Prevalence of small bowel bacterial overgrowth in patients with functional dyspepsia: a meta-analysis

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Abstract

Aim. Systematization of data on the frequency of detection of the syndrome of bacterial overgrowth in the small intestine (SIBO) in patients with functional dyspepsia (FD).

Materials and methods. MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, the Russian Science Citation Index (RSCI) through July 2020 were searched to identify studies evaluating the prevalence of SIBO in FD. In addition, a search for relevant abstracts was carried out in the electronic databases of the United European Gastroenterology Week (UEG), American College of Gastroenterology (ACG), International Conference on Nutrition and Food (ICNF). For the final analysis, publications were selected that used validated tests for the assessment of SIBO (hydrogen breath test using glucose or lactulose) with detailed descriptive statistics, allowing the resulting data to be included in the meta-analysis.

Results. The final analysis included 7 studies with 1248 patients with FD. Overall pooled prevalence of SIBO in patients with FD was 34.73% (95% CI 24.807–45.383). There was significant heterogeneity between the results (p<0.0001; I2=89.91%). When excluded from the meta-analysis of a study in which the incidence of SIBO was studied in patients with refractory FD, the pooled prevalence was 38.98% (95% CI 28.964–49.490).

Conclusion. This meta-analysis has demonstrated that SIBO is often associated with FD and is observed in about every third patient with this functional gastrointestinal tract disease.

About the authors

Yu. A. Kucheryavyy

Yevdokimov Moscow State University of Medicine and Dentistry

Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-7760-2091

к.м.н., доц. каф.

Russian Federation, Moscow

D. N. Andreev

Yevdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: dna-mit8@mail.ru
ORCID iD: 0000-0002-4007-7112

к.м.н., доц. каф.

Russian Federation, Moscow

I. V. Maev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: dna-mit8@mail.ru
ORCID iD: 0000-0001-6114-564X

акад. РАН, д.м.н, проф., зав. каф., засл. врач РФ, засл. деятель науки РФ

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Figure: 1. CONSORT diagram detailing the study selection strategy.

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3. Figure: 2. Forest diagram showing the generalized incidence of SIBO in patients with PD.

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4. Figure: 3. Funnel scatterplot to assess the likelihood of publication bias.

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