii M. Galstyan
National Research Center for Hematology
Author for correspondence.
Email: gengalst@gmail.com
ORCID iD: 0000-0001-8818-8949
д-р мед. наук, зав. отд-нием реанимации и интенсивной терапии ФГБУ «НМИЦ гематологии»
Russian Federation, MoscowAlexei A. Maschan
Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
Email: gengalst@gmail.com
ORCID iD: 0000-0002-0016-6698
чл.-кор. РАН, д-р мед. наук, проф., зам. ген. дир. – дир. Института гематологии, иммунологии и клеточных технологий ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева»
Russian Federation, MoscowElizaveta E. Klebanova
National Research Center for Hematology
Email: gengalst@gmail.com
ORCID iD: 0000-0002-8141-9422
врач анестезиолог-реаниматолог отд-ния реанимации и интенсивной терапии ФГБУ «НМИЦ гематологии»
Russian Federation, MoscowIrina I. Kalinina
Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
Email: gengalst@gmail.com
ORCID iD: 0000-0002-0813-5626
канд. мед. наук, врач-гематолог отд-ния детской гематологии/онкологии ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева»
Russian Federation, MoscowReferences
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