Impact of summer heat waves on key parameters of oxidative stress in patients with coronary artery disease

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Abstract

Aim. To assess the impact of summer heat waves on key parameters of oxidative stress in patients with coronary heart disease.

Materials and methods. We included 30 male patients aged 52±13 years with stable angina pectoris of II–III functional class with at least one coronary artery stenosis proved by angiography (ischemic group) in comparison with 10 male patients aged 48±7 years with no angiographic sings of significant coronary stenosis and without angina manifestation (non-ischemic group). The following parameters were studied: activity of superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), the level of malondialdehyde (MDA) and MDA-modified low-density lipoproteins (MDA-LDL). The analysis of indicators was performed at normal average daily temperature (daytime temperature not higher than 20°С) and after a heat wave (daytime temperature above 27°C for more than 2 consecutive days).

Results. Our study revealed the decrease of CAT and GSH-Px activities with increased activity of Cu,Zn-SOD in both groups after the heat wave. At the same time we observed accumulation of MDA and increased MDA-LDL level in both groups. Initially ischemic patients showed significantly increased level of CAT and GSH-Px activity compared to the non-ischemic group, while it was no difference in activity of Cu,Zn-SOD and MDA and MDA-LDL level. We observed significant reduce of Cu,Zn-SOD activity in ischemic patients compared to non-ischemic group with no significant differences in all other studied parameters of oxidative stress after heat wave.

Conclusion. Changes in the key parameters of oxidative stress in patients with ischemic heart disease during summer heat waves are comparable to those in patients without ischemia, however significantly greater inhibition of GSH-Px activity and significantly lower increase in Cu,Zn-SOD activity was noted. These results may indicate misregulation of free radical processes in patients with ischemic heart decease

About the authors

Mariia K. Osyaeva

National Medical Research Center of Cardiology

Author for correspondence.
Email: osyaeva.m@gmail.com
ORCID iD: 0000-0002-5208-6032

врач-кардиолог 2-го клинического отд-ния

Russian Federation, Moscow

Alla K. Tikhaze

National Medical Research Center of Cardiology

Email: osyaeva.m@gmail.com
ORCID iD: 0000-0003-3870-9923

д.м.н., проф., гл. науч. сотр. отд. биохимии свободнорадикальных процессов Института клинической кардиологии им. А.Л. Мясникова 

Russian Federation, Moscow

Galina G. Konovalova

National Medical Research Center of Cardiology

Email: osyaeva.m@gmail.com
ORCID iD: 0000-0002-0172-9472

к.б.н., ст. науч. сотр. отд. биохимии свободнорадикальных процессов Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

Grigorii I. Heimets

National Medical Research Center of Cardiology

Email: osyaeva.m@gmail.com
ORCID iD: 0000-0003-3672-1830

к.б.н., ст. науч. сотр. отд. новых методов диагностики Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

Tamila V. Martynyuk

National Medical Research Center of Cardiology; Pirogov Russian National Research Medical University

Email: osyaeva.m@gmail.com
ORCID iD: 0000-0002-9022-8097

д.м.н., рук. отд. легочной гипертензии и заболеваний сердца Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии», проф. каф. кардиологии ФДПО ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»

Russian Federation, Moscow

Vadim Z. Lankin

National Medical Research Center of Cardiology

Email: osyaeva.m@gmail.com
ORCID iD: 0000-0002-8018-0296

д.б.н., проф., гл. науч. сотр., рук. отд. биохимии свободнорадикальных процессов Института клинической кардиологии им. А.Л. Мясникова

Russian Federation, Moscow

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2. Fig. 1. Change in the activity of antioxidant enzymes (in%) in the erythrocytes of patients of the comparison group (light bars) and the group of patients with coronary artery disease (dark bars), measured during summer heat waves, compared with measurements made at a comfortable temperature; * p <0.05

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3. Fig. 2. Change in the parameters of oxidative stress (in%) in the blood plasma of patients of the comparison group (light bars) and the group of patients with coronary artery disease (dark bars), measured during summer heat waves, compared with measurements made at a comfortable temperature

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