Evaluation of the effectiveness of Riamilovir in the complex therapy of patients with COVID-19
- Authors: Kasyanenko K.V.1, Kozlov K.V.1, Maltsev O.V.1, Lapikov I.I.2, Gordienko V.V.1, Sharabhanov V.V.1, Sorokin P.V.3, Zhdanov K.V.1
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Affiliations:
- Kirov Military Medical Academy
- Immanuel Kant Baltic Federal University
- LLC “Azol Farma”
- Issue: Vol 93, No 3 (2021)
- Pages: 290-294
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/64960
- DOI: https://doi.org/10.26442/00403660.2021.03.200719
- ID: 64960
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Abstract
Aim. In this study we evaluated the effects of Riamilovir on SARS-CoV-2 viral shedding and on admission duration in patients with moderate COVID-19.
Materials and methods. We have used data from 69 health records of patients with moderate severe PCR confirmed SARS-CoV-2 infection. Control group included 34 patients treated with off-label riamilovir 1250 mg per day for 5 days (250 mg 5 times a day), comparison groups – 35 patients, who received ribavirin and umifenovir 800 mg a day for 5 days. The antiviral therapy was administered within 72 hours from the onset of the disease. The primary endpoints were elimination of virus in oropharyngeal and nasopharyngeal swabs on 7 day of admission and discharge from the hospital by 14 day.
Results. Patients assigned to riamilovir had significantly shorter time to clinical improvement as well as increased PCR negative rate by day 7.
Conclusion. Yearly administration of riamilovir as opposed to the umifenovir and ribavirin in therapy of moderate SARS-CoV-2 infection was associated with significant shorter time to clinical improvement by 14 day of hospitalization. PCR negative rate by 7 days of hospitalization is significantly more likely in riamilovir group.
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##article.viewOnOriginalSite##About the authors
Kristina V. Kasyanenko
Kirov Military Medical Academy
Author for correspondence.
Email: dr.snegur@gmail.com
ORCID iD: 0000-0001-9294-7346
преподаватель каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, St. PetersburgKonstantin V. Kozlov
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-4398-7525
д.м.н., доц., доц. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, St. PetersburgOleg V. Maltsev
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-6286-9946
к.м.н., ст. преподаватель каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, St. PetersburgIgor I. Lapikov
Immanuel Kant Baltic Federal University
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-2185-3198
к.т.н., доц. Института физико-математических наук и информационных технологий ФГАОУ ВО «БФУ им. И. Канта»
Russian Federation, KaliningradVera V. Gordienko
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0003-2078-2196
преподаватель каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, St. PetersburgValerian V. Sharabhanov
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-0526-6006
адъюнкт ФГБВОУ ВО «ВМА им. С.М. Кирова» при каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний)
Russian Federation, St. PetersburgPavel V. Sorokin
LLC “Azol Farma”
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-1477-8521
к.фарм.н., ген. дир. ООО «Азол фарма»
Russian Federation, NovouralskKonstantin V. Zhdanov
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
чл.-кор. РАН, д.м.н., проф., нач. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, St. PetersburgReferences
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