Factors associated with a reduction in glomerular filtration rate in patients with chronic obstructive pulmonary disease

Aim. Analysis of factors associated with reduced glomerular filtration rate (GFR) in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The study included 198 patients with COPD 1-4 degrees of severity (GOLD 2014), who were on examination and treatment in Krasnodar Regional clinical hospital № 2. The control group consisted of 28 healthy volunteers, comparable in age and sex. In addition to clinical research, all patients, we calculated GFR according to the formula CKD-EPI based on cystatin C serum (GFRcys). The contribution of the factors in the risk of developing CKD was determined using multivariate linear regression analysis, as dependent variable used the value of GFRcys. Results and discussion. It was found that more than half (51.5%) of patients with COPD have a decrease in GFRcys <60 ml/min/1.73 m2, which is the basis for the diagnosis of CKD without laboratory and instrumental studies. During the regression analysis with direct step - by - step inclusion of the selected variables, the independent factors associated with a decrease in GFR in COPD patients were determined: the value of FEV1, SpO2, the number of points on the mMRC scale, the level of C-reactive protein, fibrinogen, and the smoker index. The high incidence of CKD in patients with COPD (51.5%), as well as the correlation between the presence of renal dysfunction and the severity of COPD were revealed. The influence of clinical and diagnostic parameters of COPD severity on the development of renal dysfunction was confirmed.

glomerular filtration rate, chronic obstructive pulmonary disease, chronic kidney disease, comorbidity, systemic effects of chronic obstructive pulmonary disease, glomerular filtration rate, chronic obstructive pulmonary disease, chronic kidney disease, comorbidity, systemic effects of chronic obstructive pulmonary disease