Role of the intestinal MALT in pathogenesis of the IgA-nephropathy

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Abstract

Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or abnormal intestinal permeability are discussed in details. Based on supposed entero-renal pathogenesis of the disease future treatment modalities are considered. Relevant world’s literature is cited.

About the authors

Sergei V. Guliaev

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: guldoc@mail.ru
ORCID iD: 0000-0001-6138-4333

канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

Leonid A. Strizhakov

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: guldoc@mail.ru
ORCID iD: 0000-0002-2291-6453

д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), проф. каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова»

Russian Federation, Moscow; Moscow

Natalia V. Chebotareva

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: guldoc@mail.ru
ORCID iD: 0000-0003-2128-8560

д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), доц. каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова»

Russian Federation, Moscow; Moscow

Sergei V. Moiseev

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: guldoc@mail.ru
ORCID iD: 0000-0002-7232-4640

д-р мед. наук, зав. каф. внутренних, профессиональных болезней и ревматологии, дир. клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), проф. каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова»

Russian Federation, Moscow; Moscow

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