Methotrexate-induced lung damage in a patient with rheumatoid arthritis

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Abstract

We herein report a case of interstitial lung disease secondary to the use of methotrexate in a patient with rheumatoid arthritis. Differential diagnosis between pneumonitis caused by methotrexate in patients treated with basic methotrexate therapy and interstitial pulmonary disease associated with rheumatoid arthritis is based on the clinical examination and instrumental data. The main condition for favorable clinical outcome in all drug-induced lung disease is drug withdrawal, what was proven in our report.

About the authors

Liubov A. Ponomareva

Sechenov First Moscow State Medical University (Sechenov University)

Email: ela12@yandex.ru
ORCID iD: 0000-0002-3179-470X

студентка Международной школы «Медицина будущего»

Russian Federation, Moscow

Daria V. Gurova

Sechenov First Moscow State Medical University (Sechenov University)

Email: ela12@yandex.ru
ORCID iD: 0000-0001-8232-3679

студентка Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

Elena N. Popova

Sechenov First Moscow State Medical University (Sechenov University)

Email: ela12@yandex.ru
ORCID iD: 0000-0001-5164-4621

д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

Natalia V. Chebotareva

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: ela12@yandex.ru

д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

Inna B. Bondarenko

Sechenov First Moscow State Medical University (Sechenov University)

Email: ela12@yandex.ru
ORCID iD: 0000-0002-4111-1175

к.м.н., ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

Sergey V. Moiseev

Sechenov First Moscow State Medical University (Sechenov University)

Email: ela12@yandex.ru
ORCID iD: 0000-0002-7232-4640

д.м.н., проф., зав. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского

Russian Federation, Moscow

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2. Changes in the lungs of a patient with RA when taking MT: a "ground glass" symptom, interstitial fibrosis in the basal regions

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