电邮这篇文章 Vitamin D status in women with rheumatoid arthritis: frequency of hypovitaminosis, associations with disease activity, body composition and comorbidity
- 作者: Dobrovolskaya O.V.1, Toroptsova N.V.1, Nikitinskaya O.A.1, Samarkina E.Y.1, Cherkasova M.V.1, Feklistov A.Y.1
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隶属关系:
- Nasonova Research Institute of Rheumatology
- 期: 卷 93, 编号 5 (2021)
- 页面: 581-586
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/71512
- DOI: https://doi.org/10.26442/00403660.2021.05.200790
- ID: 71512
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Aim. To evaluate the status of vitamin D in women with rheumatoid arthritis (RA) and establish its associations with comorbidity, disease activity, and body composition components.
Materials and methods. 86 women with RA (average age 58.1±8.5 years) were enrolled in the study. We analyzed the relationship of vitamin D levels with clinical and laboratory parameters and with the results of two-energy x-ray absorptiometry. Mann–Whitney or Kruskal–Wallis, χ2 and Spearman tests were performed using Statistica for Windows 10.0 (StatSoft Inc., USA).
Results. Vitamin D level was 22.4 [17.8; 27.3] ng/ml: deficiency was detected in 33%, and insufficiency – in 46% of women with RA. Only 41% of patients with low vitamin D levels received supplements of cholecalciferol, while only 9% – in a sufficient dose. 25(OH)D level was significantly lower in RA patients with sarcopenia, obesity, high activity according to DAS28 and in those who did not receive vitamin D supplements. There weren’t differences in 25(OH)D levels among subgroups of patient according to age, fertility, BMD status, comorbidity index, RA duration, ESR and CRP levels, medical therapy performed.
Conclusion. 79% of patients with RA had low levels of vitamin D, while less than half of them received additional cholecalciferol supplements. Low vitamin D levels in RA patients were associated with high disease activity, sarcopenia, and obesity.
作者简介
Olga Dobrovolskaya
Nasonova Research Institute of Rheumatology
编辑信件的主要联系方式.
Email: olgavdobr@mail.ru
ORCID iD: 0000-0002-2809-0197
канд. мед. наук, науч. сотр. лаб. остеопороза
俄罗斯联邦, MoscowNatalia Toroptsova
Nasonova Research Institute of Rheumatology
Email: torop@irramn.ru
ORCID iD: 0000-0003-4739-4302
д-р мед. наук, зав. лаб. остеопороза
俄罗斯联邦, MoscowOksana Nikitinskaya
Nasonova Research Institute of Rheumatology
Email: nikitinskaya@niir.su
ORCID iD: 0000-0001-6759-8367
канд. мед. наук, ст. науч. сотр. лаб. остеопороза
俄罗斯联邦, MoscowElena Samarkina
Nasonova Research Institute of Rheumatology
Email: epid@irramn.ru
ORCID iD: 0000-0001-7501-9185
мл. науч. сотр. лаб. иммунологии и молекулярной биологии ревматических заболеваний
俄罗斯联邦, MoscowMariia Cherkasova
Nasonova Research Institute of Rheumatology
Email: epid@irramn.ru
ORCID iD: 0000-0002-3246-1157
канд. биол. наук, зав. лаб. иммунологии и молекулярной биологии ревматических заболеваний
俄罗斯联邦, MoscowAleksei Feklistov
Nasonova Research Institute of Rheumatology
Email: epid@irramn.ru
ORCID iD: 0000-0002-7661-3124
мл. науч. сотр. лаб. остеопороза
俄罗斯联邦, Moscow参考
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