Email this article The state of cytokine regulation and endothelial dysfunction in the combined course of vibration disease and arterial hypertension
- Authors: Babanov S.A.1, Baraeva R.A.2, Strizhakov L.A.3, Moiseev S.V.3, Fomin V.V.3
-
Affiliations:
- Samara State Medical University
- Samara Medical and Sanitary Unit №5 of the Kirovsky District
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 93, No 6 (2021)
- Pages: 693-698
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/75961
- DOI: https://doi.org/10.26442/00403660.2021.06.200880
- ID: 75961
Cite item
Full Text
Abstract
Background. The article presents data on the state of cytokine regulation, indicators of endothelial damage when exposed to industrial vibration (general, local) and in combination with arterial hypertension.
Aim. To improve the quality of early diagnosis and prevention of vibration disease in an isolated course and its combination with arterial hypertension based on a study of the cytokine profile, biomarkers of endothelial dysfunction in this pathology.
Materials and methods. A comprehensive survey of 84 patients with isolated vibration disease from the effects of local, general, first, second degree and 61 patients with a combined course of vibration disease from the effects of local, general second degree vibration and arterial hypertension, 30 people in the control group without contact with industrial vibration and found healthy by medical examination. The levels of pro-inflammatory (IL-1β, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4), biomarkers of endothelial damage (EDN-1, TGF-β1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor) were determined using the enzyme immunoassay method.
Results. The response of the immune system to the effects of industrial vibration is characterized by a cytokine imbalance – an increase in the level of pro-inflammatory cytokines (IL-1β, IL-8, TNF-α) and a decrease in the level of anti-inflammatory cytokine (IL-4). With a combined course of vibratory disease and arterial hypertension, the cytokine imbalance is characterized by an even more significant increase in serum IL-1β, IL-8, TNF-α and a decrease in serum IL-4 concentration. Endothelial dysfunction with WB from the action of both local and general vibration in combination with hypertension is characterized by a significant increase in serum EDN-1, TGF-β1, VEGF-A, PDGF-BB, fibronectin, Willebrand factor.
Conclusion. The study of the cytokine profile, biomarkers of damage to the vascular endothelium in this pathology will allow for the early diagnosis of vascular disorders and to optimize preventive measures for workers in vibration-hazardous industries.
Full Text
##article.viewOnOriginalSite##About the authors
Sergei A. Babanov
Samara State Medical University
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-1667-737X
д-р мед. наук, проф., зав. каф. профессиональных болезней и клинической фармакологии им. засл. деят. науки РФ проф. В.В. Косарева ФГБОУ ВО СамГМУ
Russian Federation, SamaraRimma A. Baraeva
Samara Medical and Sanitary Unit №5 of the Kirovsky District
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-4502-4140
канд. мед. наук, зав. дневным стационаром ГБУЗ СО СМСЧ №5
Russian Federation, SamaraLeonid A. Strizhakov
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-2291-6453
д-р мед. наук, рук. Центра профессиональной патологии, проф. каф. внутренних, профес- сиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, MoscowSergei V. Moiseev
Sechenov First Moscow State Medical University (Sechenov University)
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-7232-4640
д-р мед. наук, проф., зав. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, MoscowViktor V. Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: strizhakov76@mail.ru
ORCID iD: 0000-0002-2682-4417
чл.-кор. РАН, д-р мед. наук, проф., проректор по клинической работе и дополнительному профессиональному образованию, зав. каф. факультетской терапии №1, дир. Клиники факультетской терапии им. В.Н. Виноградова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)
Russian Federation, MoscowReferences
- Измеров Н.Ф., Сквирская Г.П. Условия труда как фактор риска развития заболеваний и преждевременной смерти от сердечно-сосудистой патологии. Профилактика заболеваний и укрепление здоровья. 2003;5:11-5 [Izmerov NF, Skvirskaya GP. Working conditions as a risk factor for the development of diseases and premature death from cardiovascular pathology. Disease prevention and health promotion. 2003;5:11-5 (in Russian)].
- Профессиональные болезни. Под ред. Н.А. Мухина, С.А. Бабанова. М.: ГЭОТАР-Медиа, 2018 [Occupational diseases. Ed. NA Mukhin, SA Babanov. Moscow: GEOTAR-Media, 2018 (in Russian)].
- Bovenzi M. Vibration induced white finger and cold response of digital arterial vessels in occupational groups with various patterns of exposure to hand transmitted vibration. Scand J Work Environ Health. 1998;24(2):138-44
- Бодиенкова Г.М., Иванская Т.И., Лизарев А.В. Иммунопатогенез ВБ. Бюл. Восточно-сибирского научного центра Сибирского отделения РАМН. 2006;49(3):72-7 [Bodyenkova GM, Ivanskaya TI, Lizarev AV. Immunopathogenesis of WB. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. 2006;49(3):72-7 (in Russian)].
- Потеряева Е.Л. Роль нарушений сосудисто-тромбоцитарного гемостаза в патогенезе вибрационных микроангиопатий. Бюл. Сибирского отделения РАМН. 2004;4(114):52-3 [Poteryaeva EL. The role of disorders of vascular-platelet hemostasis in the pathogenesis of vibration microangiopathies. Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences. 2004;4(114):52-3 (in Russian)]
- Бабанов С.А., Азовскова Т.А., Вакурова Н.В., Бараева Р.А. Вибрационная болезнь. Оптимизация диагностических и лечебных мероприятий. М.: Вузовский учебник. Инфра-М, 2016 [Babanov SA, Azovskova TA, Vakurova NV, Baraeva RA. Vibration disease. Optimization of diagnostic and therapeutic measures. Moscow: University textbook. Infra-M, 2016 (in Russian)].
- Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ Statistica. М.: Медиасфера, 2003 [Rebrova OYu. Statistical analysis of medical data. Application of the Statistica software package. Moscow: Mediasfera, 2003 (in Russian)].
