Visceral leishmaniasis: a challenging diagnosis in internal medicine


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Abstract

Leishmaniasis is a vector-born parasitic disease characterized by predominant cutaneous or visceral involvement with fever, hepatosplenomegaly and anemia. Leishmaniasis has relatively high prevalence in tropical and subtropical areas. Several sporadic and mostly imported cases are detected in Russian Federation. Nevertheless, some local incidents are noted in southern areas (Crimea, Dagestan). Lack of epidemiological alertness hampers confirmation of diagnosis and may lead to incorrect treatment. The article summarizes current state of knowledge in epidemiology, diagnostic approach and treatment of leishmaniasis. Particular clinical case is discussed.

 

About the authors

M. Iu. Brovko

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru
ORCID iD: 0000-0003-0023-2701

к.м.н., зав. отд-нием профпатологии и пульмонологии, Клиника им. Е.М. Тареева, Университетская клиническая больница №3

Russian Federation, Moscow

L. A. Akulkina

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru
ORCID iD: 0000-0002-4307-8882

врач отд-ния профпатологии и пульмонологии, Клиника им. Е.М. Тареева, Университетская клиническая больница №3

Russian Federation, Moscow

P. P. Potapov

Lomonosov Moscow State University

Email: vsholomova@mail.ru
ORCID iD: 0000-0003-4366-2832

клинический ординатор каф. внутренних болезней фак-та фундаментальной медицины

Russian Federation, Moscow

V. I. Sholomova

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-8785-7968

врач-пульмонолог отд-ния профпатологии и пульмонологии Клиники им. Е.М. Тареева, Университетская клиническая больница №3, ассистент каф. внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

M. V. Lebedeva

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru

к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

T. P. Nekrasova

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru
ORCID iD: 0000-0001-6376-9392

к.м.н., доц. каф. патологической анатомии им. А.И. Струкова

Russian Federation, Moscow

V. A. Varshavskii

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru

д.м.н., проф. каф. патологической анатомии им. А.И. Струкова

Russian Federation, Moscow

E. V. Volchkova

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru

д.м.н., проф., зав. каф. инфекционных болезней

Russian Federation, Moscow

T. P. Rozina

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: vsholomova@mail.ru
ORCID iD: 0000-0002-7939-1416

к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии; доц. каф. внутренних болезней фак-та фундаментальной медицины 

Russian Federation, Moscow

E. N. Nikulkina

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru
ORCID iD: 0000-0001-6084-8749

ассистент каф. внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

L. S. Karan

Central Research Institute of Epidemiology

Email: vsholomova@mail.ru
ORCID iD: 0000-0002-5927-460X

науч. сотр.

Russian Federation, Moscow

S. V. Moiseev

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: vsholomova@mail.ru
ORCID iD: 0000-0002-7232-4640

д.м.н., проф., дир. Клиники им. Е.М. Тареева, зав. каф. внутренних, профессиональных болезней и ревматологии

Russian Federation, Moscow

V. V. Fomin

Sechenov First Moscow State Medical University (Sechenov University)

Email: vsholomova@mail.ru
ORCID iD: 0000-0002-2682-4417

чл.-кор. РАН, д.м.н., проф., зав. каф. факультетской терапии №1

Russian Federation, Moscow

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2. Figure: 1. Focuses of coagulation necrosis in the parenchyma and stroma of the liver without pronounced inflammatory infiltration, with signs of karyorrhexis. Large-drop fatty degeneration of individual hepatocytes. Hematoxylin-eosin staining, * 100

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3. Figure: 2. a - Single macrophage granulomas are located in the bone marrow trepanobiopsy. Hematoxylin-eosin staining, * 200

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4. Figure: 2. b - In the bone marrow trepanobiopsy, small foci of necrosis with weak inflammatory infiltration, signs of karyorrhexis are determined. Hematoxylin-eosin staining, * 200

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