The relationship between obesity, cardiometabolic disorders and disease activity in psoriatic arthritis patients: data from the Russian register

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Abstract

Aim. To study the relationship between obesity, cardiometabolic disorders and disease activity in patients with psoriatic arthritis (PsA) in real practice.

Materials and methods. The Russian register included 614 PsA patients [female – 331 (54%)/283 (46%)]. Average age – 45.2±0.52 years, PsA duration – 5.7±0.27 years, psoriasis – 15.71±0.56 years. Patients underwent examination, body mass index (BMI), PsA activity according to DAPSA, cDAPSA, analysis of concomitant diseases were assessed. The patients were divided into 3 groups depending on BMI (kg/m2): normal <25 (group 1), increased – 25–30 (group 2), obesity >30 (group 3).

Results. The average BMI was 27.7±0.23 kg/m2, normal BMI – in 213 (34.7%), increased – in 214 (34.8%) and obesity – in 187 (30.5%). Concomitant diseases – in 297 (48%). In group 3, arterial hypertension was observed significantly more often than in groups 1 and 2 (p<0.0001); more often than in group 2 – diabetes mellitus (p<0.0001), metabolic syndrome (p<0.0001); more often than in group 1 – ischemic heart disease (p=0.026). PsA activity at Baseline, after 6/12 months was significantly higher in group 3 (p<0.031). In obese patients, the chance of a decrease in disease activity to a moderate/low level and remission during therapy for 6/12 months is 2.484 times lower than in group 1, and 2.346 times lower than in group 2: odds ratio 2.346 (95% сonfidence interval 1.07–5.143) and 2.484 (95% сonfidence interval 1.135–5.439), respectively.

Conclusion. In the majority (65.3%) of PsA patients, BMI exceeded the norm. Obesity is associated with a high incidence of cardiometabolic disorders, with higher PsA activity and lower treatment efficacy.

About the authors

Yuliia L. Korsakova

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-5968-2403

канд. мед. наук, ст. науч. сотр. лаб. спондилоартритов и псориатического артрита

Russian Federation, Moscow

Tatiana V. Korotaeva

Nasonova Research Institute of Rheumatology

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0003-0579-1131

д-р мед. наук, зав. лаб. спондилоартритов и псориатического артрита

Russian Federation, Moscow

Elena I. Loginova

Nasonova Research Institute of Rheumatology

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-6875-4552

канд. мед. наук, ст. науч. сотр. лаб. спондилоартритов и псориатического артрита

Russian Federation, Moscow

Elena E. Gubar

Nasonova Research Institute of Rheumatology

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0001-5015-7143

канд. мед. наук, науч. сотр. лаб. спондилоартритов и псориатического артрита

Russian Federation, Moscow

Elizaveta A. Vasilenko

Mechnikov North-Western State Medical University

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0003-2153-5429

ассистент каф. терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда

Russian Federation, Saint Petersburg

Aleksei A. Vasilenko

Novgorod Regional Clinical Hospital

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0002-5486-2576

зав. ревматологическим отд. ГОБУЗ НОКБ

Russian Federation, Veliky Novgorod

Natalia A. Kuznetsova

City Clinical Hospital №40

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0002-4972-7716

канд. мед. наук, врач-ревматолог консультативно-диагностической поликлиники ГАУЗ СО «ГКБ №40»

Russian Federation, Ekaterinburg

Irina M. Patrikeeva

Regional Clinical Hospital №1

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0003-0530-0080

зав. ревматологическим отд. ГБУЗ ТО «ОКБ №1», гл. специалист-ревматолог Департамента здравоохранения Тюменской области

Russian Federation, Tyumen

Evgeny L. Nasonov

Nasonova Research Institute of Rheumatology; Sechenov First Moscow State Medical University (Sechenov University)

Email: yulkorsakova@bk.ru
ORCID iD: 0000-0002-1598-8360

акад. РАН, д-р мед. наук, проф., науч. рук. ФГБНУ «НИИ ревматологии им. В.А. Насоновой», проф. ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»

Russian Federation, Moscow; Moscow

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Supplementary files

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2. Fig. 1. Comparison of the probabilities of a decrease in PsA activity by the DAPSA index depending on BMI.

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3. Fig. 2. Dynamics of the DAPSA index during 6 and 12 months of therapy depending on BMI.

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