Visceral leishmaniasis: a challenging diagnosis in internal medicine
- Authors: Brovko M.I.1, Akulkina L.A.1, Potapov P.P.2, Sholomova V.I.1, Lebedeva M.V.1, Nekrasova T.P.1, Varshavskii V.A.1, Volchkova E.V.1, Rozina T.P.1,2, Nikulkina E.N.1, Karan L.S.3, Moiseev S.V.1,2, Fomin V.V.1
-
Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Lomonosov Moscow State University
- Central Research Institute of Epidemiology
- Issue: Vol 92, No 11 (2020)
- Pages: 117-121
- Section: Lecture
- URL: https://journals.rcsi.science/0040-3660/article/view/56949
- DOI: https://doi.org/10.26442/00403660.2020.11.000619
- ID: 56949
Cite item
Full Text
Abstract
Leishmaniasis is a vector-born parasitic disease characterized by predominant cutaneous or visceral involvement with fever, hepatosplenomegaly and anemia. Leishmaniasis has relatively high prevalence in tropical and subtropical areas. Several sporadic and mostly imported cases are detected in Russian Federation. Nevertheless, some local incidents are noted in southern areas (Crimea, Dagestan). Lack of epidemiological alertness hampers confirmation of diagnosis and may lead to incorrect treatment. The article summarizes current state of knowledge in epidemiology, diagnostic approach and treatment of leishmaniasis. Particular clinical case is discussed.
Full Text
##article.viewOnOriginalSite##About the authors
M. Iu. Brovko
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
ORCID iD: 0000-0003-0023-2701
к.м.н., зав. отд-нием профпатологии и пульмонологии, Клиника им. Е.М. Тареева, Университетская клиническая больница №3
Russian Federation, MoscowL. A. Akulkina
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-4307-8882
врач отд-ния профпатологии и пульмонологии, Клиника им. Е.М. Тареева, Университетская клиническая больница №3
Russian Federation, MoscowP. P. Potapov
Lomonosov Moscow State University
Email: vsholomova@mail.ru
ORCID iD: 0000-0003-4366-2832
клинический ординатор каф. внутренних болезней фак-та фундаментальной медицины
Russian Federation, MoscowV. I. Sholomova
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-8785-7968
врач-пульмонолог отд-ния профпатологии и пульмонологии Клиники им. Е.М. Тареева, Университетская клиническая больница №3, ассистент каф. внутренних, профессиональных болезней и ревматологии
Russian Federation, MoscowM. V. Lebedeva
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии
Russian Federation, MoscowT. P. Nekrasova
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
ORCID iD: 0000-0001-6376-9392
к.м.н., доц. каф. патологической анатомии им. А.И. Струкова
Russian Federation, MoscowV. A. Varshavskii
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
д.м.н., проф. каф. патологической анатомии им. А.И. Струкова
Russian Federation, MoscowE. V. Volchkova
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
д.м.н., проф., зав. каф. инфекционных болезней
Russian Federation, MoscowT. P. Rozina
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-7939-1416
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии; доц. каф. внутренних болезней фак-та фундаментальной медицины
Russian Federation, MoscowE. N. Nikulkina
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
ORCID iD: 0000-0001-6084-8749
ассистент каф. внутренних, профессиональных болезней и ревматологии
Russian Federation, MoscowL. S. Karan
Central Research Institute of Epidemiology
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-5927-460X
науч. сотр.
Russian Federation, MoscowS. V. Moiseev
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-7232-4640
д.м.н., проф., дир. Клиники им. Е.М. Тареева, зав. каф. внутренних, профессиональных болезней и ревматологии
Russian Federation, MoscowV. V. Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: vsholomova@mail.ru
ORCID iD: 0000-0002-2682-4417
чл.-кор. РАН, д.м.н., проф., зав. каф. факультетской терапии №1
Russian Federation, MoscowReferences
- World Health Organization, Working to overcome the global impact of neglected tropical diseases: First WHO Report on neglected tropical diseases (Geneva: World Health Organization 2010). Accessed 7 Oct 2018.
- Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, et al. Leishmaniasis: a review. F1000 Res. 2017;6:750.
- WHO. Epidemiological situation. WHO – 2018.
- Баранец М.С., Ермак Т.Н., Понировский Е.Н. Клинико-эпидемиологические особенности висцерального лейшманиоза в Республике Крым. Терапевтический архив. 2017;89(11):100-4 [Baranets MS, Ermak TN, Ponirovsky EN. Clinical and epidemiological features of visceral leishmaniasis in the Republic of Crimea. Therapeutic Archive. 2017;89(11):100-4 (In Russ.)]. doi: 10.17116/terarkh20178911100-104
- Aronson N, Herwaldt BL, Libman M, et al. Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Am J Trop Med Hyg. 2017;96(1):24-5. doi: 10.4269/ajtmh.16-84256
- Srivastava P, Dayama A, Mehrotra S, et al. Diagnosis of visceral leishmaniasis. Trans R Soc Trop Med Hyg. 2011;105(1):1-6. doi: 10.1016/j.trstmh.2010.09.006
- Antinori S, Calattini S, Longhi E, et al. Clinical Use of Polymerase Chain Reaction Performed on Peripheral Blood and Bone Marrow Samples for the Diagnosis and Monitoring of Visceral Leishmaniasis in HIV-Infected and HIV-Uninfected Patients: A Single-Center, 8-Year Experience in Italy and Review of the Literature. Clin Infect Dis. 2007;44(12):1602-10. doi: 10.1086/518167
- Boelaert M, Verdonck K, Menten J. Rapid tests for the diagnosis of visceral leishmaniasis in patients with suspected disease. Cochrane Database Syst Rev. 2014. doi: 10.1002/14651858.CD009135.pub2
- Hickey AJ, Gounder L, Moosa M-YS, et al. A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection. BMC Infect Dis. 2015;15:209. doi: 10.1186/s12879-015-0944-6
- Dean AS, Crump L, Greter H, et al. Clinical Manifestations of Human Brucellosis: A Systematic Review and Meta-Analysis. PLoS Negl Trop Dis. 2012;6(12):e1929с. doi: 10.1371/journal.pntd.0001929
- Shaker Y, Samy N, Ashour E. Hepatobiliary Schistosomiasis. J Clin Transl Hepatol. 2014;2(3):212-6. doi: 10.14218/JCTH.2014.00018
- Kawakami A, Fukunaga T, Usui M. Visceral leishmaniasis misdiagnosed as malignant lymphoma. Intern Med. 1996;35(6):502-6. doi: 10.2169/internalmedicine.35.502
- Yabe M, Miranda RN, Medeiros LJ. Hepatosplenic T-cell Lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. Hum Pathol. 2018;74(5):16. doi: 10.1016/j.humpath.2018.01.005
- Lunning MA, Vose JM. Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma. Blood. 2017;129(9):1095-102. doi: 10.1182/blood-2016-09-692541
- Lamy T, Moignet A, Loughran TP. LGL leukemia: from pathogenesis to treatment. Blood. 2017;129(9):1082-94. doi: 10.1182/blood-2016-08-692590
- Owlia MB, Newman K, Akhtari M. Felty’s Syndrome, Insights and Updates. Open Rheumatol J. 2014;8(129):36. doi: 10.2174/1874312901408010129
- Liberopoulos E, Kei A, Apostolou F, et al. Autoimmune manifestations in patients with visceral leishmaniasis. J Microbiol Immunol Infect. 2013;46(4):302-5. doi: 10.1016/j.jmii.2012.01.016
- Santana IU, Dias B, Nunes EAS. Visceral leishmaniasis mimicking systemic lupus erythematosus: Case series and a systematic literature review. Semin. Arthritis Rheum. 2015;44(6):658-65. doi: 10.1016/j.semarthrit.2014.12.004
Supplementary files
![](/img/style/loading.gif)